A5004520998- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Advanced Glycation End Products research
- Edible Oils Quality and Analysis
- Insect and Pesticide Research
- Alcohol Consumption and Health Effects
- Zebrafish Biomedical Research Applications
- Mycotoxins in Agriculture and Food
- Sesame and Sesamin Research
- Adipose Tissue and Metabolism
- Pluripotent Stem Cells Research
- Atherosclerosis and Cardiovascular Diseases
- Natural product bioactivities and synthesis
- Marine Toxins and Detection Methods
- CRISPR and Genetic Engineering
- Nicotinic Acetylcholine Receptors Study
- Genetics, Aging, and Longevity in Model Organisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological Disease Mechanisms and Treatments
- Coenzyme Q10 studies and effects
- Animal testing and alternatives
- Natural Antidiabetic Agents Studies
University of Urbino
2005-2018
Brigham and Women's Hospital
2013-2014
Woman's Hospital
2014
Harvard University
2014
Universidad de Sevilla
2012-2013
Neuroinflammation is an important contributor to pathogenesis of age-related neurodegenerative disorders such as Alzheimer's or Parkinson's disease. Accumulating evidence indicates that inhibition microglia-mediated neuroinflammation may become a reliable protective strategy for processes. Flavonoids, widely distributed in the vegetable kingdom and foods honey, have been suggested novel therapeutic agents reduction deleterious effects neuroinflammation. The present study investigated...
Journal of Unexplored Medical Data is an open access journal, which considers well-conducted medical science studies, including clinical trials, pilot research reports, original articles, reviews and short communications in the field science.
Candida albicans is a pathogenic yeast, which forms range of polarized and expanded cell shapes. We aimed to determine the correlation between honey extract (HFE) activity changes in C. cycle, morphology subcellular organelles.HFE anticandidal properties were investigated using flow cytometry scanning electron microscopy.Flow microscopy analyses indicated that HFE may inhibit growth three phenotypes displayed by reduce infection affecting membrane integrity. affects hyphal transition...
Candida albicans is the most prevalent fungal pathogen in humans. In this study, flavonoids from unprocessed multifloral honey were extracted and investigated their anticandidal activity vitro. These results indicated that inhibited growth; however, they did not kill yeasts directly affect cytoplasmic membrane. The viability tests of cells yeast with fluorescent probe Sybr green I combination propidium iodide suggested antifungal depended on relative lipophilic properties may reach a...
Neosaxitoxin (NeoSTX) is a specific reversible blocker of voltage gated sodium channels on excitable cells. In the last decade, it has been tested in number interesting clinical trials, however there still little information available mammalian toxicity. Rats were treated for 12 weeks with doses 1, 3 or 6 μg/kg subcutaneous NeoSTX. At and 17, animals sacrificed blood samples collected hematological biochemical analysis. Organs harvested weight determination histopathological assessments. The...
Embryonic and larval Danio rerio is increasingly used as a toxicological model to conduct rapid in vivo tests developmental toxicity assays; the zebrafish features high genetic homology mammals; robust phenotypes; its value high-throughput chemical screening have made it powerful tool evaluate toxicity. New methodologies of genome editing CRISPR/Cas9; ZFN or Talen make suitable perform studies pair human diseases well. This review surveys recent studies; employing experimental model;...
Hydroxytyrosol (HT) is released primarily in olive mill wastewater and oil (Fabiani et al., 2008). In animal cellular model studies, HT its metabolites show strong antioxidant antimicrobial properties, as well beneficial effects on the cardio-vascular system several human diseases (Goya 2007). Differently, many reports tumor cells (Han 2009) suggested that down-regulates cell viability proliferation, induces apoptosis. Nevertheless, little known about effect normal Previous biochemical...
Telomere length shortens with age and predicts the onset of cellular senescence organ aging progressive deterioration function. It remains, however, to be documented whether loss telomeric DNA in cardiac stem cells (CSCs) myocytes is causally involved manifestations cardiomyopathy. To test this possibility, third generation mice carrying a deletion RNA component telomerase (Terc -/- mice) was studied early life at 3-12 months age. Wild type (WT) senescent 30 were included analysis establish...