Hiroshi Toyama

ORCID: 0000-0002-5341-1693
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About
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Research Areas
  • Medical Imaging Techniques and Applications
  • Advanced MRI Techniques and Applications
  • Radiomics and Machine Learning in Medical Imaging
  • Advanced X-ray and CT Imaging
  • Cardiac Imaging and Diagnostics
  • Radiation Dose and Imaging
  • MRI in cancer diagnosis
  • Lung Cancer Diagnosis and Treatment
  • Cerebrovascular and Carotid Artery Diseases
  • Radiopharmaceutical Chemistry and Applications
  • Atomic and Subatomic Physics Research
  • Cardiovascular Function and Risk Factors
  • Neuroscience and Neuropharmacology Research
  • Acute Ischemic Stroke Management
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Advanced Antenna and Metasurface Technologies
  • Medical Imaging and Pathology Studies
  • Glioma Diagnosis and Treatment
  • Advanced Radiotherapy Techniques
  • Intracranial Aneurysms: Treatment and Complications
  • Photonic Crystals and Applications
  • Advanced Neuroimaging Techniques and Applications
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Bone and Joint Diseases
  • Sarcoidosis and Beryllium Toxicity Research

Fujita Health University
2016-2025

Fujita Health University Hospital
2012-2024

Canon (Japan)
2022-2023

Canon Medical Systems Corporation (Japan)
2023

Nagoya University
2021

Kanazawa Gakuin University
2019

Osaka University
2018

University of the Ryukyus
2017

Toshiba (United States)
2016

Toyota Memorial Hospital
2016

The authors developed and applied two new linearized reference tissue models for parametric images of binding potential ( BP) relative delivery R 1 ) [ 11 C]DASB positron emission tomography imaging serotonin transporters in human brain. original multilinear model (MRTM O was modified (MRTM) used to estimate a clearance rate k′ 2 from the cerebellum (reference). Then, number parameters reduced three (MRTM2) by fixing . resulting BP estimates were compared with corresponding nonlinear models,...

10.1097/01.wcb.0000085441.37552.ca article EN Journal of Cerebral Blood Flow & Metabolism 2003-09-01

Background Deep learning reconstruction (DLR) may improve image quality. However, its impact on diffusion-weighted imaging (DWI) of the prostate has yet to be assessed. Purpose To determine whether DLR can quality MRI at b values ranging from 1000 sec/mm2 5000 in patients with cancer. Materials and Methods In this retrospective study, images obtained DWI a value 0 sec/mm2, (DWI1000), 3000 (DWI3000), (DWI5000) consecutive biopsy-proven cancer January June 2020 were reconstructed without DLR....

10.1148/radiol.204097 article EN Radiology 2022-02-01

In an attempt to improve neuroreceptor distribution volume (V) estimates, the authors evaluated three alternative linear methods Logan graphical analysis (GA): GA using total least squares (TLS), and two multilinear analyses, MA1 MA2, based on mathematical rearrangement of equation two-tissue compartments, respectively, simulated actual PET data receptor tracers, [(18)F]FCWAY [(11)C]MDL 100,907. For simulations, all decreased noise-induced bias (up 30%) at expense increased variability. The...

10.1097/01.wcb.0000038000.34930.4e article EN Journal of Cerebral Blood Flow & Metabolism 2002-10-01

The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database healthy controls from the common systems available in Japan. This study included 510 sets data 256 (116 men and 140 women; age range, 30–83 years) acquired eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only using Chang method (ChangACNOSC) X-ray CT (CTACNOSC), both (ChangACSC) (CTACSC). These images analyzed Southampton method. outcome measure...

10.1007/s00259-018-3976-5 article EN cc-by European Journal of Nuclear Medicine and Molecular Imaging 2018-02-24

Lung cancer is a leading cause of death worldwide. Although computed tomography (CT) examinations are frequently used for lung diagnosis, it can be difficult to distinguish between benign and malignant pulmonary nodules on the basis CT images alone. Therefore, bronchoscopic biopsy may conducted if malignancy suspected following examinations. However, biopsies highly invasive, patients with undergo many unnecessary biopsies. To prevent this, an imaging diagnosis high classification accuracy...

10.1155/2019/6051939 article EN BioMed Research International 2019-01-02

Abstract The derivation of dopamine neurons is one the best examples clinical potential embryonic stem (ES) cells, but long-term function grafted has not been established. Here, we show that, after transplantation into an animal model, derived from mouse ES cells survived for over 32 weeks, maintained midbrain markers, and had sustained behavioral effects. Microdialysis in animals showed that (DA) release was induced by depolarization pharmacological stimulants. Positron emission tomography...

10.1634/stemcells.2006-0386 article EN Stem Cells 2006-12-14

A very efficient and accurate method to characterize two-dimensional (2-D) electromagnetic scattering from multilayered periodic arrays of parallel circular cylinders is presented, using the lattice sums technique, aggregate T-matrix algorithm, generalized reflection transmission matrices for a layered system. The quite general applies various configurations 2-D arrays. unit cell array can contain two or more cylinders, which may be dielectric, conductor, gyrotropic medium, their mixture...

10.1109/tap.2004.834440 article EN IEEE Transactions on Antennas and Propagation 2004-10-01

Background:Limitations of coronary computed tomography (CTA) include false-positive stenosis at calcified lesions and assessment in-stent patency. A prototype ultra-high resolution (U-HRCT: 1,792 channels 0.25-mm slice thickness×128 rows) with improved spatial was developed. We assessed the diagnostic accuracy artery using U-HRCT.

10.1253/circj.cj-17-1281 article EN Circulation Journal 2018-05-08

Recently, two methods have been proposed for regional cerebral blood flow (rCBF) quantitation using [ 123 I]iodoamphetamine (IMP) and single-photon emission computed tomography (SPECT). The table look-up (TLU) method has shown to provide both rCBF volume of distribution, V d , images from SPECT scans, while a single-scan autoradiographic (ARG) technique provided fixed assumed . In methods, single sample was referred calibrate the previously determined standard input function present...

10.1097/00004647-199609000-00003 article EN Journal of Cerebral Blood Flow & Metabolism 1996-09-01

Abstract Aims In the updated guidelines for cardiac sarcoidosis (CS) proposed by Japanese Circulation Society (JCS), definition of isolated CS (iCS) was established first time. This prompted us to examine characteristics patients with including iCS according them reviewing undergoing 18 F‐fluoro‐2‐deoxyglucose positron‐emission tomography/computerized tomography (FDG‐PET/CT), compared those determined conventional international criteria. Methods and results From 2013 2019, 94 (61 ± 15 years,...

10.1002/ehf2.12853 article EN cc-by-nc ESC Heart Failure 2020-06-24

Sudden death in multiple system atrophy (MSA) is caused by decreased serotonergic innervation, but there no routine test method for this decrease. In addition to dopamine transporters, iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (

10.22038/aojnmb.2024.78274.1557 article EN PubMed 2025-01-01

This study evaluated (18)F-labeled IMPY [6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine] derivatives as agents for imaging beta-amyloid plaque with positron emission tomography (PET). The precursor radiolabeling and reference compounds was synthesized in up to five steps from commercially accessible starting materials. One of the two N-methyl groups substituted either a 3-fluoropropyl (FPM-IMPY) or 2-fluoroethyl (FEM-IMPY) group. FPM-IMPY FEM-IMPY were found have moderate...

10.1021/jm030477w article EN Journal of Medicinal Chemistry 2004-03-20

Purpose: To preliminarily evaluate the feasibility and potential diagnostic utility of whole-brain perfusion computed tomography (CT) performed with a prototype 256–detector row CT system over an extended range covering entire brain to assess ischemic cerebrovascular disease. Materials Methods: Institutional review board approval informed consent were obtained. Eleven cases in 10 subjects (six men, four women; mean age, 64.3 years) intra- or extracranial stenosis retrospectively evaluated...

10.1148/radiol.2501071809 article EN Radiology 2008-12-17

ABSTRACT Introduction : To visualize peripheral nerves in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), we used MR imaging. We also quantified the volumes of brachial and lumbar plexus their nerve roots. Methods Thirteen CIDP 12 healthy volunteers were enrolled. Whole‐body neurography based on diffusion‐weighted whole‐body imaging background body signal suppression (DWIBS) was performed. Peripheral calculated from serial axial images. Results The nervous system...

10.1002/mus.25368 article EN Muscle & Nerve 2016-08-08

Background Pulmonary MRI with ultrashort echo time (UTE) has been compared chest CT for nodule detection and classification. However, direct comparisons of these methods' capabilities Lung Screening Reporting Data System (Lung-RADS) evaluation remain lacking. Purpose To compare the pulmonary UTE those standard- or low-dose thin-section Lung-RADS Materials Methods In this prospective study, (270 mA 60 mA, respectively) were used to examine consecutive participants enrolled between January...

10.1148/radiol.211254 article EN Radiology 2021-11-30
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