A5085117203- Pregnancy and preeclampsia studies
- Metabolism and Genetic Disorders
- Metabolomics and Mass Spectrometry Studies
- Nitric Oxide and Endothelin Effects
- Ion Transport and Channel Regulation
- Cholesterol and Lipid Metabolism
- Technology in Education and Healthcare
- Diet, Metabolism, and Disease
- Retinal Diseases and Treatments
- Diet and metabolism studies
- Higher Education Teaching and Evaluation
- Edible Oils Quality and Analysis
- Glaucoma and retinal disorders
- Health and Medical Education
- Developmental and Educational Neuropsychology
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pancreatic function and diabetes
- Antioxidant Activity and Oxidative Stress
- Neurological Complications and Syndromes
- Reproductive System and Pregnancy
- E-Learning and Knowledge Management
- Angiogenesis and VEGF in Cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Communication and COVID-19 Impact
Hospital Universitario Virgen del Rocío
2015-2025
Consejo Superior de Investigaciones Científicas
2020-2025
Universidad de Sevilla
2016-2025
Instituto de Biomedicina de Sevilla
2015-2025
University of Zurich
2004
Captopril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the treatment of arterial hypertension and cardiovascular diseases. Our objective was to study whether captopril able attenuate cardiac inflammatory process associated with hypertension.Left ventricle mRNA expression plasma levels pro-inflammatory (interleukin-1beta (IL-1beta) IL-6) anti-inflammatory (IL-10) cytokines, were measured spontaneously hypertensive rats (SHR) their control normotensive, Wistar-Kyoto (WKY)...
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The mechanism(s) underlying the effects of L-carnitine (beta-hydroxy-gamma-N-trimethylammonium-butyrate; LC) in cardiovascular diseases are not well clarified. Previous studies have demonstrated that oxidative stress and inflammation contribute to arterial hypertension, antioxidant and/or anti-inflammatory therapies been proposed. We hypothesized LC might attenuate hypertensive status through an inhibition process.Heart mRNA expression plasma levels inflammatory markers, interleukin-1 beta...
Abstract Arterial hypertension leads to oxidative and inflammatory imbalances, triggering hypertensive organ damage through several pathways. We have previously described the antioxidant anti‐inflammatory properties of olive oil extracted from wild tree ( Olea europaea var. sylvestris , acebuche, ACE) against ocular damage. The aim this study was clarify molecular mechanisms involved in beneficial effect ACE on eyes, focusing nitric oxide (NO)/arginine metabolism. To end, we used retinal...
The development of renal fibrosis is a consequence arterial hypertension. L-carnitine plays an essential role in the β-oxidation fatty acids, and we have previously demonstrated hypotensive, antioxidant, anti-inflammatory effects This work aims to analyze effect on explore participation peroxisome-proliferator activated receptor (PPAR)-γ this effect.Four groups or rats were used: control, treated with L-carnitine, L-NAME, + L-NAME. Cultured rat kidney cells also used examine PPAR-γ effect.An...
Leptin is a protein involved in the regulation of food intake and immune inflammatory responses, among other functions. Evidences demonstrate that obesity directly associated with high levels leptin, suggesting leptin may link elevated cardiovascular renal risk increased body weight. Adverse effects include oxidative stress mediated by activation NADPH oxidase. The aim this study was to evaluate effect L-carnitine (LC) rat epithelial cells (NRK-52E) exposed order generate state...
Background. In patients undergoing peritoneal dialysis (PD), low-calcium dialysate (LCD) has been proposed as the first choice for a better control of renal osteodystrophy. Our aim was to compare effects on bone metabolism LCD (calcium: 1.25 mmol/l) with that standard calcium (SCD; calcium: 1.75 mmol/l). Methods. Forty-four PD were randomized receive or continue SCD period 12 months. Bone biopsies taken at baseline and Biochemical data treatment evaluated every 3 Results. Twenty-four...
Preeclampsia (PE) is a pregnancy-specific disorder characterized by the new onset of hypertension plus proteinuria and/or end-organ dysfunction. Here, we investigate role nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system as major component reactive oxygen species generation, in rodent model early-onset preeclampsia induced excess sFlt1 (soluble fms-like tyrosine kinase 1). Placenta and kidney samples were obtained from normal pregnant PE rats to measure sFlt1/PlGF (placental...
Hepatocytes and cholangiocytes release ATP into bile, where it is rapidly degraded adenosine P(i). In rat, biliary P(i) concentration (0.01 mM) approximately 100-fold 200-fold lower than in hepatocytes plasma, respectively, indicating active reabsorption of We aimed to functionally characterize canalicular rat liver identify the involved transport system(s). was determined isolated plasma membrane (LPM) vesicles using a rapid filtration technique. Identification putative transporters...