Jennifer A. Chan
A5067228740- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Chromatin Remodeling and Cancer
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Hedgehog Signaling Pathway Studies
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Colorectal Cancer Treatments and Studies
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Gastric Cancer Management and Outcomes
- Developmental Biology and Gene Regulation
- Neurofibromatosis and Schwannoma Cases
- Cancer Mechanisms and Therapy
- Meningioma and schwannoma management
- RNA Research and Splicing
- Childhood Cancer Survivors' Quality of Life
Dana-Farber Cancer Institute
2015-2025
Harvard University
2012-2025
Simon Fraser University
2023-2025
Canada's Michael Smith Genome Sciences Centre
2023-2025
University of Calgary
2015-2024
Alberta Children's Hospital
2014-2024
Northwestern University
2024
Mayo Clinic
2010-2024
Boston Medical Center
2024
Cancer Institute (WIA)
2018-2024
Abstract MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression by targeting the mRNA of protein-coding genes for either cleavage or repression translation. The roles miRNAs in lineage determination and proliferation as well location several miRNA at sites translocation breakpoints deletions has led to speculation could be important factors development maintenance neoplastic state. Here we show highly malignant human brain tumor, glioblastoma, strongly...
It is a challenge to identify patients who, after undergoing potentially curative treatment for hepatocellular carcinoma, are at greatest risk recurrence. Such high-risk could receive novel interventional measures. An obstacle the development of genome-based predictors outcome in with carcinoma has been lack means carry out genomewide expression profiling fixed, as opposed frozen, tissue.We aimed demonstrate feasibility gene-expression more than 6000 human genes formalin-fixed,...
Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded divergent results, indicating difficulty in identifying unified molecular anatomy. We performed meta-analysis of gene expression profiles data sets from eight independent patient cohorts across the world. In addition, aiming establish real world applicability system, we profiled 118 formalin-fixed, paraffin-embedded tissues an additional cohort. A...
Physically active individuals have a lower risk of developing colorectal cancer but the influence exercise on survival is unknown.By prospective, observational study 573 women with stage I to III cancer, we studied cancer-specific and overall mortality according predefined physical activity categories before after diagnosis by change in diagnosis. To minimize bias occult recurrences, excluded who died within 6 months their postdiagnosis assessment.Increasing levels nonmetastatic reduced (P...
The vast majority of brain tumors in adults exhibit glial characteristics. Brain children are diverse: Many have neuronal characteristics, whereas others features. Here we show that activation the G i protein-coupled receptor CXCR4 is critical for growth both malignant and tumors. Systemic administration antagonist AMD 3100 inhibits intracranial glioblastoma medulloblastoma xenografts by increasing apoptosis decreasing proliferation tumor cells. This reflects ability to reduce extracellular...
Detection of critical cancer gene mutations in clinical tumor specimens may predict patient outcomes and inform treatment options; however, high-throughput mutation profiling remains underdeveloped as a diagnostic approach. We report the implementation genotyping validation algorithm that enables robust setting.We developed implemented an optimized platform ("OncoMap") to interrogate approximately 400 33 known oncogenes suppressors, many which are response or resistance targeted therapies....
Abstract Author Summary Background. Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, patients with analyzed pharmacodynamic markers treated mice. Methods. Patients previously metastatic were administered HCQ at 400 mg (n = 10) or 600 twice daily. The primary endpoint was 2-month progression-free survival (PFS)....
Activation of the transcription factor STAT3 is thought to potently promote oncogenesis in a variety tissues, leading intense efforts develop inhibitors for many tumors, including highly malignant brain tumor glioblastoma. However, function glioblastoma pathogenesis has remained unknown. Here, we report that plays pro-oncogenic or tumor-suppressive role depending on mutational profile tumor. Deficiency suppressor PTEN triggers cascade inhibits signaling murine astrocytes and human tumors....
Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma genes have not been defined and screening guidelines for genetic counselling testing paediatric patients are available. We aimed to assess define these provide evidence future guidelines.
The PI3K/Akt/mTOR pathway is activated in the majority of pancreatic cancers, and inhibition this has antitumor effects preclinical studies. We performed a multi-institutional, single-arm, phase II study RAD001(everolimus), an oral inhibitor mTOR, patients who experienced treatment failure on first-line therapy with gemcitabine.Thirty-three gemcitabine-refractory, metastatic cancer were treated continuously RAD001 at 10 mg daily. Prior fluorouracil perioperative setting was allowed. Patients...
Oligodendroglioma is characterized by unique clinical, pathological, and genetic features. Recurrent losses of chromosomes 1p 19q are strongly associated with this brain cancer but knowledge the identity function genes affected these alterations limited. We performed exome sequencing on a discovery set 16 oligodendrogliomas 1p/19q co-deletion to identify new molecular features at base-pair resolution. As anticipated, there was high rate IDH mutations: all cases had mutations in either IDH1...
Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, histologic variant. Stark prognostic genetic differences among the subgroups suggest that subgroup-specific biomarkers could improve prognostication.Molecular were identified from a discovery set 673 medulloblastomas 43 cities around world. Combined risk stratification models...
To uncover the genetic events leading to transformation of pediatric low-grade glioma (PLGG) secondary high-grade (sHGG).We retrospectively identified patients with sHGG from a population-based cohort 886 PLGG long clinical follow-up. Exome sequencing and array CGH were performed on available samples followed by detailed analysis entire cohort. Clinical outcome data genetically distinct subgroups obtained.sHGG was observed in 2.9% PLGGs (26 patients). Patients had high frequency nonsilent...
Abstract Purpose: Oncogenic fusions consisting of fibroblast growth factor receptor (FGFR) and TACC are present in a subgroup glioblastoma (GBM) other human cancers have been proposed as new therapeutic targets. We analyzed frequency molecular features FGFR–TACC explored the efficacy inhibiting FGFR kinase GBM grade II III glioma. Experimental Design: Overall, 795 gliomas (584 GBM, 85 grades with wild-type 126 IDH1/2 mutation) were screened for breakpoints associated profile. also expression...
The combination of ataxia and hypogonadism was first described more than a century ago, but its genetic basis has remained elusive.We performed whole-exome sequencing in patient with hypogonadotropic hypogonadism, followed by targeted candidate genes similarly affected patients. Neurologic reproductive endocrine phenotypes were characterized detail. effects sequence variants the presence an epistatic interaction tested zebrafish model.Digenic homozygous mutations RNF216 OTUD4, which encode...
Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but, apart from BRAF kinase mutations or duplications specific subclasses, few genetic driver events known. Diffuse PLGGs comprise a set of uncommon subtypes that exhibit invasive growth and therefore especially challenging clinically. We performed high-resolution copy-number analysis on 44 formalin-fixed, paraffin-embedded diffuse to identify recurrent alterations. exhibited fewer such alterations than...