A5071253570- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Viral Infections and Immunology Research
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Renal Diseases and Glomerulopathies
- Cardiac Imaging and Diagnostics
- Regional Economic and Spatial Analysis
- Vasculitis and related conditions
- Cardiac Structural Anomalies and Repair
- CAR-T cell therapy research
- Head and Neck Cancer Studies
- Congenital Diaphragmatic Hernia Studies
- Financial Crisis of the 21st Century
- Cardiac Health and Mental Health
- Allergic Rhinitis and Sensitization
- Congenital Heart Disease Studies
- Regional Economics and Spatial Analysis
- Cardiac Ischemia and Reperfusion
- Immunotherapy and Immune Responses
- Asthma and respiratory diseases
- Vascular anomalies and interventions
Showa University
2013-2025
Sendai City Hospital
2015-2024
Gunma University
2021-2024
Tokyo Institute of Technology
2024
Shiga University of Medical Science
2023
Toho University
2013-2023
Tohoku University
2015-2023
Institute of Aging
2023
National Cerebral and Cardiovascular Center
2020-2022
Sado General Hospital
2004-2021
Background The future burden of heart failure in Japan was projected to 2055 order prospectively estimate the number these patients. Methods and Results statistics are based on prevalence data left ventricular dysfunction (LVD) Sado City using Heart Failure Study (2003) population estimates from Japanese National Institute Population Social Security Research Report (2006). outpatients with LVD 979,000 2005, is predicted increase gradually as ages, reaching 1.3 million by 2030. Conclusion...
The epidemiological manifestations of ANCA-associated vasculitis (AAV) differ geographically. However, there have been no prospective studies comparing the incidence AAV between Japan and Europe over same time period using case definitions.The was determined by a population-based method in Miyazaki prefecture, Japan, Norfolk, U.K., 2005 2009. Patients with were defined classified according to European Medicines Agency (EMEA) algorithm.The number incident cases U.K. 86 50, respectively,...
Lysophosphatidylserine (LysoPS) is an endogenous lipid mediator generated by hydrolysis of membrane phospholipid phosphatidylserine. Recent ligand screening orphan G-protein-coupled receptors (GPCRs) identified two LysoPS-specific human GPCRs, namely, P2Y10 (LPS2) and GPR174 (LPS3), which, together with previously reported GPR34 (LPS1), comprise a LysoPS receptor family. Herein, we examined the structure–activity relationships series synthetic analogues toward these recently deorphanized...
CS-0777 (3) is phosphorylated in vivo, and the phosphate of (CS-0777-P) (4) acts as a selective S1P receptor-1 (S1P1) modulator. We report herein synthesis CS-0777-P, pharmacological effects such S1P1 S1P3 agonist activity vitro, peripheral blood lymphocyte lowering suppressive effect on experimental autoimmune encephalomyelitis (EAE), also pharmacokinetics rats. CS-0777-P had ∼320-fold greater for human (EC50; 1.1 nM) relative to 350 nM). Following administration single oral doses 0.1 1...
Recently, laparoscopic percutaneous extraperitoneal closure (LPEC) has gained increased popularity for pediatric inguinal hernia repair. To improve cosmesis, we developed single incision LPEC (SILPEC). The aim of this study was to assess the safety and feasibility SILPEC compared with traditional open repair (OR). This a single-center retrospective cohort 2028 children who underwent between April 2005 August 2014. Nine hundred ninety-five patients OR 1033 SILPEC. Medical records were...
This study aimed to establish a systematic method for diagnosing atrioventricular nodal reentrant tachycardia (AVNRT) with bystander concealed nodoventricular pathway (cNVP).
Severe constipation can cause ischemic bowel disease and other complications in older adults. However, its association with the formation of prostate abscesses has rarely been reported. An 80-year-old male recently presented to our center syncope, dehydration, constipation. Contrast-enhanced computed tomography (CT) revealed fecal impaction a hypodense lesion prostate. Despite no initial elevation inflammatory markers, patient later developed recurrent hypotension. Follow-up CT confirmed...
Abstract In the presence of zinc halide, 2-furyllithium reacts with 2,3-O-isopropylidene-d-glyceraldehyde in a highly stereoselective manner to give chiral and stereo-defined alcohol, 2,2-dimethyl-4-(2-furyl)hydroxymethyl-1,3-dioxolane, which is further elaborated afford d-ribulose three steps.
Fulminant myocarditis with cardiogenic shock requires extracorporeal life support (ECLS) and has poor outcomes. To improve outcomes, we have converted patients severely impaired cardiac multiorgan function from peripheral to central ECLS. In this study, reviewed these patients' clinical outcomes investigated associated factors.We retrospectively studied 70 consecutive fulminant under 2006 2020. Forty-eight underwent surgical conversion support, the remaining continued support. The end point...
To assess the health care burden of elderly patients with heart failure (HF) in an aging Japanese community-based hospital, we investigated outcomes cardiac rehabilitation.We enrolled all HF aged ≥65 years admitted to 3 hospitals Niigata Prefecture. We prospectively collected data on their hospital stays and for 2 postdischarge. The cohort comprised 617 (46.5% men; mean age 84.7 years), 76.2% whom were ≥80 years. Among these patients, 15.6% nursing home residents, 57.7% required long-term...
An essential role of titin as a molecular ruler in sarcomerogenesis has been frequently discussed. In this study, we tested the hypothesis that expression is prerequisite for thick filament incorporation into sarcomeres by using an antisense oligonucleotide approach to interfere with translation de-/redifferentiation model adult rat cardiomyocytes (ARC) long-term culture. As first step, growth pattern ranging from rod shape round and later spreading cells cell surface area ARC were...
Background The incidence of diastolic heart failure (DHF) is increasing with the aging community and identifying patients isolated dysfunction (IDD) important for preventing DHF. However, very little information available about such in Japanese community. Methods Results medical all outpatients moderate to severe IDD was extracted from records approximately 6,948 individuals who underwent echocardiographic (Echo) examinations during past 5 years Sado Island. Of 284 extracted, 272 survived...
Cancer immunotherapy using chimeric antigen receptor–armed T (CAR T) cells have been shown to improve outcomes significantly in patients with hematological malignancies. However, cytokine release syndrome (CRS) remains a risk. CRS is characterized by the excessive activation of CAR and macrophages. Signs symptoms are usually resolved after steroid administration, but steroids abrogate expansion persistence cell populations. Tocilizumab humanized monoclonal antibody (mAb) that attenuates...
Congenital dermoid fistulas of the anterior chest regions (CDFACRs) consist a skin orifice at border sternocleidomastoid muscle with extending caudally in subcutaneous tissue near sternoclavicular joint. We report 2 pediatric CDFACR cases pathognomonic sonography findings. By using sonography, we could diagnose as CDFACRs by focusing on their location and direction reveal distal side for complete resection. suggest that which does not involve radiation or require sedation, is better choice...