A5009711079- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Genetics, Bioinformatics, and Biomedical Research
- Chromatin Remodeling and Cancer
- Protein Degradation and Inhibitors
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Developmental Biology and Gene Regulation
- Hedgehog Signaling Pathway Studies
- Microtubule and mitosis dynamics
- Congenital heart defects research
- Circular RNAs in diseases
- Advanced Breast Cancer Therapies
- Bioinformatics and Genomic Networks
- Pluripotent Stem Cells Research
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Infection Control and Ventilation
- Genomic variations and chromosomal abnormalities
- COVID-19 epidemiological studies
- Genomics and Rare Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cell Image Analysis Techniques
- COVID-19 and healthcare impacts
Fusion Academy
2021-2022
Fusion (United States)
2021-2022
BioFluidica (United States)
2021-2022
Boston Children's Hospital
2011-2021
Broad Institute
2015-2021
Harvard University
2012-2021
Massachusetts Institute of Technology
2018
Johns Hopkins Medicine
2018
Johns Hopkins University
2018
Boston Children's Museum
2013-2016
Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma genes have not been defined and screening guidelines for genetic counselling testing paediatric patients are available. We aimed to assess define these provide evidence future guidelines.
Medulloblastoma is the most frequent malignant pediatric brain tumor and divided into at least four subgroups known as WNT, SHH, Group 3, 4. Here, we characterized gene regulation mechanisms in aggressive subtype, 3 tumors, through genome-wide chromatin expression profiling. Our results show that active distal sites these tumors are occupied by transcription factor OTX2. Highly OTX2-bound enhancers often arranged clusters of adjacent peaks also bound NEUROD1. These responsive to OTX2 NEUROD1...
Abstract Purpose: We used human stem and progenitor cells to develop a genetically accurate novel model of MYC-driven Group 3 medulloblastoma. also developed new informatics method, Disease-model Signature versus Compound-Variety Enriched Response (“DiSCoVER”), identify therapeutics that target this specific disease subtype. Experimental Design: Human neural derived from the cerebellar anlage were transduced with oncogenic elements associated aggressive An in silico analysis method for...
Article Tools UNDERSTANDING THE PATHWAY OPTIONS & TOOLS Export Citation Track Add To Favorites Rights Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2011.41.1181 Journal of Clinical Oncology - published online before print April 16, 2012 PMID: 22508821 Hedgehog-GLI Pathway in Medulloblastoma Tenley C. ArcherxTenley ArcherSearch for by this author , Shyamal D. WeeraratnexShyamal WeeraratneSearch Scott L. PomeroyxScott PomeroySearch Show More Children's...
Cancer systems biology aims to understand cancer as an integrated system of genes, proteins, networks, and interactions rather than entity isolated molecular cellular components. The inaugural Systems Approaches Biology Conference, cosponsored by the Association Early Career Biologists National Institute NIH, focused on interdisciplinary field challenging questions that are best addressed through combination experimental computational analyses. Attendees found elucidating many features...
The coronavirus disease 2019 (COVID-19) Exposure Assessment Tool (CEAT) allows users to compare respiratory relative risk severe acute syndrome 2 (SARS-CoV-2) for various scenarios, providing understanding of how combinations protective measures affect risk. CEAT incorporates mechanistic, stochastic, and epidemiological factors including the (i) emission rate virus, (ii) viral aerosol degradation removal, (iii) duration activity/exposure, (iv) inhalation rates, (v) ventilation rates...
Abstract Medulloblastoma is a pediatric brain tumor with poor overall survival and adverse long-term effects from current surgical radiation treatments. Our group has recently used expression copy number analysis to define six medulloblastoma subtypes, c1-c6. To assess whether these subgroups contain somatic mutations that encode potential therapeutic or diagnostic targets, we performed whole exome hybrid capture Illumina sequencing of 94 tumor/normal pairs. For each sample, sequenced...
7541 Background: Menin is a scaffold protein that drives oncogenic function through transcriptional modulation directed by its various cofactors. A previous report demonstrated menin regulates distinct set of gene targets independent with the MLL proteins in hematopoiesis and essential for B-cell maturation (Li et al. Blood.2013;122(12):2039-46.). Chronic Lymphocytic Leukemia (CLL) disease malignant B lymphocytes, which standard-of-care agents are generally well tolerated; however, CLL...