A5002035651- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Pregnancy and preeclampsia studies
- Fatty Acid Research and Health
- Diet, Metabolism, and Disease
- Ion Transport and Channel Regulation
- Metabolism and Genetic Disorders
- Clinical Nutrition and Gastroenterology
- Pancreatic function and diabetes
- Nitric Oxide and Endothelin Effects
- Metabolomics and Mass Spectrometry Studies
- Essential Oils and Antimicrobial Activity
- Gestational Diabetes Research and Management
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Lipid Membrane Structure and Behavior
- Drug Transport and Resistance Mechanisms
- Edible Oils Quality and Analysis
- Antioxidant Activity and Oxidative Stress
- Glaucoma and retinal disorders
- Plant biochemistry and biosynthesis
- Retinal Diseases and Treatments
- Cannabis and Cannabinoid Research
- Helicobacter pylori-related gastroenterology studies
- Mitochondrial Function and Pathology
Hospital Universitario Virgen del Rocío
2006-2025
Consejo Superior de Investigaciones Científicas
2020-2025
Instituto de Biomedicina de Sevilla
2015-2025
Universidad de Sevilla
2016-2025
S:t Eriks Ögonsjukhus
2023-2025
Karolinska Institutet
2023-2025
Hospital Universitario Fundación Alcorcón
2012-2018
St. Thomas University
2016
Hospital Universitario Nuestra Señora de Candelaria
2008-2014
Czech Academy of Sciences, Institute of Physiology
2011
Captopril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the treatment of arterial hypertension and cardiovascular diseases. Our objective was to study whether captopril able attenuate cardiac inflammatory process associated with hypertension.Left ventricle mRNA expression plasma levels pro-inflammatory (interleukin-1beta (IL-1beta) IL-6) anti-inflammatory (IL-10) cytokines, were measured spontaneously hypertensive rats (SHR) their control normotensive, Wistar-Kyoto (WKY)...
Because of their low levels expression and the inadequacy current research tools, CB2 cannabinoid receptors (CB2R) have been difficult to study, particularly in brain. This receptor is especially relevant context neuroinflammation, so novel tools are needed unveil its pathophysiological role(s). We generated a transgenic mouse model which enhanced green fluorescent protein (EGFP) under control cnr2 gene promoter through insertion an Internal Ribosomal Entry Site followed by EGFP coding...
Volatile compounds were isolated from strawberry guava fruit by simultaneous steam distillation−solvent extraction according to Likens−Nickerson. Compounds identified capillary GC-MS and sensorially characterized sniffing GC. Two hundred four in the aroma concentrate, of which ethanol, α-pinene, (Z)-3-hexenol, (E)-β-caryophyllene, hexadecanoic acid found be major constituents. The presence many aliphatic esters terpenic is thought contribute unique flavor fruit. Keywords: Volatiles; guava; esters;
The mechanism(s) underlying the effects of L-carnitine (beta-hydroxy-gamma-N-trimethylammonium-butyrate; LC) in cardiovascular diseases are not well clarified. Previous studies have demonstrated that oxidative stress and inflammation contribute to arterial hypertension, antioxidant and/or anti-inflammatory therapies been proposed. We hypothesized LC might attenuate hypertensive status through an inhibition process.Heart mRNA expression plasma levels inflammatory markers, interleukin-1 beta...
The endocannabinoid system may regulate glial cell functions and their responses to pathological stimuli, specifically, Alzheimer's disease. One experimental approach is the enhancement of tone by blocking activity degradative enzymes, such as fatty acid amide hydrolase (FAAH).We examined role FAAH in response astrocytes pathologic form β-amyloid (Aβ). Astrocytes from wild-type mice (WT) lacking (FAAH-KO) were incubated with Aβ for 8, 24 48 h, inflammatory quantified elisa, western-blotting...
Abstract Arterial hypertension leads to oxidative and inflammatory imbalances, triggering hypertensive organ damage through several pathways. We have previously described the antioxidant anti‐inflammatory properties of olive oil extracted from wild tree ( Olea europaea var. sylvestris , acebuche, ACE) against ocular damage. The aim this study was clarify molecular mechanisms involved in beneficial effect ACE on eyes, focusing nitric oxide (NO)/arginine metabolism. To end, we used retinal...
The effects of two oleic-acid-rich diets (containing olive oil, OO, and high-oleic-acid sunflower HOSO) on plasma liver lipid composition detoxification enzyme activities, were compared with those a fish-oil (FO) diet control diet. Compared the diet, hepatic total triacylglycerol concentrations increased in animals fed HOSO OO decreased FO showed highest level cholesterol had lower when diets. In comparison enriched oleic acid, group higher levels polyunsaturated fatty acids n-3 series n-6...
The development of renal fibrosis is a consequence arterial hypertension. L-carnitine plays an essential role in the β-oxidation fatty acids, and we have previously demonstrated hypotensive, antioxidant, anti-inflammatory effects This work aims to analyze effect on explore participation peroxisome-proliferator activated receptor (PPAR)-γ this effect.Four groups or rats were used: control, treated with L-carnitine, L-NAME, + L-NAME. Cultured rat kidney cells also used examine PPAR-γ effect.An...
Leptin is a protein involved in the regulation of food intake and immune inflammatory responses, among other functions. Evidences demonstrate that obesity directly associated with high levels leptin, suggesting leptin may link elevated cardiovascular renal risk increased body weight. Adverse effects include oxidative stress mediated by activation NADPH oxidase. The aim this study was to evaluate effect L-carnitine (LC) rat epithelial cells (NRK-52E) exposed order generate state...