A5101621529- Optical Network Technologies
- Advanced Photonic Communication Systems
- Photonic and Optical Devices
- Advanced Wireless Communication Techniques
- Viral Infections and Immunology Research
- Semiconductor Lasers and Optical Devices
- Error Correcting Code Techniques
- Advanced Optical Network Technologies
- Optical Wireless Communication Technologies
- Radio Frequency Integrated Circuit Design
- Millimeter-Wave Propagation and Modeling
- Monoclonal and Polyclonal Antibodies Research
- Cardiac electrophysiology and arrhythmias
- PAPR reduction in OFDM
- Power Line Communications and Noise
- GaN-based semiconductor devices and materials
- graph theory and CDMA systems
- Telecommunications and Broadcasting Technologies
- Advanced Power Amplifier Design
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- Advanced Fiber Laser Technologies
- Blind Source Separation Techniques
- Biofuel production and bioconversion
- Cardiovascular Function and Risk Factors
Mitsubishi Electric (Japan)
2016-2025
Niigata Prefectural Shibata Hospital
2008-2024
Center for Global Health
2023
National Center for Global Health and Medicine
2023
Osaka University
1992-2022
University of Electro-Communications
2008-2022
Nitobe Memorial Nakano General Hospital
2018-2022
Mitsubishi Electric (United States)
2012-2022
Information Technology Laboratory
2022
Chalmers University of Technology
2017-2020
In this paper, we examine the performance of several modulation formats in more than four dimensions for coherent optical communications systems. We compare two high-dimensional design methodologies based on spherical cutting lattices and block coding a 'base constellation' binary phase shift keying (BPSK) each dimension. The performances generated with these is analyzed asymptotic signal-to-noise ratio regime an additive white Gaussian noise (AWGN) channel. then study application both types...
The implementation difficulties of combining distribution matching (DM) and dematching (invDM) for probabilistic shaping (PS) with soft-decision forward error correction (FEC) coding can be relaxed by reverse concatenation, which the FEC decoding lies inside algorithms. PS seemingly achieve performance close to Shannon limit, although there are practical challenges that need carefully addressed. We propose a hierarchical DM (HiDM) scheme, having fully parallelized input-output interfaces...
Abstract IL-22 is one of several cytokines with limited homology to IL-10. However, the biological activities are mostly unknown. The purpose this study was evaluate effect on rat experimental autoimmune myocarditis (EAM) and elucidate an aspect IL-22. Rats were immunized day 0; IL-22-Ig-treated rats injected pCAGGS-IL-22-Ig control pCAGGS-Ig using hydrodynamics-based gene delivery 1 or 6. IL-22-Ig therapy administered 6 after immunization effective in controlling EAM as monitored by heart...
Distant metastasis is the major cause of death in colorectal cancer (CRC) patients. To identify genes influencing prognosis patients with CRC, we compared gene expression primary tumors and without distant using an oligonucleotide microarray. We also examined candidate 100 CRC by quantitative real-time reverse transcription PCR studied relationship between its CRC. As a result, identified MUC12 as involved processes microarray analysis. Quantitative showed that was significantly lower...
Presently, several researchers are increasingly focusing on producing butanol as the next‐generation fuel by acetone‐butanol‐ethanol ( ABE ) fermentation. Butanol has many superior characteristics compared to other biofuels, such ethanol. However, its production fermentation faces challenges of low productivity and yield because product inhibition heterofermentation, respectively, thereby, high costs. Until date, molecular biological techniques engineering methods have been applied for...
We present a low-complexity fully pilot-based digital signal processing (DSP) chain designed for high spectral efficiency optical transmission systems. study the performance of individual pilot algorithms in simulations before demonstrating 51×24 Gbaud PM-64QAM superchannel over distances reaching 1000 km. an overhead optimization technique using system achievable information rate to find optimal balance between increased and throughput reduction from adding additional DSP pilots. Using...
Recently, two methods have been proposed for regional cerebral blood flow (rCBF) quantitation using [ 123 I]iodoamphetamine (IMP) and single-photon emission computed tomography (SPECT). The table look-up (TLU) method has shown to provide both rCBF volume of distribution, V d , images from SPECT scans, while a single-scan autoradiographic (ARG) technique provided fixed assumed . In methods, single sample was referred calibrate the previously determined standard input function present...
Background: Lipocalin-2/neutrophil gelatinase-B associated lipocalin (Lcn2/NGAL) is involved in the transport of iron and seems to play an important role inflammation. A recent study has reported that it also expressed failing heart may be a biomarker not only for renal failure but failure. Because Lcn2/NGAL thought induced by interleukin-1, might strongly presence myocarditis. Methods Results: This investigated expression rat experimental autoimmune myocarditis (EAM) human In EAM hearts,...
We describe in detail the recently proposed four-dimensional modulation format family based on 2-ary amplitude 8-ary phase-shift keying (2A8PSK), supporting spectral efficiencies of 5, 6, and 7 bits/symbol. These formats nicely fill efficiency gap between dual-polarization (DP) quadrature PSK (QPSK) DP 16-ary quadrature-amplitude (16QAM), with excellent linear nonlinear performance. Since these just use different parity bit expressions same constellation, similar digital signal processing...
The aim of this study was to investigate the relationship between J-wave dynamics and arrhythmias during myocardial ischaemia in patients with vasospastic angina (VSA).Sixty-seven consecutive diagnosed VSA by a provocation test for coronary spasm were grouped according whether they had J wave baseline electrocardiograms or not (VSA-JW group, n = 14; VSA-non-JW group: 53). We retrospectively studied associations ST-segment induced ventricular fibrillations (VFs) spasm. In VSA-JW 7 14 showed...
Abstract Safety, tolerability, pharmacokinetics and efficacy of bexarotene, a novel retinoid X receptor ( RXR )‐selective retinoid, were evaluated in Japanese patients with stage IIB – IVB relapsed/refractory IB IIA cutaneous T‐cell lymphomas CTCL ). This study was conducted as multicenter, open‐label, historically controlled, single‐arm phase I/II study. Bexarotene p.o. administrated once daily at dose 300 mg/m 2 for 24 weeks 13 patients, following an evaluation safety tolerability 4 150...
Introduction: Progressive heart failure and ventricular fibrillation are major causes of death in patients with chronic failure. Mechanical alternans (pulsus alternans) has been observed severe congestive Visible T wave occasionally is a precursor fibrillation. We investigated the occurrence both cardiac 94 Methods Results: Mean left ejection fraction (LVEF) study population was 35 ± 10%. detected pressure during diagnostic catheterization. Only sustained mechanical included study....
Background T-helper (Th)1/Th2 cytokine balance plays an important role in the pathogenesis of myocarditis. Recently, some studies indicate that interleukin (IL)-17, known as a T cell (Th17)-derived proinflammatory cytokine, is major mediator tissue inflammation inflammatory and autoimmune diseases. Experimental myocarditis (EAM) cell-mediated disease; however, pathogenic IL-17 development rat EAM remains largely unknown. Methods Results In present study, alterations IL-17-related protein...
Colorectal cancer (CRC) is one of the most frequently occurring cancers in Japan, and thus a wide range methods have been deployed to study molecular mechanisms CRC. In this study, we performed comprehensive analysis CRC, incorporating copy number aberration gene expression data. For last four years, collecting data from CRC cases organizing information as an "omics" by integrating many kinds into single investigation. our previous studies, had experienced difficulty finding genes related...
High-throughput optical communication systems utilize binary soft-decision forward error correction (SD-FEC) with bit interleaving over the channels. The generalized mutual information (GMI) is an achievable rate (AIR) in such and known to be a good predictor of after SD-FEC decoding (post-FEC BER) for uniform signaling. However, probabilistically shaped (nonuniform) signaling, we find that normalized AIR, defined as AIR divided by signal entropy, less correlated post-FEC BER. We show...
We propose a novel nonlinearity mitigation technique which can double the spectral efficiency of phase-conjugate twin wave by diplexing waves. Simulation shows Q improvement 1.2 dB from conventional DP-QPSK transmission.
We simultaneously measured the concentrations of parathyroid hormone related peptide (PTHrP) and cytokines in synovial fluid (SF) to clarify relationship between PTHrP cytokine network SF elderly patients with arthritis. was collected from knee joints five RA aged 66±11 years old nine osteoarthritis (OA) 80±9 old. by enzyme-linked immunosorbent assay (ELISA), whereas tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6)...
Background— Interleukin-1 (IL-1) is a powerful and important cytokine in myocarditis. The purpose of this study was to evaluate the effect possible mechanism hydrodynamics-based delivery IL-1 receptor antagonist (IL-1RA)-immunoglobulin (Ig) gene for treatment rat experimental autoimmune myocarditis (EAM). Methods Results— On day after immunization, rats were transfected with either pCAGGS encoding IL-1RA-Ig or Ig alone. 17, therapy effective controlling EAM, as monitored by decreased ratio...
Abstract Glycyrrhizin improves the resistance of burn mice to Pseudomonas aeruginosa wound infection through inhibiting IL-10 and/or CCL2 production by Gr-1+ CD11b+ cells. The decreased antimicrobial peptides in tissues surrounding sites has been described patients with severe injury. Small numbers spread easily whole body when infected at site tissues. Gr-1+CD11b+ cells, demonstrated site, are inhibitory on EK. In this paper, EK influenced cells was shown be restored glycyrrhizin. and were...