A5033390943- Cholesterol and Lipid Metabolism
- Antioxidant Activity and Oxidative Stress
- Lipoproteins and Cardiovascular Health
- Nitric Oxide and Endothelin Effects
- Pharmaceutical Practices and Patient Outcomes
- Metabolism and Genetic Disorders
- Fatty Acid Research and Health
- Edible Oils Quality and Analysis
- Medication Adherence and Compliance
- Higher Education Teaching and Evaluation
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Cardiovascular Health and Disease Prevention
- Vitamin K Research Studies
- Eicosanoids and Hypertension Pharmacology
- Atherosclerosis and Cardiovascular Diseases
- Metabolomics and Mass Spectrometry Studies
- Phytochemicals and Antioxidant Activities
- HIV-related health complications and treatments
- Health and Medical Education
- Cardiovascular Disease and Adiposity
- Receptor Mechanisms and Signaling
- Sexual function and dysfunction studies
- Marine Biology and Environmental Chemistry
- Systemic Lupus Erythematosus Research
Universidad de Sevilla
2014-2024
University of Veterinary Medicine in Košice
2022
University of Malta
2022
University of Montana
2022
De Montfort University
2022
University of Bergen
2022
Kaunas kolegija Higher Education Institution
2022
Hospital Universitario de Valme
2019
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2005-2017
Universidade da Coruña
1999-2005
Endothelial dysfunction has been described with ageing but the mechanisms responsible have not clearly elucidated and might be different from one vessel to other. This study assesses relative contribution of endothelial nitric oxide (NO) cyclo‐oxygenase (COX) metabolites in relaxation acetylcholine aorta small mesenteric artery rat. In branch II or III superior (SMA), endothelium‐dependent was between 12–14 (adult) 32‐week‐old rats whereas it reduced at 70–100 (old) weeks age. Despite an...
Background Hydroxymethylglutaryl coenzyme A (HMGCoA) reductase inhibitors have beneficial effects beyond their cholesterol-lowering properties. The antioxidant mechanism of HMGCoA is not completely understood. Objectives To elucidate the effect simvastatin. Methods We studied influence simvastatin treatment on development hypertension, modification systems, and reactivity aortic rings in Wistar–Kyoto (WKY) spontaneously hypertensive (SHR) rats. Results Simvastatin had no blood pressure (BP)....
Traditionally hand-pressed argan oil, obtained from Argania spinosa seeds, is eaten raw in south-west Morocco; its rich composition of tocopherols, MUFA and PUFA make a study actions on risk factors for CVD, such as hypertension, interesting. The effects 7 weeks treatment with oil (10ml/kg) the blood pressure endothelial function spontaneously hypertensive rats (SHR) normotensive Wistar–Kyoto were investigated. Systolic heart rate measured every week by tail-cuff method was assessed...
Pomace olive oil, an oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions pomace potential effects isolated on metabolic complications obesity, this study investigates for first time dietary intervention with high concentrations triterpenic acids (POCTA), acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to POCTA-diet 10 weeks, show substantial reduction...
1. Vascular effects of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, simvastatin, were studied in conductance (aorta) and resistance vessels (branch II or III superior mesenteric artery, SMA) rat (12 - 14 weeks old). 2. Simvastatin produced relaxation both aorta SMA, with without functional endothelium. These responses inhibited by product HMG-CoA reductase, mevalonate (1 mmol l(-1)). 3. In endothelium, NO-synthase L-N(G)-nitroarginine (L-NOARG, 30 micromol l(-1)),...
The effects of oral administration the HMG-CoA reductase inhibitor, simvastatin (SV), on age-related endothelial dysfunction were investigated in aorta male Wistar rats. Adult (12-14 weeks) and old (60-80 rats treated daily for 12 weeks with either vehicle or SV (1 mg kg(-1)). In rats, treatment did not significantly affect systolic blood pressure LDL-cholesterol, but it reduced plasma cholesterol, triglycerides oxidised LDL though total antioxidant status. improved endothelium-dependent...
Aims Obesity is a primary contributor to acquired insulin resistance leading the development of type 2 diabetes and cardiovascular alterations. The carnitine derivate, propionyl-L-carnitine (PLC), plays key role in energy control. Our aim was evaluate metabolic effects PLC diet-induced obese mice. Methods C57BL/6 mice were fed high-fat diet for 9 weeks then divided into two groups, receiving either free- (vehicle-HF) or PLC-supplemented water (200 mg/kg/day) during 4 additional weeks....
Microcystins (MCs), hepatotoxins from cyanobacteria, induce oxidative stress and pathological changes in fish that can be ameliorated with chemoprotectants such as vitamin E (vit E). This study investigated the time period after MCs exposure which Trolox, a analog, is effective against histological damage different organs of tilapia (Oreochromis niloticus). Fish were fed Trolox supplement (700 mg/kg diet) for 7 days, or received only commercial food, then exposed to single oral dose 120...
Pomace olive oil (POM), an subproduct traditionally used in Spain, is a good source of minor components from the unsaponifiable fraction such as triterpenoids, mainly form oleanolic acid, which induces vascular protection and vasodilatation. Our aim was to evaluate effects long-term intake diets enriched POM with high concentration acid on endothelial dysfunction associated hypertension small mesenteric arteries (SMA) spontaneously hypertensive rats (SHR). During 12 weeks, (six per group)...
Rice bran is an exceptional source of such antioxidant molecules as γ-oryzanol and ferulic acid, but their bioavailability metabolism within this matrix remain unknown.
The effect of treatment with either 200 mg x kg(-1) L-carnitine (LC) or propionyl-L-carnitine (PLC) was studied on endothelial dysfunction small mesenteric arteries (SMA) from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats.Systolic blood pressure (SBP) measured vascular functions were assessed by the carbachol (CCh) phenylephrine (Phe). O2- produced SMA eNOS expression evaluated chemiluminescence Western blot, respectively.Although SBP not affected, relaxation...
To clarify the mechanism underlying antioxidant properties of l-carnitine (LC) and propionyl-l-carnitine (PLC) on spontaneously hypertensive (SHR) normotensive WKY, animals were treated with either PLC or LC (200 mg kg− 1). Aorta was dissected contraction to (R)-( − )-phenylephrine (Phe) relaxation carbachol (CCh) assessed in presence not NO synthase (NOS) inhibitor, l-NAME. production evaluated by lucigenin-enhanced chemiluminescence its participation observed after incubation superoxide...