A5088969945- Pluripotent Stem Cells Research
- Neurotransmitter Receptor Influence on Behavior
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- CRISPR and Genetic Engineering
- Nuclear Receptors and Signaling
- Biochemical and biochemical processes
- Inflammation biomarkers and pathways
- Biochemical Acid Research Studies
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Ion channel regulation and function
- Liver Disease Diagnosis and Treatment
- Synthesis and biological activity
- Selenium in Biological Systems
- Antiplatelet Therapy and Cardiovascular Diseases
- Regulation of Appetite and Obesity
- Hemoglobin structure and function
- Advanced Glycation End Products research
- Endoplasmic Reticulum Stress and Disease
- Neuroscience of respiration and sleep
- Inflammatory mediators and NSAID effects
- Folate and B Vitamins Research
- Prenatal Substance Exposure Effects
Lund University
2025
Universidad de Sevilla
1996-2024
Instituto de Biomedicina de Sevilla
2011-2024
Hospital Universitario Virgen del Rocío
2011-2024
Consejo Superior de Investigaciones Científicas
2017
Biomedical Research Networking Center on Neurodegenerative Diseases
2015
Centro de Investigación Biomédica en Red
2011
National Institute of Neurological Disorders and Stroke
2002-2006
National Institutes of Health
2006
Abstract The derivation of dopamine neurons is one the best examples clinical potential embryonic stem (ES) cells, but long-term function grafted has not been established. Here, we show that, after transplantation into an animal model, derived from mouse ES cells survived for over 32 weeks, maintained midbrain markers, and had sustained behavioral effects. Microdialysis in animals showed that (DA) release was induced by depolarization pharmacological stimulants. Positron emission tomography...
Abstract Despite the different animal models of Parkinson's disease developed during last years, they still present limitations modelling slow and progressive process neurodegeneration. Here, we undertook a histological, neurochemical behavioural analysis new chronic parkinsonian mouse model generated by subcutaneous administration low doses MPTP (20 mg/kg, 3 times per week) for months, using both young adult aged mice. The ‐induced nigrostriatal neurodegeneration was accompanied decrease in...
Experimental Neuroinflammation Laboratory, Department of Medical Science, Lund University, Lund, Sweden (García-Revilla J) Instituto de Biomedicina Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad Seville, Spain J, Venero JL, Rodríguez-Gómez JA) Departamento Bioquímica y Biología Molecular, Facultad Farmacia, Universidad *Correspondence to: Jose Luis Venero, PhD, [email protected]. This is an open access journal, and articles are distributed under the terms Creative...
Neuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson's disease (PD), and seems to play key role in their development progression. Microglia cells, the principal orchestrators of neuroinflammation, can be polarized different phenotypes, which means they are able have anti-inflammatory, pro-inflammatory, or effects. Increasing evidence supports that traditional Mediterranean dietary pattern related reduction cognitive decline diseases. A considerable...
Ion channels participate in cell homeostasis and are involved the regulation of proliferation differentiation several types; however, their presence function embryonic stem (ES) cells poorly studied. We have investigated existence voltage-dependent inward currents mouse ES ability to modulate self-renewal. Patch-clamped had inactivating tetrodotoxin (TTX)-sensitive Na + as well transient Ca 2+ abolished by external application Ni . Biophysical pharmacological data indicated that current is...
Coenzyme Q10 (CoQ10 ) plays a crucial role in mitochondria as an electron carrier within the mitochondrial respiratory chain (MRC) and is essential antioxidant. Mutations genes responsible for CoQ10 biosynthesis (COQ genes) cause primary deficiency, rare heterogeneous disorder with no clear genotype-phenotype association, mainly affecting tissues high-energy demand including brain skeletal muscle (SkM). Here, we report four-year-old girl diagnosed minor mental retardation lethal...
Key points Biotin, a vitamin whose main role is as coenzyme for carboxylases, accumulates at unusually large amounts within cells of the carotid body (CB). In biotin‐deficient rats biotin rapidly disappears from blood; however, it remains relatively high levels in CB glomus cells. The contains mRNA SLC5a6, transporter, and SLC19a3, thiamine transporter regulated by biotin. Animals with deficiency exhibit pronounced metabolic lactic acidosis. Remarkably, these animals have normal electrical...
Abstract We have studied the turnover of dopamine, noradrenaline, and serotonin their metabolites in hippocampus adult female rats that were fed control or selenium‐deficient diets during 15 days. Under these circumstances, there was an increase dopamine (4‐fold) with diet respect to controls also tyrosine hydroxylase activity (75.8%), which result amount enzyme (2‐fold), without significant change phosphorylation hydroxylase. In addition glutathione peroxidase, reductase, catalase,...
1. We have studied the effect of (-)-deprenyl on oxidative damage that rat substantia nigra suffers during aging. 2. (-)-Deprenyl (2 mg kg-1, three times a week) administered for two months, beginning at 22 months age, produced significant increase in tyrosine hydroxylase (TH) activity (2.67 +/- 0.40 and 3.64 0.38 nmol mg-1 protein h-1 untreated aged rats treated respectively, P < 0.05) TH amount (0.072 0.012 0.128 absorbance 405 nm 0.05). 3. The proteins showed decrease carbonyl groups...
Discovery of haemoglobin A expression outside the erythroid cell lineage suggests that oxygen transport is main, but not unique, function adult chains in mammals. The contribution to antioxidant defences has been proposed territories where it expressed. Catecholaminergic cells rely on an active oxidative metabolism accomplish their biological function, are exposed strong stress due catecholaminergic transmitters. We show present study peripheral catecholaminegic express α- and β-haemoglobin...
We have studied the effect of chronic treatment with nomifensine on dopaminergic functioning in nigrostriatal system. The striatal system was not altered by treatment. In contrast, there were overall decreases different dopamine (DA) metabolites cell body region substantia nigra after treatment, which clearly indicates a diminished DA turnover. These results suggest that long-lasting inhibition high affinity uptake triggers long term regulatory, compensatory mechanisms to preserve normal...