A5087274150- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Hedgehog Signaling Pathway Studies
- Cytokine Signaling Pathways and Interactions
- Blood Pressure and Hypertension Studies
- CRISPR and Genetic Engineering
- Angiogenesis and VEGF in Cancer
- Acute Lymphoblastic Leukemia research
- Circular RNAs in diseases
- Hippo pathway signaling and YAP/TAZ
- Single-cell and spatial transcriptomics
- GDF15 and Related Biomarkers
- Mycobacterium research and diagnosis
- TGF-β signaling in diseases
- Atherosclerosis and Cardiovascular Diseases
- Developmental Biology and Gene Regulation
- Malaria Research and Control
- T-cell and Retrovirus Studies
- Renal and related cancers
- Chronic Myeloid Leukemia Treatments
- Vector-borne infectious diseases
- Immune cells in cancer
Universidade de São Paulo
2011-2022
Clinics Hospital of Ribeirão Preto
2018-2022
Indiana University School of Medicine
2019
Indiana University Health
2019
Indiana University – Purdue University Indianapolis
2019
Southwest Bahia State University
2007-2016
Abstract Timed degradation of the cyclin-dependent kinase inhibitor p27 Kip1 by E3 ubiquitin ligase F-box protein SKP2 is critical for T-cell progression into cell cycle, coordinating proliferation and differentiation processes. expression regulated mitogenic stimuli Notch signaling, a key pathway in development acute lymphoblastic leukemia (T-ALL); however, it not known whether plays role T-ALL. Here, we determined that function relevant T-ALL leukemogenesis, whereas dispensable...
The inflammatory process has been considered an important mediator for the development of atherosclerosis. Interleukin-1 beta (IL1B) is a precursor interleukin-6 (IL6) in acute phase response and their levels are elevated patients with coronary artery disease. aim present study was to further investigate association IL-1B IL-6 gene polymorphisms angiographically assessed disease (CAD) African- Caucasian-Brazilians. This report analyzed IL-1B-511C>T IL-6-174G>C 667 (253 African-Brazilians 414...
Abstract Clin Chem Lab Med 2007;45:874–8.
Medulloblastoma (MB) is a malignant childhood brain tumor which at molecular level classified into least four major subtypes: WNT, SHH, group C and D differing in response to treatment. Previous studies have associated changes expression levels activation of certain HOX genes with MB development. In the present study, we investigate role two attributes acquired by cells: migration proliferation potential, as well as, vivo tumorigenic potential. We analyzed UW402, UW473, DAOY ONS-76 human...
Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility malaria. The aim this study was evaluate genotype and allele haplotype frequencies single-nucleotide (SNPs) examine their association malaria in an endemic area Brazil. One hundred twenty-six individuals from Brazilian Amazon were studied. CR1-genomic fragment amplified by PCR six SNPs haplotypes...
Materials and methods We used two human MDL tissue samples, three cell lines (UW473, UW472 DAOY), cerebellum samples primary culture. The were characterized morphologically by light microscopy immunophenotypically flow cytometry. as well as, control culture evaluated for gene expression profile of the EVF-2 lncRNA Quantitative Real Time PCR.
Advances in genomics have led to the identification of twelve relevant molecular subtypes within medulloblastoma (MB). The alpha subtype Sonic hedgehog-driven MB is resistant therapy (including smoothened inhibitors) due activation genes from non-canonical SHH pathway, such as MYCN, YAP1, or TP53. Using retrospective cohort microarray data, we found that YAP1 overexpressed and patients profiled SMO inhibitors compared good responders. Here, performed depletion via CRISPR/Cas9 two vitro...
Introduction Medulloblastoma (MB) is an embryonic neuroepithelial tumour and important development pathways, such as WNT, Sonic Hedgehog (SHH) Notch, are dysregulated on this cancer. The Notch pathway to cell differentiation proliferation it has a role in initiation progression of MB regulating downstream effectors. Skp2 gene transcriptional target been associated with protumorigenic properties some cancers, however, there no study MB. Therefore, the aim was investigate biological Notch/Skp2...
TET enzymes are responsible for catalyzing the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), during process active DNA demethylation.These differentially expressed in several tissues development and can regulate conserved signaling pathways, such as Wingless (WNT), Notch, Sonic Hedgehog (SHH) Transforming Growth Factor Beta (TGF-β).Low expression genes consequent reduction 5hmC levels have been commonly reported tumors different origins and, most cases, associated...
Abstract Introduction: Medulloblastoma (MB) is defined at molecular level into least four major subtypes: WNT, SHH, Group C and D. Previously, we have demonstrated that levels of HOX transcripts in medulloblastoma specimens correlate with their malignant phenotype. gene regulation involves long noncoding RNAs (lncRNAs), the epigenetic activator Trithorax group (TrxG) repressors polycomb (PcG). Therefore, performed transcriptoma profiling adult MBs normal cerebellum samples to elucidate...
Abstract Introduction: Medulloblastoma is an embryonal neuroepithelial tumor of the cerebellum and accounts for 15-30% all pediatric cancer central nervous system (CNS) 1-3% adult brain tumors. a heterogeneous classified in four main subgroups: WNT, SHH, Group 3 4. The elucidation biological meaning these subgroups requires understanding interactions among several molecular pathways that are deregulated during oncogenesis resulting clinicalpathological differences. goal this study to...
Abstract HOX genes are a family of homeodomain-containing transcription factors defined as master development, altered in cancer cells and thus having implications for tumorigenesis. Developmental have been recognized one the keys to understanding tumor progression some type cancers. This study aimed correlate gene expression profile with tumorigenic potential medulloblastoma cell lines (MCL). We used three human MCL, UW473, UW472 DAOY two cerebellum primary cultures (CPC). The MCL CPC were...
Abstract Tumor expansion is dependent on neovascularization, a process that requires sustained new vessel formation. Although the critical role of angiogenesis by endothelial sprouting in this process, controversy still prevails whether vasculogenesis, involving bone marrow (BM)-derived cells, does contribute to process. The objective study was investigate contributions BM-derived cells tumor vasculature, melanoma model using chimeric GFP mice. Methodology: First, wild-type C57BL/6 mice were...
O paradigma da biologia molecular é definido pelo dogma central, o qual basicamente subdivido em: replicação do DNA (ácido desoxirribonucléico), que permite a perpetuação informação gênica; transcrição, converte em uma fita de RNA ribonucléico) complementar; e tradução, contida no RNAm ribonucléico mensageiro) proteínas. Tais processos ocorrem por meio código genético, composto conexões entre códons seus respectivos aminoácidos. [...]
A Hipertensão Arterial Sistêmica é considerada um fator de risco para a doença arterial coronariana (DAC).A hipertensão e aterosclerose são as duas maiores doenças do sistema estão intimamente associadas.O renina-angiotensina-aldosterona (SRAA) tem sido identificado como uma via crítica o controle da pressão sanguínea funções renais.Este possui papel importante na regulação sanguínea, influenciando homeostase sal/água consequentemente possuindo relação íntima com processo hipertensão.Já que...