Yoshiaki Kaneko
A5023742411- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Receptor Mechanisms and Signaling
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Syncope and Autonomic Disorders
- Sports injuries and prevention
- Congenital Heart Disease Studies
- Electrochemical Analysis and Applications
- ECG Monitoring and Analysis
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Pulmonary Hypertension Research and Treatments
- Cardiac tumors and thrombi
Gunma University
2016-2025
National Defense Medical College Hospital
2024
Doshisha Women's College of Liberal Arts
2024
Gunma University Hospital
2005-2020
Cardiovascular Institute Hospital
2016-2020
National Cerebral and Cardiovascular Center
2014-2017
Nagoya University
2017
Oita University
2017
Keio University
2017
Tachikawa Medical Center
2017
Background: Target anticoagulation levels for warfarin in Japanese patients with non-valvular atrial fibrillation (NVAF) are unclear. Methods and Results: Of 7,527 NVAF, 1,002 did not receive (non-warfarin group), the remaining receiving were divided into 5 groups based on their baseline international normalized ratio (INR) of prothrombin time (≤1.59, 1.6–1.99, 2.0–2.59, 2.6–2.99, ≥3.0). Patients followed-up prospectively 2 years. Primary endpoints thromboembolic events (cerebral infarction,...
AimsAtrial fibrillation (AF) is a common arrhythmia frequently associated with hypertension. This study was designed to test the hypothesis that lowering blood pressure by angiotensin II-receptor blockers (ARB) has more beneficial effects than conventional calcium channel (CCB) on frequency of paroxysmal AF
Background— Electrical storms (ESs) in patients with Brugada syndrome (BrS) are rare though potentially lethal. Methods and Results— We studied 22 men BrS ES, defined as ≥3 episodes/d of ventricular fibrillation (VF) compared their characteristics those 110 age-matched, control without ES. was diagnosed by a spontaneous or drug-induced type 1 pattern on the ECG absence structural heart disease. Early repolarization (ER) J waves, ie, >0.1 mV notches slurs terminal portion QRS complex. The...
Stringent variant interpretation guidelines can lead to high rates of variants uncertain significance (VUS) for genetically heterogeneous disease like long QT syndrome (LQTS) and Brugada (BrS). Quantitative disease-specific customization American College Medical Genetics Genomics/Association Molecular Pathology (ACMG/AMP) address this false negative rate.We compared rare frequencies from 1847 LQTS (KCNQ1/KCNH2/SCN5A) 3335 BrS (SCN5A) cases the International LQTS/BrS Consortia...
The existence of an atypical fast-slow (F/S) atrioventricular nodal reentrant tachycardia (AVNRT) including a superior (sup) pathway with slow conductive properties and atrial exit near the His bundle has not been confirmed.We studied 6 women 2 men (age, 74 ± 7 years) sup-F/S-AVNRT who underwent successful radiofrequency ablation bundle. Programmed ventricular stimulation induced retrograde conduction over SP earliest activation bundle, mean shortest spike-atrial interval 378 119...
To clarify the influence of hypertension and blood pressure (BP) control on thromboembolism major hemorrhage in patients with nonvalvular atrial fibrillation, a post hoc analysis J-RHYTHM Registry was performed.A consecutive series outpatients fibrillation enrolled from 158 institutions. Of 7937 patients, 7406 (70.8% men, 69.8±10.0 years) were followed for 2 years or until an event occurred. Hypertension defined as systolic BP ≥140 mm Hg, diastolic ≥90 history hypertension, and/or...
Genetic testing for long QT syndrome (LQTS) is useful diagnosis, risk stratification, and therapeutic strategies. This study investigated the clinical impact of genetic LQTS patients. Total 3,851 patients (proband: 2,316 [60%]; female: 2,283 [59%]; median age: 14 years [interquartile range 9-36 years]) diagnosed with (LQTS score ≥3.5, QTc ≥500 ms, pathogenic variants in LQTS-associated genes, or unexplored syncope 480-499 ms) were enrolled this study. Of these patients, 1,146 (29.8%)...
This study aimed to establish a systematic method for diagnosing atrioventricular nodal reentrant tachycardia (AVNRT) with bystander concealed nodoventricular pathway (cNVP).
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disorder mostly caused by desmosome gene mutations. Recent comprehensive mutation analyses of Caucasian ARVC patients have revealed the presence not only single heterozygous mutation, but also compound and digenic heterozygosity. However, genetic basis Japanese remains poorly elucidated.The subjects were 7 definite 1 possible probands (6 males, 16-76 years age), their family members. Genetic screening for major...
Background: Brugada syndrome (BrS) is genetically heterogeneous. In Japanese BrS patients, except for SCN5A and KCNE5, mutations in the responsible genes have not yet been identified, therefore genetic heterogeneity remains poorly elucidated. Methods Results: Forty consecutive patients with Brugada-pattern electrocardiogram (ECG) underwent comprehensive analysis of BrS-causing including SCN5A, SCN1B, SCN3B, CACNA1C, CACNB2, KCNE3 KCNE5. Besides identifying 8 present cohort, a T4A mutation...
Recently, new vaccine platforms-including mRNA vaccines for coronavirus disease 2019 (COVID-19) have been given emergency use authorization in Japan. Here, we present a rare case of myocarditis following COVID-19 vaccine. In this case, was confirmed by cardiac magnetic resonance imaging, endomyocardial biopsy, and troponin levels. The degree myocardial inflammation the biopsy samples mild patient's clinical course not severe. Although pathology mild, further investigation would be needed....
Acute myocardial infarction (AMI) induces marked activation of the sympathetic nervous system. Fatty acid binding protein 4 (FABP4) is not only an intracellular protein, but also a secreted adipokine that contributes to obesity-related metabolic complications. Here, we examined role serum FABP4 as pathophysiological marker in patients with AMI.We studied 106 presenting emergency unit final diagnosis AMI, including 12 resuscitated from out-of-hospital cardiac arrest (OHCA) caused by...
Background— To know the underlying mechanisms of J waves, response to atrial pacing was studied in patients with idiopathic ventricular fibrillation (IVF) and non-IVF. Methods Results— In 8 IVF, J-wave amplitude measured before, during, after pacing. All had episodes without structural heart disease. The responses waves were compared those 17 non-IVF control subjects who revealed but no history cardiac arrest underwent electrophysiological study. IVF younger than (28±10 versus 52±14 years,...
Mutations in SCN5A are linked to Brugada syndrome approximately 20% of all cases (BrS1). Several dozen distinct mutations BrS1 have been associated with the increased risk cardiac arrhythmias. However, genotype-phenotype relationship remains elusive. The current study analyzed gene elucidate potential variability clinical features Japanese subjects. Subjects present included 30 probands (25 male subjects, 45 ± 15 years age) Brugada-pattern ECG. Seven patients had resuscitated from...
Background: Clinical characteristics, including risk factors for thromboembolism, and medications differ between men women with atrial fibrillation (AF) in Western countries. Whether such a difference exists Japanese patients AF is unclear, so data from J-TRACE were used to investigate this issue. Methods Results: A total of 2,892 (2,028 men, 864 women; 70.3 years old) analyzed the respective prevalences medications. CHADS2 score was calculated determine thromboembolic level. Women older...