A5072127652- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Pharmacology and Obesity Treatment
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Fibroblast Growth Factor Research
- Obstructive Sleep Apnea Research
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Cardiovascular Health and Disease Prevention
- Bariatric Surgery and Outcomes
- Extracellular vesicles in disease
- Nuclear Structure and Function
- Cerebrovascular and Carotid Artery Diseases
- Obesity, Physical Activity, Diet
Centre Hospitalier Universitaire de Tours
2015-2024
Physiologie de la Reproduction et des Comportements
2019-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
Université de Tours
2015-2024
Centre National de la Recherche Scientifique
2019-2023
Hôpital Bretonneau
2023
RELX Group (United States)
2023
Unité de Nutrition Humaine
2023
Biologie des Oiseaux et Aviculture
2023
Inserm
2005-2018
Background: Maternally inherited diabetes and deafness (MIDD), which is seen in 0.5% to 2.8% of patients with type 2 mellitus, related a point mutation at position 3243 mitochondrial (mt) DNA. Its clinical description incomplete. Objective: To study the presentation complications MIDD identify characteristics that may help select diabetic for mtDNA screening. Design: Multicenter prospective descriptive study. Setting: 16 French departments internal medicine, metabolic diseases, or both....
Defective regulation of gene expression may be involved in the pathogenesis type 2 diabetes. We have characterized concerted by insulin (3-h hyperinsulinemic clamp) 10 genes related to action skeletal muscle and subcutaneous adipose tissue, we verified whether a defective some them could specifically encountered tissues diabetic patients. Basal mRNA levels (determined reverse transcriptase–competitive polymerase chain reaction) receptor, receptor substrate-1, p85α phosphatidylinositol...
The clinical expression of maturity-onset diabetes the young (MODY)-3 is highly variable. This may be due to environmental and/or genetic factors, including molecular characteristics hepatocyte nuclear factor 1-alpha (HNF1A) gene mutation.We analyzed mutations identified in 356 unrelated MODY3 patients, 118 novel mutations, and searched for correlations between genotype age at diagnosis diabetes.Missense prevailed dimerization DNA-binding domains (74%), while truncating were predominant...
The pathophysiological mechanisms to explain the association between risk of type 2 diabetes and elevated concentrations γ-glutamyltransferase (GGT) alanineaminotransferase (ALT) remain poorly characterized. We explored liver enzymes with peripheral hepatic insulin resistance, secretion, clearance, glucagon concentration.We studied 1,309 nondiabetic individuals from Relationship Insulin Sensitivity Cardiovascular disease (RISC) study; all had a euglycemic-hyperinsulinemic clamp an oral...
Fasting-based index estimates of insulin sensitivity were compared with euglycemic hyperinsulinemic clamp (IS clamp) measurements in 148 subjects: normal controls (n = 46), and obese 12), polycystic ovary syndrome 16), first-degree relatives type 2 diabetic 17), impaired glucose tolerance 28), 29) patients. The fasting-based indexes tested included log homeostasis model assessment (HOMA), the quantitative check (QUICKI), revised QUICKI, a new QUICKI using fasting plasma glycerol. In...
Mutations in the LMNA gene are responsible for several laminopathies, including lipodystrophies, with complex genotype/phenotype relationships. OBJECTIVE, DESIGN, SETTING, AND PATIENTS: Sequencing of coding regions 277 unrelated adults investigated lipodystrophy and/or insulin resistance revealed 17 patients substitutions at codon 482 observed typical Dunnigan's familial partial and 10 other mutations. We report here phenotypes non-codon mutations compare them those 11 also studied skin...
Polycystic ovary syndrome (PCOS), the main androgen disorder in women, has been suggested to be associated with a high risk of developing cardiovascular disease and type 2 diabetes. In many PCOS patients, overweight or central obesity is generally increases fasting insulin levels, resistance, glucose intolerance, identified as target for new therapeutic strategy, including early change lifestyle. Early biochemical marker(s) identifying at-risk patients will useful prevention studies. The...
The structure and function of blood vessels varies along the vascular tree. Endothelial dysfunction is a hallmark increased cardiovascular (CV) risk that can be assessed by several methods, some which are invasive restricted application. aim this study was to determine whether laser Doppler response skin microcirculation acetylcholine, reflects conduit artery brachial flow-mediated dilation (FMD).Noninvasive measurement endothelium-dependent vasodilation in flowmetry (LDF) local transdermal...
Context: Maternally inherited diabetes and deafness (MIDD) is a rare form of with matrilineal transmission, sensorineural hearing loss, macular pattern dystrophy due to an A G transition at position 3243 mitochondrial DNA (mtDNA) (m.3243A>G). The phenotypic heterogeneity MIDD may be the consequence different levels mutated mtDNA among mitochondria in given tissue. Objective: aim present study was thus ascertain correlation between severity phenotype patients level heteroplasmy blood...
In men, obesity and the metabolic syndrome are accompanied by decreased testosterone levels, but little is known about associations between visceral adipose tissue (VAT), VAT-related inflammation sex steroids.To examine relative impact of VAT, abdominal subcutaneous (SAT) interleukin 6 (IL-6), a marker VAT-induced inflammation, on (T) 17β-oestradiol (E2) levels in dysmetabolic men.We study NUMEVOX cohort 229 aged 27-77 years, who all had at least one criterion (on average three). IL-6,...
Some mutations in LMNA, encoding A-type lamins, are responsible for Dunnigan-type-familial partial lipodystrophy (FPLD2), with altered fat distribution and metabolism. The high prevalence of early severe cardiovascular outcomes these patients suggests that, addition to metabolic risk factors, FPLD2-associated LMNA could have a direct role on the vascular wall cells.We analyzed phenotype 19 FPLD2 aged >30 years p.R482 heterozygous substitutions, effects p.R482W-prelamin-A overexpression human...
Recent evidence supporting that adipose tissue (AT)-derived extracellular vesicles (EVs) carry an important part of the AT secretome led us to characterize EV-adipokine profile. In addition evidencing a high AT-derived EV secretion ability is further increased by obesity, we identify enrichment oligomeric forms adiponectin in small EVs (sEVs). This adipokine mainly distributed at external surface as result nonspecific adsorption soluble adiponectin. also constitute stable conveyors blood...
Background: The "food addiction" phenotype identifies a subpopulation of individuals experiencing substance-dependence symptoms toward specific foods. In the current debate on whether should be considered as an addictive disorder, assessment personality traits associated with this would provide arguments for or against and its inclusion in "substance-related disorder" category. Objectives: To assess characteristics obesity surgery candidates (i.e., big five dimensions, alexithymia...
Microparticles are membrane vesicles with pro-inflammatory properties. Circulating levels of microparticles have previously been found to be elevated in patients metabolic syndrome (MetS). The present study aimed evaluate the effects vivo treatment microparticles, from MetS and healthy subjects (HS), on ex vascular function mice. isolated or HS, a vehicle were intravenously injected into mice, following which reactivity response vasoconstrictor agonists was assessed by myography respect...
Objective : Adiponutrin is a new transmembrane protein specifically expressed in adipose tissue. In obese subjects, short- or long-term calorie restriction diets were associated with reduction adiponutrin gene expression. Adiponut.rin mRNA level was previously shown to be negatively correlated fasting glucose plasma levels and insulin sensitivity of non-diabetic non-obese subjects. The purpose the present work get more insight into regulation expression by and/or using clamp studies examine...
Polycyclic aromatic hydrocarbons (PAHs) are one of the most prevalent classes environmental pollutants. Some evidence shows that PAHs could be involved in human obesity. However, little is known about distribution patterns adipose tissue (AT) and role on adipogenesis/lipogenesis. The aims this pilot study were to determine concentrations 16 defined as high-priority pollutants plasma French Polish bariatric patients, well their correlation with body mass index (BMI), AT adipokines expression...