A5013473072- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Inflammatory Myopathies and Dermatomyositis
- Circadian rhythm and melatonin
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Neurofibromatosis and Schwannoma Cases
- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- Brain Metastases and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- interferon and immune responses
- Genetic Neurodegenerative Diseases
- Chromatin Remodeling and Cancer
- Neurological disorders and treatments
- Neurotransmitter Receptor Influence on Behavior
- Metabolism and Genetic Disorders
- Systemic Lupus Erythematosus Research
- Neuroscience and Neuropharmacology Research
- Parathyroid Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Toxoplasma gondii Research Studies
- Inflammasome and immune disorders
McMaster University
2017-2024
Shanghai University of Sport
2024
Hamilton Health Sciences
2018-2024
Hamilton Regional Laboratory Medicine Program
2020-2023
Hamilton General Hospital
2017-2023
Deleted Institution
2021-2023
National Institute of Neurological Disorders and Stroke
2023
Qilu Hospital of Shandong University
2016-2022
Shanxi Normal University
2022
Shandong University
2016-2022
The authors developed and applied two new linearized reference tissue models for parametric images of binding potential ( BP) relative delivery R 1 ) [ 11 C]DASB positron emission tomography imaging serotonin transporters in human brain. original multilinear model (MRTM O was modified (MRTM) used to estimate a clearance rate k′ 2 from the cerebellum (reference). Then, number parameters reduced three (MRTM2) by fixing . resulting BP estimates were compared with corresponding nonlinear models,...
Significance The pore-forming protein gasdermin D (GSDMD) was recently identified as the principal executioner of pyroptosis (“fiery death”), a type proinflammatory programmed cell death driven by inflammasomes. Caspase-1 cleaves GSDMD, but whether this process contributes to neuroinflammation is unknown. Here, we report evidence GSDMD-mediated primary mechanism inflammatory demyelination in central nervous system during multiple sclerosis (MS), debilitating and incurable demyelinating...
The suprachiasmatic nucleus (SCN), the circadian pacemaker for brain, provides a massive projection to subparaventricular zone (SPZ), but role of SPZ in processes has received little attention. We examined effects on rhythms sleep, body temperature, and activity rats restricted ibotenic acid lesions ventral or dorsal that spared immediately adjacent paraventricular hypothalamic (PVH) SCN. Ventral caused profound reduction measures index sleep (by 90%) locomotor (75% reduction) had less...
Abstract Motor fluctuations are a major disabling complication in the treatment of Parkinson's disease. To investigate whether such oscillations mobility can be attributed to changes synaptic levels dopamine, we studied prospectively patients early stages disease with follow‐up after at least 3 years levodopa treatment. At baseline, positron emission tomography (PET) scans using [ 11 C]raclopride before and (1 hour 4 hours) orally administered were performed on same day for each patient....
Motor fluctuations are a major disabling complication in the treatment of Parkinson's disease. To investigate whether such oscillations mobility can be attributed to changes synaptic levels dopamine, we studied prospectively patients early stages disease with follow-up after at least 3 years levodopa treatment. At baseline, positron emission tomography (PET) scans using [11C]raclopride before and (1 hour 4 hours) orally administered were performed on same day for each patient. Patients who...
Abstract Microbial communities reside in healthy tissues but are often disrupted during disease. Bacterial genomes and proteins detected brains from humans, nonhuman primates, rodents other species the absence of neurological We investigated composition abundance microbiota frozen fixed autopsied brain samples patients with multiple sclerosis (MS) age- sex-matched nonMS as controls, using neuropathological, molecular bioinformatics tools. 16s rRNA sequencing revealed Proteobacteria to be...
Abstract The derivation of dopamine neurons is one the best examples clinical potential embryonic stem (ES) cells, but long-term function grafted has not been established. Here, we show that, after transplantation into an animal model, derived from mouse ES cells survived for over 32 weeks, maintained midbrain markers, and had sustained behavioral effects. Microdialysis in animals showed that (DA) release was induced by depolarization pharmacological stimulants. Positron emission tomography...
To investigate the relationship between iron staining and magnetic resonance (MR) imaging measurements in postmortem subjects with multiple sclerosis (MS).Institutional ethical approval was obtained, informed consent obtained from and/or their families. Four MR methods based on transverse relaxation (T2 weighting, R2 mapping, R2* mapping) phase were performed by using a 4.7-T system three situ patients MS less than 28 hours after death one vivo patient 1 year before death. Iron Perls...
The phospholipase A2 (PLA2) superfamily hydrolyzes phospholipids to release free fatty acids and lysophospholipids, some of which can mediate inflammation demyelination, hallmarks the CNS autoimmune disease multiple sclerosis. expression two intracellular PLA2s (cPLA2 GIVA iPLA2 GVIA) secreted (sPLA2 GIIA sPLA2 GV) are increased in different stages experimental encephalomyelitis (EAE), an animal model We show using small molecule inhibitors, that cPLA2 plays a role onset, GVIA onset...
Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases such as multiple sclerosis (MS). However, this physiological mechanism has manifestations that range from impaired clearance unfolded proteins to altered mitochondrial dynamics and apoptosis. While connections between the triggering protein response (UPR) downstream dysfunction are poorly understood, membranous contacts ER mitochondria, called mitochondria-associated membrane (MAM), could provide functional link...
BackgroundMyotonic dystrophy type 1 (DM1) is a complex life-limiting neuromuscular disorder characterized by severe skeletal muscle atrophy, weakness, and cardiorespiratory defects. Exercised DM1 mice exhibit numerous physiological benefits that are underpinned reduced CUG foci improved alternative splicing. However, the efficacy of physical activity in patients unknown.MethodsEleven genetically diagnosed were recruited to examine extent which 12 weeks cycling can recuperate clinical...
Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these between living PD patients healthy subjects.Nicotinic were imaged 10 nondemented Parkinson's disease 15 age-matched subjects using a single-photon emission computed tomography ligand [(123)I]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine. Using an arterial input function, we measured total distribution volume (V;...
Abstract Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Neurosteroids are reported to exert anti‐inflammatory effects in several neurological disorders. We investigated expression and actions neurosteroid, dehydroepiandrosterone (DHEA), its more stable 3β‐sulphated ester, DHEA‐S, MS associated experimental models. CNS tissues from patients with animals autoimmune encephalomyelitis (EAE) displayed reduced DHEA concentrations, accompanied...
Classical neurosurgical teaching suggests that corticosteroid administration reduces the diagnostic yield of stereotactic brain biopsy for primary central nervous system lymphoma (PCNSL). In a single-center series spanning 6 years, we reviewed 155 consecutive patients, 135 treated with prebiopsy corticosteroids. PCNSL was correctly diagnosed on initial in 15 16 steroid-treated patients; single nondiagnostic specimen, polymerase chain reaction reanalysis by an outside institution showed...
Coronavirus disease 2019 (COVID-19) severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2 infection) can lead to intensive care unit (ICU) admission and critical illness myopathy (CIM). We examined 3 ICU patients with COVID-19 who required mechanical ventilation for pneumonia developed CIM. Pathological examination of the skeletal muscle biopsies revealed myopathic changes consistent CIM, variable inflammation autophagic vacuoles, SARS-CoV immunostaining + fibers/granules, electron...