A5012818762- Tryptophan and brain disorders
- Nitric Oxide and Endothelin Effects
- Antioxidant Activity and Oxidative Stress
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Wastewater Treatment and Nitrogen Removal
- Enzyme Production and Characterization
- Phytochemicals and Antioxidant Activities
- Amino Acid Enzymes and Metabolism
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Biochemical Acid Research Studies
- Stress Responses and Cortisol
- GABA and Rice Research
- Regulation of Appetite and Obesity
- Neurogenesis and neuroplasticity mechanisms
- Metabolomics and Mass Spectrometry Studies
- Sulfur Compounds in Biology
- Skin Protection and Aging
- Cardiac Arrhythmias and Treatments
- Phytase and its Applications
- Edible Oils Quality and Analysis
Hospital Universitario Virgen de las Nieves
2023
Universidad de Sevilla
2009-2021
Molina Center for Energy and the Environment
2007
Consejo Superior de Investigaciones Científicas
1986
Abstract Increased neuroinflammatory reaction is frequently observed during normal brain aging. However, a direct link between neuroinflammation and neurodegeneration aging has not yet been clearly shown. Here, we have characterized the age‐related hippocampal inflammatory processes potential relation with neurodegeneration. The mRNA expression of pro‐inflammatory cytokines IL‐1β tumor necrosis factor‐α (TNF‐α), iNOs enzyme was significantly increased in aged hippocampus. Accordingly,...
Leptin is a protein involved in the regulation of food intake and immune inflammatory responses, among other functions. Evidences demonstrate that obesity directly associated with high levels leptin, suggesting leptin may link elevated cardiovascular renal risk increased body weight. Adverse effects include oxidative stress mediated by activation NADPH oxidase. The aim this study was to evaluate effect L-carnitine (LC) rat epithelial cells (NRK-52E) exposed order generate state...
This work presents a new bioprocess process for the extraction of bioactive components from soy pulp by-product (okara) using an enzymatic technology that was compared to conventional water extraction. Okara is rich in fiber, fat, protein, and compounds such as isoflavones but its low solubility hampers use food fertilizer industry. After attack with endoproteases half original insoluble proteins were converted into soluble peptides. Linked this occured solubilization trapped protein matrix....
We have investigated the age-dependent modifications in expression of eight different subunits γ-aminobutyric acid, type A (GABA<sub>A</sub>) receptor (α1, α2, α3, α5, β2, β3, γ2S, and γ2L) all four α-amino-3-hydroxy-5-methylsoxazole-4-propionate (AMPA) (GluR1–4) hippocampus 24-month-old rats. All aged hippocampi displayed a remarkable increase (aged/adult ratio, 3.53 ± 0.54) mRNA levels short version γ2 subunit parallel with similar protein 2.90 0.62). However, this was not observed mature...
Cu/Zn‐Superoxide dismutase activity (Cu/Zn‐SOD) was studied in liver from 3‐ and 24‐month‐old rat. A significant decrease of enzyme the aged rat found. Various amino acid residues protein carbonyl groups (CO) were measured purified young old enzyme. It found that ‘old’ had one histidine fewer higher CO content than ‘young’ Cu/Zn‐SOD. Inactivation ‘in vitro’ commercial bovine erythrocyte Cu/Zn‐SOD led to a enzymatic activity, an increase residue modified. similar behavior between aging...
Abstract We have studied the turnover of dopamine, noradrenaline, and serotonin their metabolites in hippocampus adult female rats that were fed control or selenium‐deficient diets during 15 days. Under these circumstances, there was an increase dopamine (4‐fold) with diet respect to controls also tyrosine hydroxylase activity (75.8%), which result amount enzyme (2‐fold), without significant change phosphorylation hydroxylase. In addition glutathione peroxidase, reductase, catalase,...
1. We have studied the effect of (-)-deprenyl on oxidative damage that rat substantia nigra suffers during aging. 2. (-)-Deprenyl (2 mg kg-1, three times a week) administered for two months, beginning at 22 months age, produced significant increase in tyrosine hydroxylase (TH) activity (2.67 +/- 0.40 and 3.64 0.38 nmol mg-1 protein h-1 untreated aged rats treated respectively, P < 0.05) TH amount (0.072 0.012 0.128 absorbance 405 nm 0.05). 3. The proteins showed decrease carbonyl groups...
Ozone is a destructive pollutant, damaging crops, and decreasing crop yield. Therefore, there great interest in finding strategies to alleviate ozone-induced losses. In plants, ozone enters leaves through the stomata immediately degraded into reactive oxygen species (ROS), producing ROS stress plants. can be controlled by ROS-scavenging systems that include enzymatic or non-enzymatic mechanisms. Our research group has developed product from rice bran, by-product of milling which bioactive...
1-methyl-4-phenylpyridinium (MPP+) is the bioactivated product of 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyri dine (MPTP). The neurotoxic action MPP+ injected intracerebroventricularly (ICV) in rat has been stud ied, using dopaminergic systems substantia nigra, striatum, olfactory bulb, median eminence and hypoph ysis. following results were obtained: (1) Rats with ICV administration 1 μl solution (62.5 μg rat) showed 50% mortality; (2) produced a decrease dopamine (DA) concentra tion...
AbstractSuperoxide dismutase activity was measured in liver and lung from 3 24 month-old rats. Both total SOD Mn-SOD decreased significantly the of old Recent results our laboratory have indicated that during aging, Cu/Zn-SOD decreases rat there is an accumulation altered protein. It also shown had one histidine fewer than young one. In present study, immunoprecipitation experiments showed amount immunoprecipitable rats greater ones, but when amino acid residues were purified liver, no...