A5091055204- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- Pluripotent Stem Cells Research
- Protein Degradation and Inhibitors
- Renal and related cancers
- CRISPR and Genetic Engineering
- Pancreatic and Hepatic Oncology Research
- Antibiotic Resistance in Bacteria
- Epigenetics and DNA Methylation
- Advanced Breast Cancer Therapies
- Cancer Mechanisms and Therapy
- Cancer therapeutics and mechanisms
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Gastrointestinal Tumor Research and Treatment
- Pancreatic function and diabetes
- Lymphoma Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Multiple Myeloma Research and Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Use and Resistance
- Microtubule and mitosis dynamics
- Chromatin Remodeling and Cancer
- Bacterial Identification and Susceptibility Testing
- Chronic Myeloid Leukemia Treatments
Fusion (United States)
2021-2024
Fusion Academy
2021-2024
Amrita Vishwa Vidyapeetham
2021-2023
Tata Institute for Genetics and Society
2021-2023
BioFluidica (United States)
2022
Institute for Stem Cell Biology and Regenerative Medicine
2021
University of California, Davis
2017-2018
Shriners Hospitals for Children - Northern California
2017-2018
StemCells (United States)
2018
California Institute for Regenerative Medicine
2017
In India, multidrug resistance determinants are much more abundant in community-associated bacterial pathogens due to the improper treatment of domestic and industrial effluents. particular, a high load opportunistic pathogen P. aeruginosa sewage water bodies India is well documented.
The transcriptional functions of the class I histone deacetylases (HDACs) HDAC1 and HDAC2 are mainly viewed as both repressive redundant based on murine knockout studies, but they may have additional independent roles their physiological in human cells not clearly defined. To address individual epigenomic HDAC2, here we utilized CRISPR-Cas9 to disrupt cells. We find that while null exhibited signs cross-regulation between specific phenotypes were still apparent using RNA-seq ChIP assays....
Developmental pluripotency associated factor 4 (Dppa4) is a highly specific marker of pluripotent cells, and also overexpressed in certain cancers, but its function either these contexts poorly understood. In this study, we use ChIP-Seq to identify Dppa4 binding genome-wide three distinct cell types: mouse embryonic stem cells (mESC), embryonal carcinoma 3T3 fibroblasts ectopically expressing Dppa4. We find core set sites shared across types, substantial number unique each type. Across types...
Developmental Pluripotency-Associated-4 (DPPA4) is one of the few core pluripotency genes lacking clearly defined molecular and cellular functions. Here, we used a proteomics screening approach human embryonic stem cell (hESC) nuclear extract to determine DPPA4 functions through identification novel cofactors. Unexpectedly, signaling molecule ERBB3-binding protein 1 (EBP1) was strongest candidate binding partner for in hESC. EBP1 growth factor mediator present two isoforms, p48 p42. The...
Human pluripotent stem cells (hPSC) have great clinical potential through the use of their differentiated progeny, a population in which there is some concern over risks tumorigenicity or other unwanted cellular behavior due to residual hPSC. Preclinical studies using human are most often performed within xenotransplant context. In this study, we sought measure how undifferentiated hPSC behave following xenotransplant. We directly transplanted induced (hIPSC) and embryonic (hESC) into adult...
Abstract Objectives We sought to analyse the antibiotic susceptibility profiles and molecular epidemiology of MDR clinical Pseudomonas aeruginosa isolates from South India using non-MDR as a reference. Methods established comprehensive strain library consisting 58 collected patients across Indian state Kerala March 2017 July 2019. The strains were subject testing, modified carbapenem inactivation method assay for carbapenemase production, PCR sequencing, comparative sequence analysis...
Abstract Menin is an epigenetic protein that drives oncogenic function through transcriptional control directed by its various cofactors such as MLL1 (KMT2A) and MYC. BMF-219 a covalent menin inhibitor currently under investigation in dose-finding study evaluating safety tolerability adults with KRAS-driven Non-Small Cell Lung Cancer (NSCLC), Pancreatic Adenocarcinoma (PDAC), or Colorectal (CRC) (NCT NCT05631574). We previously showed induces effective killing of solid tumor cells...
7541 Background: Menin is a scaffold protein that drives oncogenic function through transcriptional modulation directed by its various cofactors. A previous report demonstrated menin regulates distinct set of gene targets independent with the MLL proteins in hematopoiesis and essential for B-cell maturation (Li et al. Blood.2013;122(12):2039-46.). Chronic Lymphocytic Leukemia (CLL) disease malignant B lymphocytes, which standard-of-care agents are generally well tolerated; however, CLL...
Abstract Chronic lymphocytic Leukemia (CLL) is the most common type of adult leukemia characterized by clonal proliferation malignant B-lymphocytes. Although standard-of-care agents are well tolerated in CLL, patients with certain genetic subsets disease continue to display poor response these therapeutic regimens. Menin an epigenetic protein that drives oncogenic function through transcriptional regulation directed its interactions various partners. In B-cell maturation pathway, menin...
Abstract Double/Triple Hit Lymphoma (DHL/THL) and Double Expressor (DEL) are high-grade B-cell lymphomas (HGBCL) that exhibit low responses to standard therapeutic regimens resulting in poor prognosis. DHL harbor translocations MYC BCL2 or BCL6, THL contain MYC/BCL2/BCL6, DEL characterized by high expression of BCL2. Menin is a scaffold protein drives oncogenic function through its regulation genes such as HOXA9, with distinct effects on transcription directed various cofactors. A recent...
Abstract Introduction: KRAS (Kirsten rat sarcoma virus) is the most frequently mutated isoform amongst RAS oncogenes in human solid tumors being present a high percentage of colorectal cancers (CRC), non-small cell lung (NSCLC), and pancreatic cancers. With only one approved G12C inhibitor for NSCLC, KRAS-driven continue to represent significant unmet medical need where novel effective therapies are highly desired. Menin required co-factor oncogenic transcriptional proteins with functional...