A5000554347- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Neuroblastoma Research and Treatments
- Brain Metastases and Treatment
- Ferroptosis and cancer prognosis
- Sarcoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cell death mechanisms and regulation
- Childhood Cancer Survivors' Quality of Life
- Ubiquitin and proteasome pathways
- Virology and Viral Diseases
- Thyroid Cancer Diagnosis and Treatment
- Testicular diseases and treatments
- Chromatin Remodeling and Cancer
- Genetic factors in colorectal cancer
- Smart Agriculture and AI
- Cancer Immunotherapy and Biomarkers
Hospital de Câncer de Barretos
2019-2025
Molecular Oncology (United States)
2024
Pontificia Universidad Javeriana
2005-2022
Hospital Clínic de Barcelona
2020
Kaiser Permanente
2020
Universidade de São Paulo
2007-2018
Universidade de Ribeirão Preto
2008-2009
National Council for Scientific and Technological Development
2008
Gonzaga University
2008
Summary Altered expression of histone deacetylases (HDACs) is a common feature in several human malignancies and may represent an interesting target for cancer treatment, including haematological malignancies. We evaluated the mRNA gene profile 12 HDAC genes by quantitative real‐time polymerase chain reaction 94 consecutive childhood acute lymphoblastic leukaemia (ALL) samples its association with clinical/biological features survival. ALL showed higher levels HDAC2, HDAC3, HDAC8, HDAC6...
The present study evaluated the expression profile of 19 genes previously reported in microarray studies and associated with resistance or sensitivity to vincristine (RPLP2, CD44, TCFL5, KCNN1, TRIM24), prednisolone (F8A, CDK2AP1, BLVRB, CD69), daunorubicin (MAP3K12, SHOC2, PCDH9, EGR1, KCNN4) l-asparaginase (GPR56, MAN1A1, CLEC11A, IGFBP7, GATA3). We studied 140 bone marrow samples at diagnosis from children acute lymphoblastic leukemia (ALL) treated according Brazilian Childhood Leukemia...
Background Pediatric adrenocortical tumors (ACT) are rare malignancies and treatment has a small impact on survival in advanced disease the discovery of potential target genes could be important new therapeutic approaches. Methods The mRNA expression levels spindle checkpoint AURKA, AURKB, BUB, BUBR1 were analyzed 60 children with ACT by quantitative real time PCR. anticancer effect ZM447439, an experimental AURK inhibitor, was primary childhood culture carrying TP53 p.R337H mutation....
Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in childhood. Despite advances treatment, about 20% of patients relapse and/or die, indicating need for different therapies this group. Zebularine (ZB) a potent DNA methyltransferase (DNMT) inhibitor and has been associated with gene demethylation enhancement tumor chemosensitivity. This study aimed to evaluate effects ZB, alone or combined chemotherapeutics (methotrexate vincristine), on childhood ALL cell lines....
Introduction Medulloblastoma is the most common and lethal pediatric malignant brain tumor. It comprises four main molecular subgroups: WNT-activated, SHH-activated, Group 3, 4. treatment surgical resection, craniospinal radiation, chemotherapy. However, many patients do not respond to therapy, suffer severe side effects. Cancer immunotherapy targeting immune checkpoints (IC) (PD-1, PD-L1, CTLA4) has been getting disappointing outcomes in tumors. Nevertheless, other less explored may be...
Background Impaired apoptosis has been implicated in the development of childhood adrenocortical tumors (ACT), although expression apoptosis-related gene such not reported. Methods The mRNA levels genes CASP3 , CASP8 CASP9 FAS TNF NFKB and BCL2 were analyzed by quantitative real-time PCR consecutive tumor samples obtained at diagnosis from 60 children with a ACT 11 non-neoplastic adrenal samples. protein was immunohistochemistry. Results A significant association observed between size ≥100 g...
Herein, we present a rare case of nine-month-old boy diagnosed with infant-type hemispheric glioma (gliosarcoma subtype) at the left frontal lobe. Following subtotal resection, patient started chemotherapy BABY POG protocol. We describe clinical diagnosis, histological characteristics, radiological features, molecular aspects, and management this tumor. A comprehensive analysis on tumor tissue showed TPR-NTRK1 gene fusion. The was treated TRK inhibitor, larotrectinib, exhibited stable...
Germ cell tumors (GCTs) constitute diverse neoplasms arising in the gonads or extragonadal locations. Testicular GCTs (TGCTs) are predominant solid adolescents and young men. Despite cisplatin serving as primary therapeutic intervention for TGCTs, 10‑20% of patients with advanced disease demonstrate resistance to cisplatin‑based chemotherapy, epithelial‑mesenchymal transition (EMT) is a potential contributor this resistance. EMT regulated by various factors, including snail family...
Pediatric high-grade glioma (pHGG) is one of the most aggressive brain tumors. Treatment includes surgery, radiotherapy, chemotherapy, or combination therapy in children older than 3−5 years age. These devastating tumors are influenced by hypoxic microenvironment that coordinatively increases expression carbonic anhydrases (CA9 and CA12) involved pH regulation, metabolism, cell invasion, resistance to therapy. The synthetic sulphonamide Indisulam a potent inhibitor CAs. aim this study was...
The aim of this study was to evaluate the expression
Medulloblastoma (MB) is the most prevalent malignant brain tumor in children, known for its heterogeneity and treatment-associated toxicity, there a critical need new therapeutic targets. We analyzed somatic mutation profile of 15 driver genes 69 Latin-Iberian molecularly characterized medulloblastomas using Illumina TruSight Tumor panel. classified variants based on their clinical impact oncogenicity. Among patients, 66.7% were MBSHH, 13.0% MBWNT, 7.3% MBGrp3, MBGrp4. 63 found, 54% as Tier...
Purpose Medulloblastomas are the most common primary malignant brain tumors in children. They divided into molecular subgroups: WNT-activated, SHH-Activated, TP53 mutant or wild type, and non-WNT/non-SHH (Groups 3 4). WNT-activated medulloblastomas usually caused by mutations CTNNB1 gene (85%–90%), remaining cases of type thought to be germline APC . So far, frequencies have been reported mainly North American European populations. The aim this study was report frequency a Latin-Iberian...