A5113644776- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Childhood Cancer Survivors' Quality of Life
- Ocular Oncology and Treatments
- Histiocytic Disorders and Treatments
- Renal and related cancers
- Tumors and Oncological Cases
- Acute Lymphoblastic Leukemia research
- Circular RNAs in diseases
- Testicular diseases and treatments
- MicroRNA in disease regulation
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cancer-related molecular mechanisms research
- Parvovirus B19 Infection Studies
- Renal cell carcinoma treatment
- Extracellular vesicles in disease
- Advanced Neural Network Applications
- Adrenal and Paraganglionic Tumors
- Chromatin Remodeling and Cancer
- Antifungal resistance and susceptibility
- Pituitary Gland Disorders and Treatments
Jordan University of Science and Technology
2025
Cairo University
2015-2024
Children Cancer Hospital
2015-2024
National Research Centre
2023
Weatherford College
2023
Charité - Universitätsmedizin Berlin
2018
Zayed Military Hospital
2015-2017
Cancer Institute (WIA)
2017
Al-Azhar University
2017
University of Khartoum
2015
Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but, apart from BRAF kinase mutations or duplications specific subclasses, few genetic driver events known. Diffuse PLGGs comprise a set of uncommon subtypes that exhibit invasive growth and therefore especially challenging clinically. We performed high-resolution copy-number analysis on 44 formalin-fixed, paraffin-embedded diffuse to identify recurrent alterations. exhibited fewer such alterations than...
ABSTRACT Introduction Prevalence estimates and correlates of ARFID in non‐Western samples are lacking. This study aims to estimate the prevalence symptoms, identify its phenotypes, explore a community sample from Gulf Cooperation Council (GCC). Method Participants were parents children aged 4–13 years ( n = 87) individuals ≥ 14 old 433). They completed Pica, ARFID, Rumination Disorder Interview‐ARFID‐Questionnaire (PARDI‐AR‐Q), Nine Item Screen (NIAS) Eating Examination‐Questionnaire...
The purpose of this study was to determine the prevalence HSPM, its clinical presentation and any association MIH in Jordanian children. HSPM were quite prevalent schoolchildren. two conditions significantly associated with each other, but not predictive MIH.
<div>AbstractBackground:<p>Central nervous system (CNS) tumors are the leading cause of cancer-related deaths in children. Although most cases come from low- and middle-income countries (LMIC) where their prognosis is worse, few epidemiologic studies conducted these regions.</p>Methods:<p>We a registry-based cohort study for childhood CNS at Children’s Cancer Hospital, Egypt, over 15 years. Unified treatment protocols were implemented. Survival analyses using...
<p>Detailed pathological diagnosis for all childhood CNS tumors included in the cohort. Bars represent count of each subtype. Pilocytic astrocytoma was most common subtype.</p>
Understanding pediatric brain tumor biology is essential to help on disease stratification, and find novel markers for early diagnosis. MicroRNA (miRNA) expression has been linked clinical outcomes biology. Here, we aimed detect the of different miRNAs in subtypes discover biomarkers detection develop therapies. Expression 82 was detected 120 tumors from fixed-formalin paraffin-embedded tissues, low-grade glioma, high-grade ependymoma, medulloblastoma, using quantitative real-time PCR....
Abstract: Mycetoma is a chronic infectious disease of the subcutaneous tissue with high morbidity. This most commonly seen in countries between 30°N and 15°S equator, but cases have also been Europe USA. Due to lack proper prevalence data, currently true burden this not known. can be caused by large variety microorganisms, both bacteria fungi. Treatment depends on etiology causative agent. Actinomycetoma usually treated antibiotics only has decent cure rate; eumycetoma combination surgery....
Atypical teratoid rhabdoid tumor (ATRT) is a rare type of potentially fatal childhood brain tumor. The present study aimed to examine the overall survival (OS) and event-free (EFS) outcomes pediatric patients with ATRT analyze impact different prognostic factors, including age, sex, site size, metastatic disease, extent resection, radiotherapy, chemotherapy, on survival. included 47 treated at Children's Cancer Hospital Egypt (Cairo, Egypt) between July 2007 December 2017. These were...
Mucormycosis represents a real challenge in immunocompromised patients. This study aimed to describe the clinical characteristics, treatment outcome and infection-related mortality our patients at Children's Cancer Hospital 57357, Cairo, Egypt. is retrospective during period 2007-2017. Data analysis included demographic data, risk factors, diagnostic workup, outcome. During period, 45 developed proven mucormycosis according EORTC/MSG criteria (2008). Ninety percentof cases were of...
To study the presenting signs of Retinoblastoma in Egypt at Egypt's main pediatric oncology referral center.This is a prospective descriptive (hospital-based registry) conducted Children's Cancer Hospital between July 2007 and December 2012.Out 262 patients diagnosed with retinoblastoma, 244 were suffering from intra-ocular disease presentation. One hundred thirty-nine (57%) presented unilateral disease, while 105 (43%) suffered bilateral disease. The mean age presentation was 20.6 ± 17...
Egypt shows a parallel increase in premenopausal breast cancer and environmental pollution. The purpose of this study is to explore possible relationship between oxidative DNA damage, urinary estrogen metabolites Egyptian women. We conducted pilot involving 29 cases 32 controls analysed lymphocyte levels 7,8-dihydro-8-oxo-2′-deoxyguanine (8-oxo-dG), measure damage using high performance liquid chromatography with electro-chemical detection (HPLC-ECD) method. metabolites, 2-hydroxyestrone...
Aggresomes are transient microtubule-dependent inclusion bodies that sequester misfolded proteins and ultimately removed by autophagy. Here we report the generation of a choroid plexus carcinoma cell line; Children's Cancer Hospital Egypt (CCHE)-45, which is characterized constitutive formation aggresomes. When examining autophagy pathway as main route for aggresomes clearance, CCHE-45 cells displayed increased flux mediated MAP1LC3B. MAP1LC3A-Variant1 gene expression was silenced promoter...
Background: Retinoblastoma poses a substantial burden in developing countries. We conducted this study to assess the effect of implementing multidisciplinary approach and standardized protocols for treating pediatric patients with retinoblastoma at Children’s Cancer Hospital Egypt (CCHE).Materials Methods: In January 2011, CCHE implemented diagnosis, treatment, reporting cases. The hospital also introduced new management algorithm data analysis system. study, we compared pathologic features,...
We describe an outbreak of mucormycosis in a pediatric oncology hospital during December 2010 and the measures taken to stop it. The began with two consecutive cases laboratory-documented infections within 1 week. Investigations track source were conducted immediately. Air plate cultures from machines ducts supplying patients' rooms revealed growth Rhizomucor. Of five affected patients, all had acute leukemia three histopathologically proven. All patients treated liposomal amphotericin B...
Background Pure germinomas account for 40% of pineal tumors and are characterized by the lack appreciable tumor markers, thus requiring a biopsy diagnosis. MicroRNAs (miRNA) have emerged as potential non-invasive biomarkers germ cell may facilitate diagnosis pure germinomas. Material methods A retrospective chart review was performed on all patients treated at Children’s Cancer Hospital Egypt diagnosed with region between June 2013 March 2021 whom research blood sample available. Plasma...
In children, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon subtype of lymphoma. Given the lack data on best chemotherapy regimen, there a knowledge gap in management.