A5037714476- Chromatin Remodeling and Cancer
- Glioma Diagnosis and Treatment
- Ocular Oncology and Treatments
- MicroRNA in disease regulation
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
Hospital de Câncer de Barretos
2022-2025
e20564 Background: Lung cancer accounts for 1.8 million deaths annually, making it the leading cause of cancer-related mortality, with 85% cases diagnosed as non-small cell lung (NSCLC). Immunotherapy, in particular use immune checkpoint inhibitors (ICIs), has undergone substantial advancement through employment monoclonal antibodies to regulate pivotal pathways. While ICIs have exhibited superior efficacy comparison conventional second-line chemotherapy regimens, identification reliable...
Although BRCA1/2 genetic testing in developed countries is part of the reality for high-risk patients hereditary breast and ovarian cancer (HBOC), same not true upper-middle-income countries. For that reason, this study aimed to evaluate whether test preventive strategies women at high risk HBOC are cost-effective compared performing these an country. Adopting a payer perspective, Markov model with time horizon 70 years was built delineate health states cohort healthy aged 30 fulfilled
Purpose Medulloblastomas are the most common primary malignant brain tumors in children. They divided into molecular subgroups: WNT-activated, SHH-Activated, TP53 mutant or wild type, and non-WNT/non-SHH (Groups 3 4). WNT-activated medulloblastomas usually caused by mutations CTNNB1 gene (85%–90%), remaining cases of type thought to be germline APC . So far, frequencies have been reported mainly North American European populations. The aim this study was report frequency a Latin-Iberian...
Choroid plexus tumors (CPTs) are rare intracranial neoplasms, representing <1% of all brain tumors, yet they represent 20% first-year pediatric tumors. Although these have been linked to TP53 germline mutations in the context Li–Fraumeni syndrome, their somatic driver alterations remain poorly understood. In this study, we report two cases lateral ventricle tumors: 3-yr-old male diagnosed with an atypical choroid papilloma (aCPP), and a 6-mo-old female carcinoma (CPC). We performed...