A5032995240- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Testicular diseases and treatments
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Hedgehog Signaling Pathway Studies
- Cancer Immunotherapy and Biomarkers
- Neurofibromatosis and Schwannoma Cases
- Neurological Disease Mechanisms and Treatments
- Pituitary Gland Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Ocular Oncology and Treatments
- Adrenal Hormones and Disorders
- Acute Lymphoblastic Leukemia research
- Medicinal Plants and Bioactive Compounds
- Head and Neck Surgical Oncology
- Epilepsy research and treatment
- Herpesvirus Infections and Treatments
- Dysphagia Assessment and Management
- Teratomas and Epidermoid Cysts
Hospital de Câncer de Barretos
2016-2025
Hospital São Paulo
2020
Children Cancer Hospital
2019
PURPOSE BRAF V600 mutation is detected in 5%-10% of pediatric high-grade gliomas (pHGGs), and effective treatments are limited. In previous trials, dabrafenib as monotherapy or combination with trametinib demonstrated activity children adults relapsed/refractory V600–mutant HGG. METHODS This phase II study evaluated plus patients pHGG. The primary objective was overall response rate (ORR) by independent review Response Assessment Neuro-Oncology criteria. Secondary objectives included ORR...
Medulloblastoma is the most frequent malignant brain tumor in children. Four medulloblastoma molecular subgroups, MB SHH , WNT GRP3 and GRP4 have been identified by integrated high‐throughput platforms. Recently, a 22‐gene panel NanoString‐based assay was developed for subgrouping, but robustness of this has not widely evaluated. Mutations gene human telomerase reverse transcriptase (h TERT ) found medulloblastomas are associated with distinct subtypes. This study aimed to implement...
Abstract Introduction Central nervous system (CNS) tumors are the most common solid in childhood, comprising 20% of all neoplasms that age. Besides, they constitute biggest cause morbidity and mortality among childhood tumors, about two thirds surviving patients have sequelae. The build-up sequelae due to neoplastic growth is directly related with time until diagnosis. Therefore, late diagnosis has a negative influence on prognosis. Objective To analyze journey pediatric CNS their families...
Introduction Medulloblastoma is the most common and lethal pediatric malignant brain tumor. It comprises four main molecular subgroups: WNT-activated, SHH-activated, Group 3, 4. treatment surgical resection, craniospinal radiation, chemotherapy. However, many patients do not respond to therapy, suffer severe side effects. Cancer immunotherapy targeting immune checkpoints (IC) (PD-1, PD-L1, CTLA4) has been getting disappointing outcomes in tumors. Nevertheless, other less explored may be...
Herein, we present a rare case of nine-month-old boy diagnosed with infant-type hemispheric glioma (gliosarcoma subtype) at the left frontal lobe. Following subtotal resection, patient started chemotherapy BABY POG protocol. We describe clinical diagnosis, histological characteristics, radiological features, molecular aspects, and management this tumor. A comprehensive analysis on tumor tissue showed TPR-NTRK1 gene fusion. The was treated TRK inhibitor, larotrectinib, exhibited stable...
PURPOSE This prospective Brazilian single-arm trial was conducted to determine response chemotherapy and survival after response-based radiotherapy in children with intracranial germinomas, the setting of a multi-institutional study middle-income country (MIC) significant disparity subspecialty care. PATIENTS AND METHODS Since 2013, 58 patients histologic and/or serum CSF tumor marker evaluations primary germ cell tumors were diagnosed; 43 germinoma HCGβ levels ≤200 mIU/mL five between 100...
Our study aimed to explore real-world treatment scenarios for children and adolescents with neurotrophic tropomyosin receptor kinase (NTRK)-fused tumors, emphasizing access, responses, side effects, outcomes.
Medulloblastoma (MB) is the most prevalent malignant brain tumor in children, known for its heterogeneity and treatment-associated toxicity, there a critical need new therapeutic targets. We analyzed somatic mutation profile of 15 driver genes 69 Latin-Iberian molecularly characterized medulloblastomas using Illumina TruSight Tumor panel. classified variants based on their clinical impact oncogenicity. Among patients, 66.7% were MBSHH, 13.0% MBWNT, 7.3% MBGrp3, MBGrp4. 63 found, 54% as Tier...
Purpose Medulloblastomas are the most common primary malignant brain tumors in children. They divided into molecular subgroups: WNT-activated, SHH-Activated, TP53 mutant or wild type, and non-WNT/non-SHH (Groups 3 4). WNT-activated medulloblastomas usually caused by mutations CTNNB1 gene (85%–90%), remaining cases of type thought to be germline APC . So far, frequencies have been reported mainly North American European populations. The aim this study was report frequency a Latin-Iberian...
The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout ApcMin mice), xenograft models, patient-derived xenografts (PDXs). Our results show progress challenges establishing these need having an appropriate representation population better understand tumor...
Abstract Medulloblastoma is the most frequent malignant brain tumor in children, representing 20% of all childhood tumors. Currently, medulloblastomas are molecularly classified 4 subgroups that associated with distinctive clinicopathological features. KBTBD4 mutations were recently described a subset MBGRP3 and MBGRP4 subgroups. However, no other studies reported medulloblastomas. Thus, our aim was to investigate Brazilian series medulloblastoma. We evaluated 128 medulloblastoma patients...
Choroid plexus tumors (CPTs) are rare intracranial neoplasms, representing <1% of all brain tumors, yet they represent 20% first-year pediatric tumors. Although these have been linked to TP53 germline mutations in the context Li–Fraumeni syndrome, their somatic driver alterations remain poorly understood. In this study, we report two cases lateral ventricle tumors: 3-yr-old male diagnosed with an atypical choroid papilloma (aCPP), and a 6-mo-old female carcinoma (CPC). We performed...
Background Non-germinomatous germ cell tumors (NGGCT) accounts for one third of intracranial GCT. While the germinoma group have an excellent overall survival, standard practice children with NGGCT is still under evaluation. Aims Describe results Brazilian consortium protocol. Methods Since 2013, 15 patients a diagnosis by histopathology and/or serum/cerebrospinal fluid (CSF) tumor markers, βHCG &gt;200mlU/ml positive alpha-fetoprotein were treated neoadjuvant chemotherapy carboplatin,...
Abstract BACKGROUND Primary central nervous system (CNS) germ cell tumors (GCT) are rare tumors, classified according to histological components and tumor markers (TM) as Germinomas Non-Germinomatous Germ Cell Tumors (NGGCT). The aim of this study is assess the outcome patients with Germinoma HCGβ levels between 100-200mIU/ml treated Brazilian CNS GCT Consortium Protocol. METHODS From 2013 2021, forty-three presented and/or TM (serum CSF) consistent diagnosis germinoma, five them...
Abstract BACKGROUND Infant-type hemispheric gliomas (IHG) are epigenetically distinct pediatric high-grade characterized by fusions in receptor tyrosine kinase (RTK) genes. METHODS We performed a methodical literature search, including 30 publications (22 case reports), to identify patients who met the diagnostic criteria of IHG based on 2021 WHO Classification CNS Tumors. Individual patient data were obtained from published and/or via authors publications. Survival analysis was conducted...
Abstract High grade gliomas (HGG) are among the most aggressive brain tumors affecting both adults and children. Adult HGG (aHGG) account for almost 25% of all in adults, with glioblastoma (GBM) being predominant subtype. Pediatric (pHGG), though less common, accounts 3-15% primary children exhibits distinct genetic profiles compared to aHGG. Standard treatment pediatric patients includes maximal surgical resection followed by temozolomide (TMZ)-based chemotherapy radiation therapy. Our...
Abstract High-grade gliomas (HGG) are the most aggressive brain tumors, necessitating robust and representative preclinical models for therapeutic research. We established primary cultures patient-derived xenograft from three pediatric high-grade (pHGG) one adult IDH wild-type glioblastoma (GBM IDHwt) Brazilian patients. The first pHGG case, an 11-year-old with PDGFRA (c.1977C&gt;G) TP53 (c.637C&gt;T) mutations, led to development of HCB570 culture, PDX orthotopic (PDOX) OXP9. second...
Introduction: Central nervous system (CNS) tumors comprise 20% of all childhood cancers, being the second most frequent group tumors.Furthermore, they constitute major cause morbidity and mortality among approximately 60% surviving patients have sequelae due to both neoplastic growth treatment.Therefore, late diagnosis negatively influences prognosis, which is evidenced by inverse relationship between time survival.Objective: To analyze pilgrimage pediatric with CNS reference center.Method:...
Primary central nervous system (CNS) germ cell tumors (GCT) account for 2–3% of brain in children/adolescents Western hemisphere, being classified as germinomas and non-germinomatous GCT (NGGCT). Our objective is to report the results a Brazilian CNSGCT consortium protocol. Since 2013, 28 patients with histologic and/or tumor marker (TM) diagnosis germinoma with/without HCGβ levels ≤200mIU/ml (n=21) NGGCT (n=7), received four/six cycles carboplatin/etoposide/cyclophosphamide, followed by...
Abstract Background: Medulloblastoma is the most frequent malignant brain tumor in children. Currently, four distinct medulloblastoma molecular subgroups have been identified: SHH, WNT, Group 3, and 4. The nCounter® technology (NanoString) a high-throughput platform, highly sensitive, robust useful for analyses of degraded samples, such as formalin-fixed, paraffin-embedded (FFPE) samples. Recently, gene panel 22 genes employing was developed to distinguish meduloblastoma subgroups. Aim: To...