A5028682409- Cell Adhesion Molecules Research
- RNA modifications and cancer
- Folate and B Vitamins Research
- Bacterial Genetics and Biotechnology
- Metabolism and Genetic Disorders
- Biochemical and Structural Characterization
- Caveolin-1 and cellular processes
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
- S100 Proteins and Annexins
- Protein Structure and Dynamics
- Porphyrin Metabolism and Disorders
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- Marine Biology and Environmental Chemistry
- Cellular Mechanics and Interactions
- Hippo pathway signaling and YAP/TAZ
- Signaling Pathways in Disease
- Antimicrobial Peptides and Activities
- Protist diversity and phylogeny
- Bacteriophages and microbial interactions
- Proteoglycans and glycosaminoglycans research
Lund University
2023
Umeå University
2023
Okinawa Institute of Science and Technology Graduate University
2018-2021
Åbo Akademi University
2011-2014
University of Turku
2011
Toxin-antitoxin (TA) systems are a large group of small genetic modules found in prokaryotes and their mobile elements. Type II TAs encoded as bicistronic (two-gene) operons that encode two proteins: toxin neutralizing antitoxin. Using our tool NetFlax (standing for Network-FlaGs toxins antitoxins), we have performed large-scale bioinformatic analysis proteinaceous TAs, revealing interconnected clusters constituting core network TA-like gene pairs. To understand the structural basis...
Galectin-3 (Gal3) is a regulator of microglial activation implicated in Alzheimer's disease (AD). However, Gal3 role modulating phenotype towards amyloid-beta (Aβ) remains poorly understood. We demonstrate that affects several functions and binds Aβ fibrils with high affinity, stabilizing aggregation intermediates alter fibril kinetics morphology. Furthermore, deletion the direct relationship between microglia Aβ, reducing its uptake increasing compaction. AlphaFold modeling predicts...
Methyltransferases (MTases) are superfamilies of enzymes that catalyze the transfer a methyl group from S-adenosylmethionine (SAM), nucleoside-based cofactor, to wide variety substrates such as DNA, RNA, proteins, small molecules, and lipids. Depending upon their structural features, MTases can be further classified into different classes; we consider exclusively largest class MTases, Rossmann-fold MTases. It has been shown nucleoside cofactor-binding Rossmann enzymes, particularly...
Integrins are heterodimeric cell-surface receptors with key functions in cell-cell and cell-matrix adhesion. Integrin α β subunits present throughout the metazoans, but it is unclear whether predate origin of multicellular organisms. Several component domains have been detected bacteria, one which, a specific 7-bladed β-propeller domain, unique feature integrin subunits. Here, we describe structure-derived motif, which incorporates features each blade from X-ray structures human αIIbβ3 αVβ3,...
Toxin-antitoxin (TA) systems are a large group of small genetic modules found in prokaryotes and their mobile elements. Type II TAs encoded as bicistronic (two-gene) operons that encode two proteins: toxin neutralising antitoxin. Using our tool NetFlax (standing for Network-FlaGs toxins antitoxins) we have performed large-scale bioinformatic analysis proteinaceous TAs, revealing interconnected clusters constituting core network TA-like gene pairs. To understand the structural basis...
Half of the 18 human integrins α subunits have an inserted αI domain yet none been observed in species that diverged prior to appearance urochordates (ascidians). The urochordate integrin domains are not orthologues but paralogues, extend throughout later-diverging vertebrates and bony fish with duplicate isoforms. Here, we report evidence for agnathostomes (jawless vertebrates) later diverging species. Sequence comparisons, phylogenetic analyses molecular modeling show one nearly...
Methionine adenosyltransferase (MAT) catalyzes the biosynthesis of S-adenosyl methionine from l-methionine and ATP. MAT enzymes are ancient, believed to share a common ancestor, highly conserved in all three domains life. However, sequences archaeal MATs show considerable divergence compared with their bacterial eukaryotic counterparts. Furthermore, structural significance functional this sequence not well understood. In present study, we employed analysis ancestral reconstruction...
Abstract Methionine adenosyltransferase (MAT), which catalyzes the biosynthesis of S-adenosylmethionine from L-methionine and ATP, is an ancient, highly conserved enzyme present in all three domains life. Although MAT enzymes each domain are believed to share a common ancestor, sequences archaeal MATs show high degree divergence bacterial eukaryotic MATs. However, structural functional consequences this sequence not well understood. Here, we use bioinformatics analysis ancestral...