A5086525008- Carcinogens and Genotoxicity Assessment
- PI3K/AKT/mTOR signaling in cancer
- Cytokine Signaling Pathways and Interactions
- Cancer, Lipids, and Metabolism
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- Diet and metabolism studies
- DNA Repair Mechanisms
- Metabolism, Diabetes, and Cancer
- NF-κB Signaling Pathways
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Chemokine receptors and signaling
- Cancer, Hypoxia, and Metabolism
- Skin Protection and Aging
- Prostate Cancer Treatment and Research
- Sirtuins and Resveratrol in Medicine
- Ginger and Zingiberaceae research
- Kruppel-like factors research
- Natural product bioactivities and synthesis
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- Growth Hormone and Insulin-like Growth Factors
- Fungal Plant Pathogen Control
The University of Texas at Austin
2016-2025
Austin College
2011-2025
Texas College
2025
Livestrong Foundation
2020-2024
Dell Children's Medical Center of Central Texas
2024
Clinical Research Management
2022
Georgetown University
2019
University of Colorado Anschutz Medical Campus
2019
National Cancer Institute
2018
The University of Texas MD Anderson Cancer Center
2004-2015
Plasmacytoid dendritic cells (pDCs) are specialized type I interferon (IFN-α/β)–producing that express intracellular toll-like receptor (TLR) 7 and TLR9 recognize viral nucleic acids in the context of infections. We show pDCs also have ability to sense host-derived released common skin wounds. were found rapidly infiltrate both murine human wounds transiently produce IFNs via TLR7- TLR9-dependent recognition acids. This process was critical for induction early inflammatory responses...
Constitutive activation of signal transducer and activator transcription 3 (Stat3) has been found in a wide spectrum human malignancies. Here, we have assessed the effect Stat3 deficiency on skin tumor development using 2-stage chemical carcinogenesis model. The epidermis Stat3-deficient mice showed significantly reduced proliferative response following treatment with promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because defect G1-to-S-phase cell cycle progression. Treatment initiator...
Constitutive activation of signal transducer and activator transcription 3 (Stat3) has been found in a wide spectrum human malignancies. Here, we have assessed the effect Stat3 deficiency on skin tumor development using 2-stage chemical carcinogenesis model. The epidermis Stat3-deficient mice showed significantly reduced proliferative response following treatment with promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because defect G1-to-S-phase cell cycle progression. Treatment initiator...
Transgenic mice expressing human insulin-like growth factor 1 (IGF-1) in basal epithelial cells of prostate have been characterized. Transgene expression led to activation the IGF-1 receptor and spontaneous tumorigenesis epithelium. Hyperplasia was evident these by 2–3 months age. Atypical hyperplasias prostatic intraepithelial neoplasia were 6–7 Well differentiated adenocarcinomas appeared 6 or older. Less tumors, diagnosed as small cell carcinomas, also observed two older mice. Both lobes...
Development of a suitable mouse model would facilitate the investigation pathomechanisms underlying human psoriasis and also assist in development therapeutic treatments. However, while many models have been proposed, no single recapitulates all features disease, standardized validation criteria for not widely applied. In this study, whole-genome transcriptional profiling is used to compare gene expression patterns manifested by psoriatic skin lesions with those that occur five (K5-Tie2,...
The prevalence of obesity, an established risk factor for several types cancer, has increased steadily over the past decades in United States. New targets and strategies offsetting effect obesity on cancer are urgently needed. In present study, we examined dietary energy balance manipulation steady-state signaling multiple epithelial tissues, with a focus Akt mammalian target rapamycin (mTOR) pathways. For these experiments, male FVB/N C57BL/6 female ICR mice were maintained control (10...
Psoriasis is an inflammatory disease with dynamic interactions between the immune system and skin. The IL-23/Th17 axis plays important role in pathogenesis of psoriasis, although exact contributions IL-23 IL-17 vivo remain unclear. K5.Stat3C transgenic mice constitutively express activated Stat3 within keratinocytes, these animals develop skin lesions histological cytokine profiles similar to those human plaque psoriasis. In this study, we characterized effects anti-mouse IL-17A,...
Despite much recent progress, prostate cancer continues to represent a major cause of cancer-related mortality and morbidity in men. Prostate is the most common nonskin neoplasm second leading death 6-Shogaol (6-SHO), potent bioactive compound ginger (Zingiber officinale Roscoe), has been shown possess anti-inflammatory anticancer activity. In present study, effect 6-SHO on growth cells was investigated. effectively reduced survival induced apoptosis cultured human (LNCaP, DU145, PC3) mouse...
Abstract To follow‐up on our previous report that acarbose (ACA), a drug blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose), and 2,500 ppm, using genetically heterogeneous mice sites. Each dose led to significant change (by log‐rank test) in both sexes, with larger effects males, consistent the report. There were no differences among doses. The two higher doses produced 16% or 17% median longevity of but only 4% 5%...
Obesity is a prognostic risk factor in the progression of prostate cancer; however, molecular mechanisms involved are unclear. In this study, we provide preclinical proof concept for role proinflammatory CXCL12-CXCR4/CXCR7 signaling axis an obesity-driven mouse model myc-induced cancer. Analysis stromal vascular fraction from periprostatic white adipose tissue obese HiMyc mice at 6 months age revealed dramatic increase mRNAs encoding various chemokines, cytokines, growth factors, and...
Abstract In the present study, we have investigated possible role of signal transducers and activators transcription (STATs), particularly Stat3, in mouse skin tumor promotion multistage carcinogenesis. Stat1, Stat5 were activated epidermis after treatment with different classes promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, chrysarobin. addition, constitutively tumors generated by two-stage carcinogenesis regimen using 7,12-dimethylbenz(a)anthracene as...