A5072749374- Parkinson's Disease Mechanisms and Treatments
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Immune cells in cancer
- Olfactory and Sensory Function Studies
- Neurological disorders and treatments
- Inflammasome and immune disorders
- Influenza Virus Research Studies
- interferon and immune responses
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Inflammation biomarkers and pathways
- Epilepsy research and treatment
- Sepsis Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Signaling Pathways in Disease
- Chemokine receptors and signaling
- Galectins and Cancer Biology
- Child Nutrition and Feeding Issues
- Adenosine and Purinergic Signaling
- Tryptophan and brain disorders
- Neurological diseases and metabolism
- Phagocytosis and Immune Regulation
- Biochemical Analysis and Sensing Techniques
Hospital Universitario Virgen del Rocío
2015-2024
Instituto de Biomedicina de Sevilla
2015-2024
Universidad de Sevilla
2015-2024
University of Oxford
2018
Karolinska Institutet
2016
Consejo Superior de Investigaciones Científicas
2015
University of Cambridge
2012
Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations neuroinflammatory diseases. Although toll-like receptor 4 (TLR4) microglia's inflammatory is fully acknowledged, little known about endogenous ligands that trigger TLR4 activation. Here, we report galectin-3 (Gal3) released acts as an paracrine ligand. Gal3-TLR4 interaction was further confirmed murine model (intranigral lipopolysaccharide [LPS] injection) and human stroke subjects....
Abstract Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads brain through vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) humans can progress with emergence of pathogenic α‐synuclein (α‐syn) gastrointestinal tract midbrain dopaminergic neurons. Methods We have analysed gut ventral from subjects previously diagnosed IBD form a DSS‐based rat model inflammation terms...
Microglia are resident brain macrophages that can phagocytose dead, dying or viable neurons, which may be beneficial detrimental in inflammatory, ischaemic and neurodegenerative pathologies. Cell death caused by phagocytosis of an otherwise cell is called 'primary phagocytosis' 'phagoptosis'. Calreticulin (CRT) exposure on the surface cancer cells promote their via LRP (low-density lipoprotein receptor-related protein) macrophages, but it not known whether this occurs with neurons...
Abstract In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles RIPK1 in regulating hematopoiesis macrophage differentiation, proinflammatory activation, cell death pathways. Knock-out hiPSCs demonstrated that protein is not required for erythro-myeloid differentiation. Using a well-established differentiation protocol, knock-out did block iPSC-derived macrophages, which displayed similar phenotype WT...
Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative diseases, particularly Parkinson's disease (PD). We recently uncovered a completely novel and unexpected role for caspase-8 its downstream substrates caspase-3/7 control associated neurotoxicity to dopaminergic cells. To demonstrate genetic evidence, mice bearing floxed allele CASP8 were crossed onto transgenic line expressing Cre under Lysozyme 2 gene. Analysis...
// Maria Jose Oliva-Martin 1,2,3 , Luis Ignacio Sanchez-Abarca 3 Johanna Rodhe 2 Alejandro Carrillo-Jimenez 1 Pinelopi Vlachos Antonio Herrera Albert Garcia-Quintanilla Teresa Caballero-Velazquez Perez-Simon 3,* Bertrand Joseph 2,* and Venero 1,* Department of Biochemistry Molecular Biology, Faculty Pharmacy, Universidad de Sevilla, Spain Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden Instituto Biomedicina Sevilla (IBiS)-/CSIC/ * Co-senior authors...
ABSTRACT According to Braak’s hypothesis, it is plausible that Parkinsońs disease (PD) starts in the enteric nervous system (ENS) spread brain via vagus nerve. Thus, we were wondering whether human inflammatory bowel diseases (IBD) can progress with appearance of pathogenic α-synuclein (α-syn) gastrointestinal tract and midbrain dopaminergic neurons. Analysis sections from IBD patients demonstrated presence phosphorylated α-syn both myenteric (Auerbach’s) submucosal (Meissner’s) plexuses....
Influenza A virus infection usually causes a mild to moderately severe respiratory disease in humans. However, with the 1918 H1N1 pandemic or highly pathogenic avian influenza viruses (HPAIV) of H5N1 subtype, can lead viral pneumonia, systemic and death. The molecular processes that determine outcome are multifactorial involve complex interplay between host, viral, bacterial factors 1 . it is generally accepted strong innate immune dysregulation known as ‘cytokine storm’ contributes...