A5092179681- Inflammation biomarkers and pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
Universidad de Sevilla
2023
Hospital Universitario Virgen del Rocío
2023
Instituto de Biomedicina de Sevilla
2023
Galectin-3 (Gal3) is a regulator of microglial activation implicated in Alzheimer's disease (AD). However, Gal3 role modulating phenotype towards amyloid-beta (Aβ) remains poorly understood. We demonstrate that affects several functions and binds Aβ fibrils with high affinity, stabilizing aggregation intermediates alter fibril kinetics morphology. Furthermore, deletion the direct relationship between microglia Aβ, reducing its uptake increasing compaction. AlphaFold modeling predicts...
Adult hippocampal neurogenesis (AHN) is a process involved in numerous neurodegenerative diseases. Many researchers have described microglia as key component regulating the formation and migration of new neurons along rostral migratory stream. Caspase-3 cysteine-aspartate-protease classically considered one main effector caspases cell death program process. In addition to this classical function, we identified role protein modulator microglial function; however, its action on neurogenic...