A5102808320- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Treatment and Pharmacology
- Cardiac Imaging and Diagnostics
- T-cell and B-cell Immunology
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Angiogenesis and VEGF in Cancer
- Coronary Interventions and Diagnostics
- Cardiac tumors and thrombi
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- Cardiac Arrhythmias and Treatments
- Venous Thromboembolism Diagnosis and Management
- Pericarditis and Cardiac Tamponade
- Virus-based gene therapy research
- Chemotherapy-related skin toxicity
Niigata Cancer Center Hospital
2013-2025
Niigata University
2001-2010
Osaka University
2005
Niigata University of Pharmacy and Medical and Life Sciences
2005
Mayo Clinic
2001-2004
National Defense Medical College
1998
Kitasato University
1998
Background The future burden of heart failure in Japan was projected to 2055 order prospectively estimate the number these patients. Methods and Results statistics are based on prevalence data left ventricular dysfunction (LVD) Sado City using Heart Failure Study (2003) population estimates from Japanese National Institute Population Social Security Research Report (2006). outpatients with LVD 979,000 2005, is predicted increase gradually as ages, reaching 1.3 million by 2030. Conclusion...
The expression of coxsackievirus and adenovirus receptor (CAR) was dominant in the brains hearts mice until newborn phase. There is no detailed information concerning relation between CAR development hearts. It also uncertain whether able to be induced adult after cardiac injury. We demonstrated that abundant rats but barely detectable rats. rat with experimental autoimmune myocarditis, which by immunization purified myosin, serially investigated. Active myocarditis observed from day 15...
Abstract IL-22 is one of several cytokines with limited homology to IL-10. However, the biological activities are mostly unknown. The purpose this study was evaluate effect on rat experimental autoimmune myocarditis (EAM) and elucidate an aspect IL-22. Rats were immunized day 0; IL-22-Ig-treated rats injected pCAGGS-IL-22-Ig control pCAGGS-Ig using hydrodynamics-based gene delivery 1 or 6. IL-22-Ig therapy administered 6 after immunization effective in controlling EAM as monitored by heart...
Background —Clinical manifestations of acute myocarditis, with distinct onset, vary from asymptomatic to fatal. The predictors the course disease in patients myocarditis at initial presentation have not yet been established. In this study, we examined predictive values various parameters myocarditis. Methods and Results —Twenty-one consecutive who had diagnosed as having by histological examinations were analyzed. divided into survival group (n=13) fatal (n=8). We clinical state, hemodynamic...
Abstract —Autoimmunity after viral myocarditis is considered to be one of the causes dilated cardiomyopathy. Cytokines are assumed play an important role in pathogenesis. We recently reported that interleukin (IL)-2 and interferon (IFN)-γ mRNA expressed myocardium rats with experimental autoimmune (EAM). However, cytokines myocardial injury detail still not clear. Reverse transcription–polymerase chain reaction identified IL-12 (p40) antigen-presenting cells initial phase EAM. Cardiac...
In 2023, collaboration between cardiologists and oncologists was recommended as part of Japan's Basic Plan to Promote Disease Control Programs for both cancer cardiovascular diseases. This study explores the extent this in Niigata Prefecture. Self-administered questionnaires about immune checkpoint inhibitor-associated myocarditis (ICIAM) anthracycline-related cardiomyopathy (ARCM) were distributed all leading hospitals across Prefecture, whom 124 41 29 responded. Clinical experience with...
SUMMARY Monocyte chemoattractant protein-1 (MCP-1) is a member of the C-C chemokine family that has been shown to play major role in migration monocytes and T cells an inflammatory focus. To clarify MCP-1 pathogenesis myocarditis, we have examined expression rat hearts with experimental autoimmune myocarditis (EAM), also measured serum levels patients histology-proven acute myocarditis. Lewis rats were immunized cardiac myosin killed 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 42 56 days after...
Introduction: Progressive heart failure and ventricular fibrillation are major causes of death in patients with chronic failure. Mechanical alternans (pulsus alternans) has been observed severe congestive Visible T wave occasionally is a precursor fibrillation. We investigated the occurrence both cardiac 94 Methods Results: Mean left ejection fraction (LVEF) study population was 35 ± 10%. detected pressure during diagnostic catheterization. Only sustained mechanical included study....
Background— Interleukin-1 (IL-1) is a powerful and important cytokine in myocarditis. The purpose of this study was to evaluate the effect possible mechanism hydrodynamics-based delivery IL-1 receptor antagonist (IL-1RA)-immunoglobulin (Ig) gene for treatment rat experimental autoimmune myocarditis (EAM). Methods Results— On day after immunization, rats were transfected with either pCAGGS encoding IL-1RA-Ig or Ig alone. 17, therapy effective controlling EAM, as monitored by decreased ratio...
Abstract Background Trastuzumab has improved breast cancer (BC) prognosis and reduced anthracycline use. However, the characteristic changes of anthracycline-related cardiomyopathy (ARCM) in patients with BC remain unclear. We aimed to update our understanding ARCM trastuzumab era. METHODS This retrospective observational cohort study included 2959 treated anthracyclines at three regional centers Niigata City between 1990 2020. Seventy-five (2.5%) developed were categorized into two groups:...
Genetic responses that characterize experimental autoimmune myocarditis (EAM) have not yet been determined. To investigate gene expression in the myocardium of EAM, absolute copy numbers 44 mRNA species [calcium-handling proteins, contractile natriuretic peptides (NPs), cytokines, chemokines, growth factors, renin–angiotensin–aldosterone (RAA) system, endothelins (ETs) and extracellular matrix] synthesized cDNA from a fixed quantity total heart RNA were assessed using real-time...
Background The incidence of diastolic heart failure (DHF) is increasing with the aging community and identifying patients isolated dysfunction (IDD) important for preventing DHF. However, very little information available about such in Japanese community. Methods Results medical all outpatients moderate to severe IDD was extracted from records approximately 6,948 individuals who underwent echocardiographic (Echo) examinations during past 5 years Sado Island. Of 284 extracted, 272 survived...
SUMMARY The mechanisms of progression, remission and relapse myocarditis remain unclear. To clarify these mechanisms, we focused on T helper-1 (Th1)/T helper-2 (Th2) subsets balance peripheral lymphocytes serum cytokine levels during disease progression in rats with experimental autoimmune (EAM). Lewis were immunized cardiac myosin day 0. Blood samples collected days 0, 7, 15, 18, 21, 28, 35, 42, 49 56 following immunization. We examined percentages interferon (IFN)-γ and/or interleukin...
We herein report the histopathology of a rare case an idiopathic internal mammary artery aneurysm in 61-year-old asymptomatic woman. Chest radiography during annual medical check-up incidentally revealed aneurysm, which was initially mistaken for mediastinal tumor. Given that rupture could have been life-threatening, it removed surgically, and found to possess paper-thin arterial wall with cystic medial degeneration.
Background: Although guideline-directed medical therapy (GDMT), including β-blockers, angiotensin-converting enzyme inhibitors (ACEi)/angiotensin receptor blockers (ARBs), and mineralocorticoid antagonists (MRAs), improves survival quality of life, most patients with heart failure reduced (HFrEF) mildly (HFmrEF) ejection fraction are treated inadequate medications. We investigated the prescription patterns GDMT in elderly HFrEF HFmrEF their characteristics, certification long-term care...