A5073839439- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Galectins and Cancer Biology
- Inflammation biomarkers and pathways
- Nuclear Receptors and Signaling
- Advanced Glycation End Products research
- Neurological Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Diet and metabolism studies
- Biochemical effects in animals
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Macrophage Migration Inhibitory Factor
- Adipose Tissue and Metabolism
- Autism Spectrum Disorder Research
- Gastrointestinal motility and disorders
- Neurological diseases and metabolism
- CRISPR and Genetic Engineering
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
Instituto de Biomedicina de Sevilla
2014-2024
Universidad de Sevilla
2014-2024
Hospital Universitario Virgen del Rocío
2014-2024
Unité de Recherche Œnologie
2020
Molécules d'Intérêt Biologique
2020
Université de Bordeaux
2020
Christie's
2020
Consejo Superior de Investigaciones Científicas
2015-2019
Unidades Centrales Científico-Técnicas
2019
Abstract Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads brain through vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) humans can progress with emergence of pathogenic α‐synuclein (α‐syn) gastrointestinal tract midbrain dopaminergic neurons. Methods We have analysed gut ventral from subjects previously diagnosed IBD form a DSS‐based rat model inflammation terms...
Peripheral inflammation could play a role in the origin and development of certain neurodegenerative disorders. To ascertain this possibility, model dopaminergic neurodegeneration based on injection inflammatory agent lipopolysaccharide (LPS) within substantia nigra was assayed rats with ulcerative colitis (UC) induced by ingestion dextran sulphate sodium. We found an increase levels markers from serum (tumor necrosis factor-α, IL-1β, IL-6 acute phase protein C-reactive protein) IL-6,...
Parkinson’s disease is an irreversible neurodegenerative linked to progressive movement disorders and accompanied by inflammatory reaction that believed contribute its pathogenesis. Since sensitivity inflammation not the same in all brain structures, aim of this work was test whether physiological conditions as stress could enhance susceptibility substantia nigra, where death dopaminergic neurons takes place disease. To achieve our aim, we induced process nonstressed stressed rats (subject a...
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite central role for microglia neuroinflammation and neurodegeneration, little is known about their epigenomic regulation response. Here, we show that Ten-eleven translocation 2 (TET2) methylcytosine dioxygenase expression increased upon stimulation with various inflammogens through a NF-κB-dependent pathway. We found TET2 regulates early gene transcriptional changes, leading to metabolic...
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect on substantia nigra (SN), main structure affected in Parkinson's disease (PD), has not yet been studied depth. Inflammation a key feature PD and it may play central role neurodegeneration that takes place this disorder. aim work was determine microglial SN rats using animal model...
Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important the progression of pathogenesis, or even a triggering factor. Here we review that peripheral inflammation enhances degeneration nigrostriatal dopaminergic system induced by different insults; inflammations have been used, such as IL-1β ulcerative colitis model, well insults 6-hydroxydopamine lipopolysaccharide. In all cases, an increased loss neurons was described; substantia nigra...
Neuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson's disease (PD), and seems to play key role in their development progression. Microglia cells, the principal orchestrators of neuroinflammation, can be polarized different phenotypes, which means they are able have anti-inflammatory, pro-inflammatory, or effects. Increasing evidence supports that traditional Mediterranean dietary pattern related reduction cognitive decline diseases. A considerable...
We have developed an animal model of degeneration the nigrostriatal dopaminergic neurons, neuronal system involved in Parkinson's disease (PD). The implication neuroinflammation on this was originally established 1988, when presence activated microglia substantia nigra (SN) parkinsonians reported by McGeer et al. Neuroinflammation could be progression or even has more direct implications. injected 2 μg potent proinflammatory compound lipopolysaccharide (LPS) different areas CNS, finding that...
Adult hippocampal neurogenesis (AHN) is a process involved in numerous neurodegenerative diseases. Many researchers have described microglia as key component regulating the formation and migration of new neurons along rostral migratory stream. Caspase-3 cysteine-aspartate-protease classically considered one main effector caspases cell death program process. In addition to this classical function, we identified role protein modulator microglial function; however, its action on neurogenic...
Abstract Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children young adults in which the principal driver a fusion gene, EWSR1-FLI1 . Although essential role protein regulation oncogenesis, survival, progression processes has been described in-depth, little known about chimeric fusion-gene expression. Here, we demonstrate that active nuclear HDAC6 EWS modulates acetylation status specificity 1 (SP1), consequently regulating SP1/P300 activator complex binding to EWSR1...