A5076785114- Adrenal and Paraganglionic Tumors
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Hormonal Regulation and Hypertension
- Hedgehog Signaling Pathway Studies
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Ferroptosis and cancer prognosis
- Chromatin Remodeling and Cancer
- Genetic Syndromes and Imprinting
- Renal and related cancers
- RNA Research and Splicing
- interferon and immune responses
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- FOXO transcription factor regulation
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer Genomics and Diagnostics
- Animal Genetics and Reproduction
Universidade de São Paulo
2016-2025
Clinics Hospital of Ribeirão Preto
2022-2023
Universidade Estadual Paulista (Unesp)
2014-2015
Pediatric adrenocortical tumors (ACTs) are rare, highly heterogeneous neoplasms with limited therapeutic options, making the investigation of new targets potential or prognostic purposes urgent. The PRKAB2 gene produces one subunits AMP-activated protein kinase (AMPK) complex and has been associated cancer. However, little is known about role AMPK plays in ACTs. We have evaluated how clinical biological characteristics 63 pediatric patients ACTs conducted vitro studies on human NCI-H295R ACC...
Abnormal placental development is frequent in nuclear transfer (NT) pregnancies and likely to be associated with altered epigenetic reprogramming. In the present study, fetal measurements were taken on Day 60 of gestation cows produced by AI, IVF NT. Placentas collected subjected histological evaluation, expression genes important trophoblast differentiation imprinted gene pleckstrin homology-like domain, family A, member 2 (PHLDA2), as well chromatin immunoprecipitation (ChIP) for histone...
Abstract Pediatric adrenocortical tumors (ACT) are rare aggressive neoplasms with heterogeneous prognosis. Despite extensive efforts, identifying reliable prognostic factors for pediatric patients ACT remains a challenge. MicroRNA (miRNA) signatures have been associated cancer diagnosis, treatment response, and prognosis of several types cancer. However, the role miRNAs has poorly explored in ACT. In this study, we performed miRNA microarray profiling on cohort 37 nine nonneoplastic adrenal...
Abstract In vitro production (IVP) of bovine embryos is not only great economic importance to the cattle industry, but also an important model for studying embryo development. The aim this study was evaluate histone modification, H3R26me2 during pre-implantation development IVP cultured with or without serum supplementation and how these in treatments compared vivo at morula stage. After maturation fertilization, were either 0 2.5% fetal (FBS). Development evaluated collected fixed different...
Abstract Adrenocortical carcinoma (ACC) is a rare, but highly aggressive cancer of the adrenal cortex with generally poor prognosis. Despite being completely resected ACCs present high risk recurrence. Musashi‐2 ( MSI2 ) has recently been recognized as potential prognostic biomarker and therapeutic target in many cancers. However, no studies have evaluated clinical significance expression ACC. Here, we addressed its association ACC prognosis clinicopathological parameters. was analyzed TCGA,...
Abstract The Group 3 Medulloblastoma ( Grp3-MB ) is an aggressive molecular subtype with a high incidence of metastasis and deaths. In this study, were used RNA sequencing data RNA-Seq from Brazinian cohort MBs to identify hub genes associated the metastatic risk. Data validation performed by using multiple large datasets (GSE85217, GSE37418, EGAS00001001953). DESeq2 package in R software was differentially expressed DEGs our data. accessed construct modules/graphs coexpression through...
Proper implantation and placental formation are crucial for the continuity of mammalian species. Embryonic developments under intense genetic epigenetic control, such as regulation differentiation pluripotent cells into highly specialised fetal cells. In present study objectives were to evaluate expression control imprinted gene PHLDA2, a maternally expressed that appears be regulator growth, in cotyledonary inter-cotyledonary tissues bovine placentas on Day 60 pregnancies produced by embryo...
Abstract Groups (Grp) 3 and 4 are aggressive molecular subgroups of medulloblastoma (MB), with high rates leptomeningeal dissemination. To date, there is still a paucity biomarkers for these subtypes MBs. In this study, we investigated the clinical significance biological functions Musashi-1 ( MSI1) in Grp3 Grp4-MBs. First, assessed expression profile MSI1 59 primary MB samples (15-WNT, 18-SHH, 9-Grp3, 17-Grp4 subgroups) by qRT-PCR. mRNA levels were also validated an additional public...
Abstract Groups (Grp) 3 and 4 are aggressive molecular subgroups of medulloblastoma (MB), with high rates leptomeningeal dissemination. To date, there is still a paucity biomarkers for these subtypes MBs. The RNA-binding protein Musashi-1 ( MSI1 ) neural stem cell marker, characterized as gene translation regulator associated oncogenicity in several human cancers. In this study, we investigated the clinical significance biological functions Grp3/Grp4-MBs. First, assessed expression profile...