A5054456437- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Prenatal Screening and Diagnostics
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- Pregnancy and preeclampsia studies
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Microtubule and mitosis dynamics
- Renal and related cancers
- Birth, Development, and Health
- Testicular diseases and treatments
- Sarcoma Diagnosis and Treatment
- Circular RNAs in diseases
- Gestational Trophoblastic Disease Studies
- Wnt/β-catenin signaling in development and cancer
- Chromatin Remodeling and Cancer
- COVID-19 and Mental Health
Universidade de São Paulo
2018-2024
Universidade de Ribeirão Preto
2024
Clinics Hospital of Ribeirão Preto
2019-2023
Queen Mary University of London
2019
Fundação Faculdade de Medicina
2019
Pediatrics and Genetics
2018
Universidade Estadual de Maringá
2013
Clínica Santa María
1994
Clinica Santa Maria
1994
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite central role for microglia neuroinflammation and neurodegeneration, little is known about their epigenomic regulation response. Here, we show that Ten-eleven translocation 2 (TET2) methylcytosine dioxygenase expression increased upon stimulation with various inflammogens through a NF-κB-dependent pathway. We found TET2 regulates early gene transcriptional changes, leading to metabolic...
Next-generation sequencing platforms are routinely used for molecular assignment due to their high impact risk stratification and prognosis in medulloblastomas. Yet, low middle-income countries still lack an accurate cost-effective platform perform this allocation. TaqMan Low Density array (TLDA) assay was performed using a set of 20 genes 92 medulloblastoma samples. The same methodology assessed silico microarray data 763 samples from the GSE85217 study, which MB classification by robust...
MUTATIONS OF MITOCHONDRIAL DNA WERE DESCRIBED INTO TWO GENES: The mitochondrially encoded 12S RNA (MT-RNR1) and the tRNA serine(ucn) (MT-TS1). A1555G mutation in MT-RNR1 gene is a frequent cause of deafness different countries.The aim this work was to investigate frequency mitochondrial Brazilians individuals with nonsyndromic deafness, listeners.DNA samples were submitted polymerase chain reaction posterior digestion Hae III enzyme.Seventy eight (78) deaf analyzed; 75 showed normality...
Background and Purpose: Over the last decade, inhibition of PLK1 has proven potent antiproliferative activity in vitro. However, effectiveness most synthetic targeted drugs not yet been translated into clinics. Herein, we investigated vitro effects two second-generation inhibitors BI 6727 GSK461364 breast cancer cell lines as monotherapy or combination with other ionizing radiation. Material Methods: Cell survival was analyzed through XTT®, clonogenicity caspase-3 activation assays were also...
ObjectiveTo investigate the levels of DNA methylation in KvDMR1 (KvLQT1 differentially methylated region 1) embryonic and extra-embryonic tissues.DesignCross-sectional study.SettingUniversity medical center clinical hospital.Patient(s)Embryonic and/or extraembryonic tissues (umbilical cord, chorionic villus, chorion, decidua, amnion) collected from 27 first-trimester pregnancies (up to 12 weeks gestation, single embryos) elective abortions, extravillous trophoblasts (EVTs) top individual...
To assess a panel of cytokines and placental insufficiency with the risk preterm delivery (PTD).
Summary Epigenetic mechanisms regulate distinct aspects of the inflammatory response in various immune cell types. Despite central role for microglia, resident macrophages brain, neuroinflammation and neurodegeneration little is known about their epigenetic regulation response. Here, we show that Ten-eleven translocation 2 (TET2) methylcytosine dioxygenase expression increased microglia upon stimulation with inflammogens through a NF-κB-dependent pathway. We found TET2 regulates early gene...
Câncer é um assunto frequente na mídia e no cotidiano de muitos estudantes, uma vez que ainda representa problema saúde pública com elevado apelo emocional social. A falta do senso crítico processo ensino aprendizagem câncer evidenciada pela defasagem informações conceitos científicos básicos durante a formação escolar. Nesse contexto, o projeto extensão intitulado “A genética dos soldados contra câncer”, teve como objetivo principal compartilhar conhecimentos acadêmicos acerca da gênese,...
TET enzymes are responsible for catalyzing the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), during process active DNA demethylation.These differentially expressed in several tissues development and can regulate conserved signaling pathways, such as Wingless (WNT), Notch, Sonic Hedgehog (SHH) Transforming Growth Factor Beta (TGF-β).Low expression genes consequent reduction 5hmC levels have been commonly reported tumors different origins and, most cases, associated...