A5077724157- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Vascular anomalies and interventions
- Neurological disorders and treatments
- Sarcoidosis and Beryllium Toxicity Research
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Receptor Mechanisms and Signaling
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Respiratory and Cough-Related Research
- Vitamin D Research Studies
- Cardiovascular Issues in Pregnancy
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Salivary Gland Disorders and Functions
The University of Tokyo
2006-2025
National Cerebral and Cardiovascular Center
2011-2024
University of Tokyo Hospital
2015-2024
University of Rochester Medical Center
2019
Institute of Clinical and Experimental Medicine
2015-2018
Niigata University
2017
Shiga University of Medical Science
2017
Keio University
2017
Nippon Medical School
2017
Tokyo University of Science
2012-2016
Background: The genotype-phenotype correlation of SCN5A mutations as a predictor cardiac events in Brugada syndrome remains controversial. We aimed to establish registry limited probands, with long follow-up period, so that the can be examined without patient selection bias. Methods: This multicenter enrolled 415 probands (n=403; men, 97%; age, 46±14 years) diagnosed whose gene was analyzed for mutations. Results: During mean period 72 months, overall event rate 2.5%/y. In comparison ( (–),...
Abstract Aims The prognostic value of genetic variants for predicting lethal arrhythmic events (LAEs) in Brugada syndrome (BrS) remains controversial. We investigated whether the functional curation SCN5A variations improves predictability. Methods and results Using a heterologous expression system whole-cell patch clamping, we functionally characterized 22 unknown significance (VUSs) among 55 mutations previously curated using silico prediction algorithms Japanese BrS registry (n = 415)....
Complications of catheter ablation for atrial fibrillation (AF) are frequently related to vascular access. We hypothesized that ultrasound-guided (USG) venipuncture may facilitate the procedure and reduce complication rates.We conducted a multicentre, randomized trial in patients undergoing AF on uninterrupted anticoagulation therapy. The study enrolled consecutive 320 (age: 63 ± 8 years; male: 62%) were USG or conventional 1:1 fashion. It was prematurely terminated due substantially...
Stringent variant interpretation guidelines can lead to high rates of variants uncertain significance (VUS) for genetically heterogeneous disease like long QT syndrome (LQTS) and Brugada (BrS). Quantitative disease-specific customization American College Medical Genetics Genomics/Association Molecular Pathology (ACMG/AMP) address this false negative rate.We compared rare frequencies from 1847 LQTS (KCNQ1/KCNH2/SCN5A) 3335 BrS (SCN5A) cases the International LQTS/BrS Consortia...
Sarcoidosis is a systemic infiltrative disease characterized by non-caseating granuloma formation, and its cardiac phenotype an important prognostic factor.1 affecting the heart without extracardiac involvement termed isolated sarcoidosis (CS). Isolated CS was once thought to be rare manifestation of because diagnostic challenge arising from low sensitivity endomyocardial biopsy (EMB).2 Considering that importance early diagnosis treatment are critical in managing CS,3 Japanese Circulation...
25-Hydroxyvitamin D3 [25(OH)D3] is the best-established indicator of vitamin D status. 4-Phenyl-1,2,4-triazoline-3,5-dione (PTAD), a representative Cookson-type reagent, has often been employed for enhancing sensitivity in trace determination 25(OH)D3 neonatal dried blood spot (DBS), which contains only 2.65 μL whole blood, using liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS). The objective this study was development novel reagent surpassing PTAD terms...
Background Aging is one of the major concerns and determinants indications for catheter ablation (CA) atrial fibrillation. This study aimed to assess safety CA in older patients with fibrillation undergoing CA. Methods Results The JROAD-DPC (Japanese Registry All Cardiac Vascular Diseases-Diagnosis Procedure Combination) a nationwide claims database using data from Japanese Diagnosis Combination/Per Diem Payment System. Among 6 632 484 records found between April 2012 March 2018 1058...
Background: Pulmonary vein isolation (PVI) is a cornerstone of catheter ablation in patients with paroxysmal atrial fibrillation, and balloon-based has been recently performed worldwide. The second-generation cryoballoon (CB2) proven to be highly effective achieving freedom from fibrillation. However, there are some debatable questions, including the ideal number freeze cycles. Methods: AD-Balloon study (Multicenter Study Validity Additional Freeze Cycles for Cryoballoon Ablation) was...
Human cardiac ryanodine receptor 2 (RYR2) shows autosomal-dominant inheritance in catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1); however, de novo variants have been observed sporadic cases. Here, we investigated CPVT1-related RYR2 variant and its clinical significance between familial We enrolled 82 independent CPVT1 probands (median age: 10.0 (7.0-13.0) years; 45 male) carrying the whose biological origin could be confirmed by parental genetic analysis: assured...
There are few data to compare the long-term efficacy of sirolimus-eluting stent (SES) and off-pump coronary artery bypass grafting (OPCAB) for diabetic patients with multivessel disease (MVD).In a single-center non-randomized registry, 208 MVD were examined (SES group: n=92, OPCAB n=116). The occurrence major adverse cardiac cerebrovascular events (MACCE, defined as all-cause death, non-fatal myocardial infarction, event, repeat revascularization) was compared between 2 groups. Fasting blood...
<h3>Importance</h3> Long QT syndrome (LQTS) is caused by several ion channel genes, yet risk of arrhythmic events not determined solely the responsible gene pathogenic variants. Female sex after adolescence associated with a higher in individuals congenital LQTS, but association between and genotype-based LQTS still unclear. <h3>Objective</h3> To examine location LQTS-related variant as it pertains to life-threatening arrhythmias. <h3>Design, Setting, Participants</h3> This retrospective...
Radiofrequency catheter ablation has become the treatment of choice for atrial fibrillation (AF) that does not respond to antiarrhythmic drug therapy. During procedure, fluoroscopy imaging is still considered essential visualise catheters in real-time. However, radiation often ignored by physicians since it invisible and long-term risks are underestimated. In this respect, must be emphasised exposure various potentially harmful effects, such as acute skin injury, malignancies genetic...
Abstract Background Predicting the origin of premature ventricular contraction (PVC) from preoperative electrocardiogram (ECG) is important for catheter ablation therapies. We propose an explainable method that localizes PVC based on semantic segmentation result a 12‐lead ECG using deep neural network, considering suitable diagnosis support clinical application. Methods The learning‐based model was trained 265 recordings 84 patients with frequent PVCs. classified each sampling time into four...
Background Epicardial mapping can reveal low‐voltage areas on the right ventricular outflow tract in patients with Brugada syndrome several fibrillation ( VF ) episodes. A type 1 ECG is associated an abnormal electrogram epicardium. This study investigated clinical significance of amplitude ECGs syndrome. Methods and Results In 209 a spontaneous (26 resuscitated from , 54 syncope, 129 asymptomatic), leads exhibiting was measured among V1 to V3 positioned standard upper 2 intercostal spaces....
Abstract Introduction Infection is one of the most important complications associated with cardiac implantable electronic device (CIED) therapy. The number reports comparing outcomes transvenous lead extraction (TLE), surgical extraction, and conservative treatment for CIED infections using a real‐world database limited. This study investigated association between strategies their outcomes. Methods We performed retrospective analysis 3605 patients admitted to 681 hospitals nationwide...