A5005026882- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Nutrition and Health in Aging
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Spaceflight effects on biology
- Sports Performance and Training
- Cardiovascular Effects of Exercise
- Adipokines, Inflammation, and Metabolic Diseases
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Mitochondrial Function and Pathology
- Dietary Effects on Health
- Hematopoietic Stem Cell Transplantation
- Glycogen Storage Diseases and Myoclonus
- Muscle activation and electromyography studies
- Metabolism, Diabetes, and Cancer
- Lysosomal Storage Disorders Research
- Telomeres, Telomerase, and Senescence
- Genetic Neurodegenerative Diseases
- Pancreatic function and diabetes
- Biocrusts and Microbial Ecology
McMaster University Medical Centre
2018-2025
McMaster University
2015-2024
Health Sciences Centre
2018-2023
McMaster Children's Hospital
2022
Maastricht University
2019
International College of Applied Kinesiology-USA
2016-2018
Western University
2012-2017
Abstract Background Adequate muscle fibre perfusion is critical for the maintenance of mass; it essential in rapid delivery oxygen, nutrients and growth factors to muscle, stimulating growth. Muscle capillarization known decrease substantially with advancing age. However, whether (relative) low negatively impacts hypertrophic response following resistance exercise training older adults unknown. Methods Twenty‐two healthy men (71 ± 1 years) performed 24 weeks progressive type training. To...
Skeletal muscle satellite cells (SC) are instrumental in maintenance of fibres, the adaptive responses to exercise, and there is an age-related decline SC. A spatial relationship exists between SC fibre capillaries. In present study, we aimed investigate whether chronologic age has impact on Secondly, determined this changes response a single session resistance exercise.Muscle biopsies were obtained from vastus lateralis previously untrained young men (YM, 24 ± 3 years; n = 23) older (OM, 67...
Biological aging is associated with progressive damage accumulation, loss of organ reserves, and systemic inflammation ('inflammaging'), which predispose for a wide spectrum chronic diseases, including several types cancer. In contrast, aerobic exercise training (AET) reduces inflammation, lowers all-cause mortality, enhances both health lifespan. this study, we examined the benefits early-onset, lifelong AET on predictors health, cancer incidence in naturally mouse model (C57BL/J6)....
Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) supplementation partially protect against sarcopenia under controlled conditions, the efficacy of home-based, unsupervised RE (HBRE) multi-ingredient (MIS) largely unknown. In this randomized, placebo-controlled double-blind trial, we examined effects HBRE/MIS on mass, strength,...
Aging | doi:10.18632/aging.204435. Kevin Perez, Serban Ciotlos, Julia McGirr, Chandani Limbad, Ryosuke Doi, Joshua P. Nederveen, Mats I. Nilsson, Daniel A. Winer, William Evans, Mark Tarnopolsky, Judith Campisi, Simon Melov
The age-related loss of skeletal muscle mass and functionality, known as sarcopenia, is a critical risk factor for morbidity all-cause mortality. Resistance exercise training (RET) the primary countermeasure to fight sarcopenia ageing. Altered intercellular communication hallmark ageing, which not well elucidated. Circulating extracellular vesicles (EVs), including exosomes, contribute by delivering microRNAs (miRNAs), modulate post-translational modifications, have been shown be released...
Skeletal muscle possesses the ability to regenerate after injury, but this is impaired or delayed with aging. Regardless of age, retains positively respond stimuli, such as exercise. We examined whether exercise able improve regenerative response in skeletal aged mice. Twenty-two-month-old male C57Bl/6J mice (n = 20) underwent an 8-wk progressive training protocol [old exercised (O-Ex) group]. An old sedentary (O-Sed) and a young control (Y-Ctl) group were included. Animals subjected...
Skeletal muscle stem cells (satellite cells) play a crucial role in repair and remodelling of response to exercise. Satellite are close spatial proximity capillaries therefore may be influenced by them. In this study, we describe the activation expansion satellite cell pool eccentric contraction-induced damage individuals with significantly different levels capillarization. Individuals greater capillarization capacity for perfusion demonstrated enhanced and/or allowing an accelerated...
BackgroundMyotonic dystrophy type 1 (DM1) is a complex life-limiting neuromuscular disorder characterized by severe skeletal muscle atrophy, weakness, and cardiorespiratory defects. Exercised DM1 mice exhibit numerous physiological benefits that are underpinned reduced CUG foci improved alternative splicing. However, the efficacy of physical activity in patients unknown.MethodsEleven genetically diagnosed were recruited to examine extent which 12 weeks cycling can recuperate clinical...
Skeletal muscle satellite cells (SC) play an important role in adaptation. In untrained individuals, SC content and activation status have been observed to increase response a single bout of exercise. Muscle fiber characteristics change considerably when resistance exercise is performed chronically, but whether training affects the activity remains unknown. We examined changes following exercise, before 16-wk progressive (RT) program 14 young (25 ± 3 yr) men. Before after RT, percutaneous...
The purpose of the present studies was to determine effect various nonhypertrophic exercise stimuli on satellite cell (SC) pool activity in human skeletal muscle. Previously untrained men and women (men: 29 ± 9 yr women: 2 yr, n = 7 each) completed 6 wk very low-volume high-intensity sprint interval training. In a separate study, recreationally active (n 16) 3) either traditional moderate-intensity continuous 9, 21 4 yr) or training 10, yr). Muscle biopsies were obtained from vastus...
Key points Skeletal muscle stem cells, termed satellite play a crucial role in repair and remodelling of response to exercise An age‐related decline cell number and/or function has been hypothesized be key factor the development sarcopenia blunted fibre adaptive prolonged training older persons We report that performing improves acute type II following single bout resistance men. The observed improvement is associated with an increase capillarization suggesting possible functional link...
Satellite cells (SC) are associated with skeletal muscle remodelling after damage and/or extensive hypertrophy resulting from resistance training (RT). We recently reported that early increases in protein synthesis (MPS) during RT appear to be directed toward repair, but MPS contributes progressive attenuation. However, modulations acute-chronic SC content the initial (1st-wk: high damage), (3rd-wk: attenuated and later (10th-wk: no damage) stages is not well characterized. Ten young men (27...
Exercise positively impacts mood and symptoms of depression; however, the mechanisms underlying these effects are not fully understood. Recent evidence highlights a potential role for skeletal muscle-derived transcription factors to influence tryptophan metabolism, along kynurenine pathway, which has important implications in depression. This consequences older adults, whose age-related muscle deterioration may this pathway increase their risk Although exercise training been shown improve...
Fatty acids are vital for the survival of eukaryotes, but when present in excess can have deleterious consequences. The AMP-activated protein kinase (AMPK) is an important regulator multiple branches metabolism. Studies purified enzyme preparations and cultured cells shown that AMPK allosterically activated by small molecules as well fatty acyl-CoAs through a mechanism involving Ser108 within regulatory β1 isoform. However, vivo physiological significance this residue has not been evaluated....
Trophoblast differentiation is a crucial process in the formation of placenta where cytotrophoblasts (CTs) differentiate and fuse to form syncytiotrophoblast (ST). The bioactive components cannabis, such as Δ
ABSTRACT Background Spinal muscular atrophy (SMA) is a health‐ and life‐limiting neuromuscular disorder. Although varying degrees of mitochondrial abnormalities have been documented in SMA skeletal muscle, the influence disease progression on pathways that govern organelle turnover dynamics are poorly understood. Thus, purpose this study was to investigate muscle mitochondria during determine effects therapeutic modalities biology. Methods Smn 2B/+ 2B/− severe SMA‐like mice were used...
A dysregulation of satellite cells may contribute to the progressive loss muscle mass that occurs with age; however, older adults retain ability activate and expand their cell pool in response exercise. The modality exercise capable inducing greatest acute is unknown. We sought characterize following different modes adults.Sedentary men (n = 22; 67 ± 4 years; 27 2.6 kg*m(-2) ) were randomly assigned complete an bout either resistance exercise, high-intensity interval on a cycle ergometer or...
High-intensity interval training (HIIT) enhances skeletal muscle oxygen delivery and utilization but data are limited regarding fiber-specific adaptations in humans. We examined the effect of 18 sessions HIIT (10 × 60-sec cycling intervals at ~90% HRmax, interspersed by recovery) over 6 weeks on markers microvascular density oxidative capacity type I II fibers healthy sedentary young women (Age: 26 ± 7 years; BMI: 30 4 kg·m−2; VO2peak: 2.16 0.45 L·m−1). Immunohistochemical analyses cross...
The percutaneous muscle biopsy procedure is an invaluable tool for characterizing skeletal and capillarization. Little known about methodological or biological variation stemming from the technique in heterogeneous muscle. Five biopsies were taken vastus lateralis of a group young men (n = 29, 22 ± 1 years) over 96-h period. We investigated repeatability fibre distribution, indices capillarization perfusion, myofibre characteristics. No differences between reported type cross-sectional area...
The purpose of this study is to investigate exosome-like vesicle (ELV) plasma concentrations and markers multivesicular body (MVB) biogenesis in skeletal muscle response acute exercise. Seventeen healthy [body mass index (BMI): 23.5 ± 0.5 kg·m-2] 15 prediabetic (BMI: 27.3 1.2 kg·m-2) men were randomly assigned two groups performing an cycling bout normoxia or hypoxia ([Formula: see text] 14.0%). Venous blood samples taken before (T0), during (T30), after (T60) exercise, biopsies from m....