Divya Ramamoorthy
A5077495471- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Epigenetics and DNA Methylation
- Biochemical and Molecular Research
- Tissue Engineering and Regenerative Medicine
- Biochemical Acid Research Studies
- Prion Diseases and Protein Misfolding
- Plant biochemistry and biosynthesis
- Synthesis and biological activity
- Muscle Physiology and Disorders
- Chromatin Remodeling and Cancer
- Protein Structure and Dynamics
- 3D Printing in Biomedical Research
- Congenital Ear and Nasal Anomalies
- Seed Germination and Physiology
- Genomics and Rare Diseases
- interferon and immune responses
- Ginkgo biloba and Cashew Applications
- Parkinson's Disease Mechanisms and Treatments
- Craniofacial Disorders and Treatments
- Single-cell and spatial transcriptomics
- Antibiotic Resistance in Bacteria
- Computational Drug Discovery Methods
- Metabolism and Genetic Disorders
- Cleft Lip and Palate Research
Massachusetts Institute of Technology
2018-2024
IIT@MIT
2021-2022
Jawaharlal Nehru Medical College
2022
Datta Meghe Institute of Medical Sciences
2022
Moscow Institute of Thermal Technology
2020
University of South Florida
2009-2018
The University of Texas at Austin
2014-2015
John Wiley & Sons (United States)
2015
Bioengineering Center
2015
National Center for Genetic Engineering and Biotechnology
2015
Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons longitudinal smartphone over 1,000 patients with ALS. This provides population-level that may be employed to identify clinical-molecular-biochemical subtypes amyotrophic lateral sclerosis (ALS). A unique smartphone-based system was collect deep data, including fine motor activity, speech, breathing linguistics/cognition. The spinal were...
Abstract The clinical presentation of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, varies widely across patients, making it challenging to determine if potential therapeutics slow progression. We sought whether there were common patterns disease progression that could aid in the design and analysis trials. developed an approach based on mixture Gaussian processes identify clusters patients sharing similar patterns, modeling their average trajectories variability...
Neurodegenerative diseases are challenging for systems biology because of the lack reliable animal models or patient samples at early disease stages. Induced pluripotent stem cells (iPSCs) could address these challenges. We investigated DNA, RNA, epigenetics, and proteins in iPSC-derived motor neurons from patients with ALS carrying hexanucleotide expansions
Amyotrophic Lateral Sclerosis (ALS), like many other neurodegenerative diseases, is highly heritable, but with only a small fraction of cases explained by monogenic disease alleles. To better understand sporadic ALS, we report epigenomic profiles, as measured ATAC-seq, motor neuron cultures derived from diverse group 380 ALS patients and 80 healthy controls. We find that chromatin accessibility heavily influenced sex, the iPSC cell type origin, ancestry, inherent variance arising sequencing....
The National Institute of Health (NIH) Library integrated network-based cellular signatures (LINCS) program is premised on the generation a publicly available data resource cell-based biochemical responses or "signatures" to genetic environmental perturbations. NeuroLINCS uses human inducible pluripotent stem cells (hiPSCs), derived from patients and healthy controls, differentiated into motor neuron cell cultures. This multi-laboratory effort strives establish i) robust multi-omic workflows...
Successful cellular cardiomyoplasty is dependent on biocompatible materials that can retain the cells in myocardium order to promote host tissue repair following myocardial infarction. A variety of methods have been explored for incorporating a cell-seeded matrix into heart, most popular options being direct application an injectable system or surgical implantation patch. Fibrin-based gels are suitable either these approaches, as they and mechanical properties be tailored by adjusting...
The non-mevalonate dependent (NMVA) pathway for the biosynthesis of isopentenyl pyrophosphate and dimethylallyl is sole source these terpenoids production isoprenoids in apicomplexan parasites, many eubacteria, plants. absence this higher organisms has opened a new platform development novel antibiotics anti-malarials. enzyme catalyzing first step NMVA 1-deoxy-D-xylulose-5-phosphate synthase (DXPS). DXPS catalyzes thiamine pyrophosphate- Mg (II)-dependent conjugation pyruvate...
Humanity is burdened by malaria as millions are infected with this disease. Although advancements have been made in the treatment of malaria, optimism regarding our fight against must be tempered problem drug resistance Plasmodium parasites causing malaria. New targets required to overcome problem. The enzymes mevalonate-independent pathway isoprenoid biosynthesis for development novel antimalarial drugs. One enzyme pathway, 1-deoxy-d-xylulose-5-phosphate synthase (DXS), catalyzes conversion...
Mechanical forces play an important role in proper embryologic development, and similarly such can directly impact pluripotency differentiation of mouse embryonic stem cells (mESC) vitro. In addition, manipulation the embryoid body (EB) microenvironment, as by incorporation microspheres or microparticles, influence fate determination. this study, we developed a mechanical stimulation regimen using permanent neodymium magnets to magnetically attract within EB. Arginine-Glycine-Aspartic Acid...
FabH (Fatty acid biosynthesis, enzyme H, also referred to as β-ketoacyl-ACP-synthase III) is a key condensing in the type II fatty synthesis (FAS) system. The FAS pathway bacteria essential for growth and survival vastly differs from human pathway. Enzymes involved this have arisen promising biomolecular targets discovery of new antibacterial drugs. However, currently there are no clinical drugs that selectively target FabH, known inhibitors all act within active site. exerts its catalytic...
Abstract Answer ALS is a comprehensive multi-omics approach to ascertain, at population level, the various clinical-molecular- biochemical subtypes of sporadic ALS. This national program enrolled 1046 and ALS/FTD patients along with cohort 100 matched control followed longitudinally over least one year. A smartphone-based app was employed collect deep clinical data including fine motor activity, speech, breathing linguistics/cognition. Analytics speech patterns revealed strong correlation...
Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that complex in its onset, pattern of spread, and progression. The heterogeneity ALS makes it extremely challenging to determine if modifying therapy effectively slowing While accurately modeling progression critical developing therapeutics, current computational methods fail capture the complexity We aimed robustly characterize patterns ALS. obtained data from four clinical cohorts cover more than 3,500 patients...
Summary Neurodegenerative diseases present a challenge for systems biology, due to the lack of reliable animal models and difficulties in obtaining samples from patients at early stages disease, when interventions might be most effective. Studying induced pluripotent stem cell (iPSC)-derived neurons could overcome these challenges dramatically accelerate broaden therapeutic strategies. Here we undertook network-based multi-omic characterization iPSC-derived motor ALS carrying genetically...
Hemiarhinia is a rare congenital malformation of unknown aetiology, unilateral nasal aplasia that includes the absence an external nose and internal cavity. Around 75 cases have been reported to date. Here we presented case 2 years child who comes outpatient department with complaints deformity since birth. There were no associated symptoms deformity. anomalies. The was mentally normal, their growth within normal limits.