A5034297772- Prostate Cancer Treatment and Research
- ATP Synthase and ATPases Research
- Glioma Diagnosis and Treatment
- Redox biology and oxidative stress
- Cancer, Hypoxia, and Metabolism
- Mass Spectrometry Techniques and Applications
Universidade de São Paulo
2022
Universidade Estadual Paulista (Unesp)
2020
Universidade Estadual de Campinas (UNICAMP)
2020
The incidence of prostate cancer (PCa) is increasing, and it currently the second most frequent cause death by in men. Despite advancements therapies, new therapeutic approaches are still needed for treatment-refractory advanced metastatic PCa. Cross-species analysis presents a robust strategy discovery potential targets. This involves integration genomic data from genetically engineered mouse models (GEMMs) human PCa datasets. Considering role antioxidant pathways tumor initiation...
Pediatric high-grade glioma (pHGG) is one of the most aggressive brain tumors. Treatment includes surgery, radiotherapy, chemotherapy, or combination therapy in children older than 3−5 years age. These devastating tumors are influenced by hypoxic microenvironment that coordinatively increases expression carbonic anhydrases (CA9 and CA12) involved pH regulation, metabolism, cell invasion, resistance to therapy. The synthetic sulphonamide Indisulam a potent inhibitor CAs. aim this study was...