A5074362841- Neuroinflammation and Neurodegeneration Mechanisms
- Galectins and Cancer Biology
- Parkinson's Disease Mechanisms and Treatments
- Inflammation biomarkers and pathways
- Nuclear Receptors and Signaling
- Signaling Pathways in Disease
- Circular RNAs in diseases
- Autism Spectrum Disorder Research
- Diet and metabolism studies
- CRISPR and Genetic Engineering
- Gastrointestinal motility and disorders
- Olfactory and Sensory Function Studies
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Lysosomal Storage Disorders Research
- Immune cells in cancer
- Prion Diseases and Protein Misfolding
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Apelin-related biomedical research
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Macrophage Migration Inhibitory Factor
Lund University
2022-2025
Instituto de Biomedicina de Sevilla
2018-2024
Universidad de Sevilla
2018-2024
Hospital Universitario Virgen del Rocío
2018-2024
Consejo Superior de Investigaciones Científicas
2015
Alzheimer's disease (AD) is a progressive neurodegenerative in which the formation of extracellular aggregates amyloid beta (Aβ) peptide, fibrillary tangles intraneuronal tau and microglial activation are major pathological hallmarks. One key molecules involved galectin-3 (gal3), we demonstrate here for first time role gal3 AD pathology. Gal3 was highly upregulated brains patients 5xFAD (familial disease) mice found specifically expressed microglia associated with Aβ plaques....
Abstract Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads brain through vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) humans can progress with emergence of pathogenic α‐synuclein (α‐syn) gastrointestinal tract midbrain dopaminergic neurons. Methods We have analysed gut ventral from subjects previously diagnosed IBD form a DSS‐based rat model inflammation terms...
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role peripheral induced by lipopolysaccharide (LPS) administration MPTP-based model Parkinson's disease. Brain inflammation, microglia and astroglia activation, disruption blood-brain barrier (BBB) integrity nigrostriatal system were evaluated response to i.p. injection LPS, MPTP or combination both. Our results showed that combinative treatment exacerbates activation enhances...
COVID19 disease have become so far the most important sanitary crisis in XXI century. In light of events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described regulator both processes. Hereby, we compelling evidences on potential role galectin-3 regulation inflammatory response, fibrosis and infection progression. Moreover,...
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite central role for microglia neuroinflammation and neurodegeneration, little is known about their epigenomic regulation response. Here, we show that Ten-eleven translocation 2 (TET2) methylcytosine dioxygenase expression increased upon stimulation with various inflammogens through a NF-κB-dependent pathway. We found TET2 regulates early gene transcriptional changes, leading to metabolic...
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that efficacy radiotherapy GBM is strikingly potentiated by concomitant therapy with arginine-depleting agent ADI-PEG20 in a non-arginine-auxotrophic cellular background (argininosuccinate synthetase 1 positive). Moreover, this combination led to durable complete radiological pathological response, extended disease-free survival orthotopic immune-competent model GBM, no...
Abstract Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) degeneration of dopaminergic neurons in the substantia nigra (SN). Aggregated α-synuclein (αSYN) known to be main component LB. It has also been reported interact with several proteins organelles. Galectin-3 (GAL3) have detrimental function diseases. galactose-binding protein without catalytic activity expressed mainly activated microglial...
Galectin-3 (Gal-3) is a multifunctional protein that plays pivotal role in the initiation and progression of various central nervous system diseases, including cancer. Although involvement Gal-3 tumour progression, resistance to treatment immunosuppression has long been studied different cancer types, mainly outside system, its elevated expression myeloid glial cells underscores profound impact on brain's immune response. In this context, microglia infiltrating macrophages, predominant...
Galectin-3 (Gal3) is a regulator of microglial activation implicated in Alzheimer's disease (AD). However, Gal3 role modulating phenotype towards amyloid-beta (Aβ) remains poorly understood. We demonstrate that affects several functions and binds Aβ fibrils with high affinity, stabilizing aggregation intermediates alter fibril kinetics morphology. Furthermore, deletion the direct relationship between microglia Aβ, reducing its uptake increasing compaction. AlphaFold modeling predicts...
Experimental Neuroinflammation Laboratory, Department of Medical Science, Lund University, Lund, Sweden (García-Revilla J) Instituto de Biomedicina Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad Seville, Spain J, Venero JL, Rodríguez-Gómez JA) Departamento Bioquímica y Biología Molecular, Facultad Farmacia, Universidad *Correspondence to: Jose Luis Venero, PhD, [email protected]. This is an open access journal, and articles are distributed under the terms Creative...
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an important role in sculpting brain early stages development by eliminating excessive and nonfunctional synapses extra cells. Consequently, impairments this process can underlie many neurological mental illnesses. view is particularly relevant dopamine because it a pleiotropic motor control, motivation, reward processing. study, we analyze effects elimination caspase-8 (CASP8)...
Parkinson’s disease is a highly prevalent neurological disorder for which there currently no cure. Therefore, the knowledge of risk factors as well development new putative molecular targets mandatory. In this sense, peripheral inflammation, especially originated in colon, emerging predisposing factor suffering disease. We have largely studied pleiotropic roles galectin-3 driving microglia-associated immune responses. However, studies aimed at elucidating role inflammation terms microglia...
ABSTRACT According to Braak’s hypothesis, it is plausible that Parkinsońs disease (PD) starts in the enteric nervous system (ENS) spread brain via vagus nerve. Thus, we were wondering whether human inflammatory bowel diseases (IBD) can progress with appearance of pathogenic α-synuclein (α-syn) gastrointestinal tract and midbrain dopaminergic neurons. Analysis sections from IBD patients demonstrated presence phosphorylated α-syn both myenteric (Auerbach’s) submucosal (Meissner’s) plexuses....
Summary Epigenetic mechanisms regulate distinct aspects of the inflammatory response in various immune cell types. Despite central role for microglia, resident macrophages brain, neuroinflammation and neurodegeneration little is known about their epigenetic regulation response. Here, we show that Ten-eleven translocation 2 (TET2) methylcytosine dioxygenase expression increased microglia upon stimulation with inflammogens through a NF-κB-dependent pathway. We found TET2 regulates early gene...