A5062302498- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Management of metastatic bone disease
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Ultrasound and Hyperthermia Applications
- Cancer Genomics and Diagnostics
- Cell death mechanisms and regulation
- Advanced Neuroimaging Techniques and Applications
- Biomedical Text Mining and Ontologies
- Cancer-related cognitive impairment studies
- Chromatin Remodeling and Cancer
- Nanoparticle-Based Drug Delivery
- MRI in cancer diagnosis
- Aortic Disease and Treatment Approaches
- Advanced MRI Techniques and Applications
- Bioinformatics and Genomic Networks
- Vascular Malformations Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Neurological Complications and Syndromes
- Semantic Web and Ontologies
Hospital Israelita Albert Einstein
2014-2025
Universidade Federal de São Paulo
2015-2025
Heidelberg University
2020
Fundação de Apoio à Universidade Federal de São Paulo
2011-2013
Hospital São Paulo
2012
Albert Einstein College of Medicine
2010
Associação Paulista de Medicina
1993-2009
Previous studies have demonstrated remarkable tropism of mesenchymal stem cells (MSCs) toward malignant gliomas, making these a potential vehicle for delivery therapeutic agents to disseminated glioblastoma (GBM) cells. However, the contribution MSCs tumor progression is matter concern. It has been suggested that CD133+ GBM secrete variety chemokines, including monocytes chemoattractant protein-1 (MCP-1/CCL2) and stromal cell-derived factor-1(SDF-1/CXCL12), which could act in this tropism....
// Marcelo Roberto Pereira Freitas 1 , Suzana Maria Fleury Malheiros 2 João Norberto Stávale 3 Thais Priscila Biassi Fernando Tadeu Zamunér Dirlei Ferreira de Souza Begnami 4 Augusto Soares Andre Luíz Vettore Cancer Molecular Biology Laboratory, Department of Science Biology, Federal University São Paulo, Rua Pedro Toledo, SP, Brazil Neurology, Botucatú,São SP – Pathology, Botucatú, A C Camargo Hospital, Prof. Antônio Prudente, Brazil. Correspondence: André L. Vettore, email: Keywords :...
Object. The diagnosis of low-grade glioma (LGG) cannot be based exclusively on conventional magnetic resonance (MR) imaging studies, and target selection for stereotactic biopsy is a crucial issue given the high risk sampling errors. authors hypothesized that perfusion-weighted could provide information microcirculation in presumed supratentorial LGGs. Methods. All adult patients with suspected (nonenhancing) LGGs MR between February 2001 2004 were included this study. Preoperative was...
This investigation analyzed the immunoexpression of FasL, Fas, cleaved caspase-8, and caspase-3 in glioblastomas. Formalin-fixed paraffin-embedded glioblastoma tissues control brain from 97 patients were by tissue microarrays immunohistochemistry. Patients with glioblastomas that negative or weakly stained (<50% cells positive) for caspase-8 had worse cancer-specific overall survival (median = 8.5 months) than did tumors highly expressed 11.7 months; P 0.0325), independent clinical...
Dengue is known to produce a syndrome involving muscles, tendons and joints. The hallmark of this severe myalgia but includes fever, cutaneous rash, headache. neuromuscular aspects infection are outlined only in isolated reports, the muscle histopathological features during have not been described. In order ascertain actual involvement dengue better comprehend histological nature myalgia, we performed clinical neurological evaluation, serum CPK level biopsy (with histochemistry) 15 patients...
Glioblastomas are the most lethal primary brain tumor that frequently relapse or progress as focal masses after radiation, suggesting a fraction of cells responsible for regrowth. The identification cell subpopulation with potent tumorigenic activity supports cancer stem hypothesis in solid tumors. goal this study is to determine methodology establishment human glioblastoma lines. Our aim achieved by taking following approaches: (i) culture; (ii) isolation neurospheres derived from cultures;...
Medulloblastoma is the most frequent malignant brain tumor in children. Four medulloblastoma molecular subgroups, MB SHH , WNT GRP3 and GRP4 have been identified by integrated high‐throughput platforms. Recently, a 22‐gene panel NanoString‐based assay was developed for subgrouping, but robustness of this has not widely evaluated. Mutations gene human telomerase reverse transcriptase (h TERT ) found medulloblastomas are associated with distinct subtypes. This study aimed to implement...
In this study, we aimed to improve patient care for central nervous system conditions based on the 2021 National Institute Health and Care Excellence guidelines. Performance measures were used enhance team accountability address challenges due limited evaluate health insurance variations in clinical staff decision-making. Rehabilitation observed variability surgical costs not measured study. Similar studies also referenced, improvements real-time glioma management suggested. standardizing...
Introduction– The neurological complications of coronary artery surgery with cardiopulmonary bypass (CPB) have been extensively studied, but to our knowledge those without CPB (NCPB) not defined. Patients & methods– We prospectively examined 81 patients, before and up seven days after surgery, compare the morbidity between patients subjected graft (CABG) CPB. analyzed demographic variables, risk factors examination including neuropsychological (NPS) tests using chi-square non-parametric...
GBM may manifest rapidly de novo(primary GBM), or develop slowly from grade II orgrade III astrocytomas (secondary suggesting thatthey are distinct disease entities that evolve throughdifferent genetic pathways.In recent genome-wide analyses, high rates of sponta-neous mutations in the gene encoding cytosolic NADP-dependent isocitrate dehydrogenase 1 (IDH1) have beenreported diffuse gliomas including WHO grades andIII astroglial and oligodendroglial lineages.
Abstract Background Angiogenesis is one of the hallmarks cancer. This complex mechanism tumor progression provides tumors cells with essential nutrients. There have been a limited number investigations markers angiogenesis in Glioblastomas (GBMs), and most previous studies focused on VEGF-A. Recent evidence suggests that there lymphatic system central nervous (CNS), which VEGF-C VEGF–D as interesting biomarker candidates. study was designed to evaluate expressions VEGF-A, −C, −D their...
Objective To evaluate the effect of waiting time (WT) to radiotherapy (RT) on overall survival (OS) glioblastoma (GBM) patients as a reliable prognostic variable in Brazil, scenario medical disparities. Method Retrospective study 115 GBM from two different health-care institutions (one public and one private) Brazil who underwent post-operative RT. Results Median WT RT was 6 weeks (range, 1.3-17.6). The median OS for ≤ 13.5 months (95%CI , 9.1-17.9) > 14.2 (95%CI, 11.2-17.2) (HR 1.165,...
Glioblastoma is composed of dividing tumor cells, stromal cells and initiating CD133+ cells. Recent reports have discussed the origin glioblastoma their function in microenvironment. The present work sought to investigate multipotent mesenchymal properties primary highly purified human glioblastoma-initiating To accomplish this aim, we used following approaches: i) generation subspheres selected from cell cultures glioblastoma; ii) analysis expression pluripotency stem markers (MSC) cells;...
OBJECTIVE: Neurologic complications are known as important cause of morbidity and mortality in orthotopic heart transplantation. Our aim was to identify the frequency outcome neurologic after transplantation a prospective observational study. METHOD: From September 93 99, part our routine protocol all patients with end-stage cardiac failure were evaluated by same neurologist before at time any event (symptom or complaint) RESULTS: Out 120 candidates evaluated, 62 successfully transplanted...