Seiko Hirota

ORCID: 0000-0002-4384-5893
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About
Contact & Profiles
Research Areas
  • Radiation Dose and Imaging
  • Radiation Effects and Dosimetry
  • Radiation Therapy and Dosimetry
  • Insect and Pesticide Research
  • Parkinson's Disease Mechanisms and Treatments
  • Advanced Radiotherapy Techniques
  • Neurological disorders and treatments
  • Radioactivity and Radon Measurements
  • Effects of Radiation Exposure
  • Radioactive contamination and transfer
  • Genetic Neurodegenerative Diseases
  • Radiation Detection and Scintillator Technologies
  • bioluminescence and chemiluminescence research
  • Acute Ischemic Stroke Management
  • Listeria monocytogenes in Food Safety
  • Climate Change and Health Impacts
  • Risk Perception and Management
  • Autoimmune Neurological Disorders and Treatments
  • Astrophysics and Cosmic Phenomena
  • Climate Change, Adaptation, Migration
  • Sphingolipid Metabolism and Signaling
  • Monoclonal and Polyclonal Antibodies Research
  • Ocular Infections and Treatments
  • Electrostatic Discharge in Electronics
  • Medical and Biological Ozone Research

Hiroshima University
2019-2025

Japan Atomic Energy Agency
2019-2023

The University of Tokyo
2022-2023

Hirosaki University
2022-2023

National Institutes for Quantum Science and Technology
2019-2023

Nagasaki University
2023

Japanese Society of Medical Oncology
2022

Hitachi (Japan)
2022

Central Research Institute of Electric Power Industry
2019-2022

University of the Ryukyus
2022

The circulatory system receives ionizing radiation at various dose rates. Given mounting epidemiological evidence of elevated risks for diseases the (DCS), International Commission on Radiological Protection recently recommended first ever threshold DCS. However, very little knowledge exists about whether effects differ with rates and among tissues system. Here, we investigated impact in carotid artery (CA) compared it aorta. CA was obtained from mice irradiated same total that delivered...

10.1038/s41598-025-92710-5 article EN cc-by Scientific Reports 2025-03-05

Our previous work indicated the greater magnitude of damage to thoracic aorta at 6 months after starting 5 Gy irradiation in descending order exposure X-rays 25 fractions > acute γ-rays 100 ≫ chronic γ-rays, which limitations study included a lack data for fractionated γ-ray exposure. To better understand effects dose protraction and radiation quality, present examined changes fractions, compared its biological effectiveness with five other regimens.

10.1080/09553002.2023.2242939 article EN International Journal of Radiation Biology 2023-07-31

Abstract With advances in high-dose-rate (HDR) brachytherapy, the importance of quality assurance (QA) is increasing to ensure safe delivery treatment by measuring dose distribution and positioning source with much closer intervals for highly active sources. However, conventional QA time-consuming, involving use several different measurement tools. Here, we developed simple method HDR brachytherapy based on imaging Cherenkov emission evaluated its performance. Light from pure water...

10.1038/s41598-020-60519-z article EN cc-by Scientific Reports 2020-02-27

Abstract A novel formula of crosslinked polyvinyl alcohol (PVA) with glutaraldehyde (GTA), a tri-iodide complex, and glucono-δ-lactone (GDL) acid for gel dosimetry was investigated in the present study. The objectives this study were to evaluate formula’s dose response properties through spectrophotometry possible reusability by reannealing. After production, samples irradiated from 1 70 Gy gamma-rays Cs-137 source constant rate 0.857 Gy/min. Spectrum data obtained using UV-Vis...

10.1088/1742-6596/1305/1/012034 article EN Journal of Physics Conference Series 2019-08-01

Abstract This study investigates the use of electron spin resonance (ESR) signals from human fingernails for retrospective dosimetry as part radiation disaster response, focusing on variabilities individual responses to radiation. Samples were collected 7 adult donors (Asian type) and irradiated 35 Gy 70 gamma-rays a Cs-137 source at dose rate 0.857 Gy/min. All measured 39 days with an X-band ESR spectrometer stored in darkness inside vacuum desiccator (30% humidity, 20°C) between...

10.1088/1742-6596/1248/1/012072 article EN Journal of Physics Conference Series 2019-06-01

The purpose of this study was to evaluate the effects exposure radiation caused by an atomic bomb in survivors on vascular function and structure relationships dose from with survivors.Flow-mediated vasodilation (FMD) nitroglycerine-induced (NID) as indices function, brachial-ankle pulse wave velocity (baPWV) index structure, brachial artery intima-media thickness (IMT) were measured 131 1,153 control subjects who not exposed bomb. Ten estimated a cohort Atomic Bomb Survivors Hiroshima...

10.3389/fcvm.2023.1122794 article EN cc-by Frontiers in Cardiovascular Medicine 2023-02-17

A total of seven Japanese laboratories participated in an intercomparison study to estimate the dose given tooth enamel samples, using electron spin resonance method. Each four participating prepared a set Four each consisting standard aliquots irradiated from 100 2000 mGy and three samples with 'unknown' between 140 960 mGy, were intended eliminate bias sample preparation. Although not all measured sets major finding was that systematic biases estimating doses may be caused by differences...

10.1093/rpd/ncad150 article EN Radiation Protection Dosimetry 2023-06-15

We are developing a hybrid photo-detector (HPD) and the avalanche diode (AD) used inside for next generation large underground water Cherenkov detector, Hyper-Kamiokande (HK).The performance of AD that 8-inch HPD, such as gain, single photoelectron charge resolution, dark rate, measured under different temperatures.The HPD's can be estimated more precisely HK operation environment if its thermal effect is known.Furthermore, it concluded temperature dependence gain mainly due to AD's because...

10.7566/jpscp.8.023006 article EN Proceedings of the 2nd International Symposium on Science at J-PARC — Unlocking the Mysteries of Life, Matter and the Universe — 2015-09-25

The Research Institute for Radiation Biology and Medicine (RIRBM) of Hiroshima University has been conducting a cohort study atomic bomb survivors (ABS). Cohort members include those who were issued an Atomic Bomb Health Handbook from the local government. A series dosimetry systems ABS developed at RIRBM to evaluate health effects associated with radiation exposure. framework used estimate individual doses in our is mainly based on Dosimetry System 86, its revisions by Effect Foundation....

10.1093/jrr/rrab020 article EN cc-by-nc Journal of Radiation Research 2021-03-23

The retrospective dosimetry that follows accidental X-ray exposure is becoming more significant for improving radiation diagnosis and treatment. We investigated the dosimetric properties of electron spin resonance (ESR) signals in irradiated fingernails under conditions resemble realistic situations. collected from 12 Japanese donors between ages 30 to 70. sampled were utilized irradiation, mechanical stimulation background measurements. also 10 toenails one evaluate their differences...

10.1093/jrr/rrab027 article EN cc-by-nc Journal of Radiation Research 2021-03-29

Abstract We report the phenomenon whereby electron spin resonance signal of human nails intensify after irradiation. Forty nail samples from three donors were divided into groups (X-ray irradiated, γ-ray and control). The extent intensified irradiation was proportional to given dose under 11% humidity at 20 °C. This result seemed contradict previous studies, reporting fading. Based on literature our experimental results, we constructed a model taking both decay increase consideration. Our...

10.1007/s10967-020-07540-8 article EN cc-by Journal of Radioanalytical and Nuclear Chemistry 2021-01-05

A 74-year-old woman was hospitalized due to dysuria, weakness and dysesthesia of the lower extremities. She in an immunosuppressed state following administration methylprednisolone therapy for idiopathic interstitial pneumonia. Cerebrospinal fluid blood cultures were negative, no infectious biomarkers found. gadolinium (Gd)-enhanced T1-weighted image magnetic resonance imaging (MRI) revealed disseminated nodular lesions along spinal cord. We suspected a diagnosis seronegative deep mycosis...

10.2169/internalmedicine.54.3148 article EN Internal Medicine 2015-01-01

We have been developing a new hybrid photo-detector (HPD) for Hyper-Kamiokande, which is proposed next generation megaton-class water Cherenkov detector.The prototypes of the 50 cm HPD with φ 5 mm avalanche diode (AD) [1] and 20 AD (R12850, Hamamatsu Photonics K.K.) were designed produced after successful fabrication HPD.For AD, transit time spread, linearity temperature dependence gain evaluated.For our target design two solutions by segmented transformer coupling tried to suppress capacity...

10.22323/1.252.0022 article EN cc-by-nc-nd 2016-06-01

Objectives Since the Fukushima Daiichi Nuclear Power Plant accident caused by Great East Japan Earthquake, many people in Prefecture have been concerned about effects of radiation on their offspring. Although this fear should be relieved since no epidemiological study has shown evidential cases, situations wherein some misunderstood existence evidence independently reported. Therefore, study, we examined relationship between knowledge and anxiety radiation-based genetic using a survey mailed...

10.11236/jph.22-053 article EN PubMed 2023-07-25
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