A5073938285- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Lysosomal Storage Disorders Research
- Peripheral Neuropathies and Disorders
- Advanced MRI Techniques and Applications
- Autophagy in Disease and Therapy
- Botulinum Toxin and Related Neurological Disorders
- Cellular transport and secretion
- Autoimmune Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- IgG4-Related and Inflammatory Diseases
- Alzheimer's disease research and treatments
- Infectious Encephalopathies and Encephalitis
- Cerebrospinal fluid and hydrocephalus
- Neurotransmitter Receptor Influence on Behavior
- Mitochondrial Function and Pathology
- Sphingolipid Metabolism and Signaling
- Neuroscience and Neuropharmacology Research
- Venous Thromboembolism Diagnosis and Management
- Dementia and Cognitive Impairment Research
- Restless Legs Syndrome Research
- Functional Brain Connectivity Studies
- Cerebral Venous Sinus Thrombosis
- Neurological and metabolic disorders
Fujita Health University
2016-2025
Fujita Health University Hospital
2020-2024
Nagoya University
2012-2015
Meitetsu Hospital
2010
Gifu University
2005
Abstract Recently, the genetic variability in lysosomal storage disorders has been implicated pathogenesis of Parkinson’s disease. Here, we found that variants prosaposin (PSAP), a rare causative gene various types disorders, are linked to Genetic mutation screening revealed three pathogenic mutations saposin D domain PSAP from families with autosomal dominant Whole-exome sequencing no other previously identified disease-causing or disorder-causing genes. A case-control association study two...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 466:249-259 (2012) - DOI: https://doi.org/10.3354/meps09939 Spatio-temporal responses of black-tailed gulls natural and anthropogenic food resources Ken Yoda1,*, Naoki Tomita2,4, Yuichi Mizutani1, Akira Narita3, Yasuaki Niizuma2 1Graduate School Environmental Studies, Nagoya University, Furo-cho, Chikusa-ku,...
ABSTRACT Introduction : To visualize peripheral nerves in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), we used MR imaging. We also quantified the volumes of brachial and lumbar plexus their nerve roots. Methods Thirteen CIDP 12 healthy volunteers were enrolled. Whole‐body neurography based on diffusion‐weighted whole‐body imaging background body signal suppression (DWIBS) was performed. Peripheral calculated from serial axial images. Results The nervous system...
Sudden death in multiple system atrophy (MSA) is caused by decreased serotonergic innervation, but there no routine test method for this decrease. In addition to dopamine transporters, iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (
Dysphagia significantly impacts prognosis in individuals with multiple system atrophy (MSA). While video-based assessments are practical, their limited availability highlights the need for a simple tool such as Severity Scale (DSS) clinical practice. To evaluate utility of DSS assessing dysphagia MSA patients and its correlations indices. We examined 43 using other measures, including Unified Rating (UMSARS) cerebrospinal fluid 5-hydroxyindoleacetic acid levels. As follow-up, 11 underwent...
Parkinson's disease (PD) is associated with cognitive decline through multiple mechanisms, including Alzheimer's (AD) pathology and cortical Lewy body involvement. However, its underlying mechanisms remain unclear. Recently, AD-related plasma biomarkers have emerged as potential tools for predicting abnormal pathological protein accumulation. We aimed to investigate the association between in PD patients.Plasma were measured 70 patients (49 nondemented (PDND) 21 dementia (PDD)) 38 healthy...
<h2>Abstract</h2><h3>Introduction</h3> The King's Parkinson's Disease Pain Scale (KPPS)/King's Questionnaire (KPPQ) was developed as a tool to quantitatively assess pain in patients with disease (PwPD). Here, we conducted Japanese multicenter validation study verify the reliability of KPPS/KPPQ PwPD. <h3>Methods</h3> PwPD, ≥20 years, unexplained were included; those definitive primary cause other than PD excluded. A total 151 who fulfilled criteria analyzed, and test-retest investigated 25...
Distinguishing between central nervous system lymphoma (CNSL) and CNS infectious and/or demyelinating diseases, although clinically important, is sometimes difficult even using imaging strategies conventional cerebrospinal fluid (CSF) analyses. To determine whether detection of genetic mutations enables differentiation these diseases the early CNSL, we performed mutational analysis CSF liquid biopsy technique.In this study, extracted cell-free DNA from (CSF-cfDNA) CNSL (N = 10), disease 10)...
ABSTRACT BACKGROUND We investigated the association between path-integration (PI) errors related to entorhinal cortex function detectable using a 3D virtual reality (VR) navigation system and various biomarkers explore its potential as an early AD indicator. METHODS The PI capabilities of 111 healthy adults were assessed head-mounted VR system. Demographic cognitive assessments, AD-related plasma biomarkers, apolipoprotein E genotypes also evaluated. Predictive factors for identified...
The authors sought to delineate the characteristics of female alcoholics with eating disorders.The study subjects were 29 Japanese outpatients and inpatients, 30 years age or younger, DSM-III-R diagnoses either alcohol dependence abuse disorders. Twenty-one within same range who did not have disorders served as comparison group. social familial backgrounds, clinical course, symptoms two groups compared use a structured interview form developed for study.Ninety-three percent had bulimia...
Background: The development of acute multiple embolic infarctions (AMEI) resulting from cancer is known as Trousseau's syndrome (TS). At present, however, there no good marker for predicting the prognosis TS patients. In present study, we evaluated use serial D-dimer levels a prognostic TS. Methods: This retrospective cohort study included 1,409 consecutive ischemic stroke We selected group patients with showing AMEI (n = 38; group) and atrial fibrillation (Af) 35; Af controls. Serial were...
Background: As mutations in glucocerebrosidase 1 (GBA1) are a major risk factor for Parkinson’s disease (PD), decreased GBA1 activity might play an important role the pathogenesis of disease. However, there currently no reports on glucosylceramide levels cerebrospinal fluid (CSF) PD. Objective: We investigated whether accumulation and abnormal immune status brain associated with Methods: measured by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) as well...
This review summarizes improvements in understanding the pathophysiology and early clinical symptoms of multiple system atrophy (MSA) advancements diagnostic methods disease-modifying therapies for condition. In 2022, Movement Disorder Society proposed new criteria to develop promote trials MSA since second consensus was 2008. Regarding pathogenesis, cutting-edge findings have accumulated on interactions α-synuclein, neuroinflammation, oligodendroglia with neurons. neuroimaging, introducing...
Abstract Herpes simplex encephalitis (HSE) is an acute form of that can lead to poor neurological outcomes. Although the exact pathogenesis HSE remains elusive, recent reports suggest a significant role for postinfectious immune‐inflammatory processes in central nervous system (CNS). This study aimed clarify association between CNS autoimmune responses and clinical presentation patients with HSE, focusing on cerebrospinal fluid (CSF) characteristics, particularly IgG index. We...
RNase L is activated by the binding of unusual 2',5'-linked oligoadenylates (2-5A) and acts as effector enzyme 2-5A system, an interferon-induced anti-virus mechanism. Efforts have been made to understand mechanism, not only for scientific interests but also prospects that understanding such mechanisms lead new remedies viral diseases. We recently elucidated crystal structure ankyrin repeat domain human complexed with 2-5A. To determine contributions amino acid residues surrounding site,...