A5063344371- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- ECG Monitoring and Analysis
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiac pacing and defibrillation studies
- Receptor Mechanisms and Signaling
- Cardiomyopathy and Myosin Studies
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Effects of Exercise
- Atrial Fibrillation Management and Outcomes
- Genetic Associations and Epidemiology
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Cardiac Arrest and Resuscitation
- Ion Transport and Channel Regulation
- Veterinary Equine Medical Research
- Thyroid Disorders and Treatments
- Complex Systems and Time Series Analysis
- Metabolism and Genetic Disorders
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Psoriasis: Treatment and Pathogenesis
- Neuroscience and Neuropharmacology Research
University of Copenhagen
2016-2025
University of California, San Francisco
2023-2024
Foundation Center
2008-2024
Novo Nordisk Foundation
2017-2024
Novo Nordisk Foundation Center for Basic Metabolic Research
2017-2024
University of California System
2024
Physiol (Belgium)
2024
Massachusetts General Hospital
2021
Gentofte Hospital
2009-2021
University of Florida
2019
The Brugada Syndrome (BrS), an inherited syndrome associated with a high incidence of sudden cardiac arrest, has been linked to mutations in four different genes leading loss function sodium and calcium channel activity. Although the transient outward current (I(to)) is thought play prominent role expression syndrome, I(to)-related have not identified as yet.One hundred five probands BrS were screened for ion gene using single strand conformation polymorphism (SSCP) electrophoresis direct...
Risk stratification in patients with type 3 long-QT syndrome (LQT3) by clinical and genetic characteristics effectiveness of β-blocker therapy has not been studied previously a large LQT3 population.The study population included 406 51 sodium channel mutations; 391 were known to be event free during the first year life focus our study. Clinical, electrocardiographic, parameters acquired for from 7 participating registries. Cox regression analysis was used evaluate independent contribution...
β-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to β-adrenergic and clinical β-blocker therapy according mutation location.The study sample comprised 860 patients with genetically confirmed mutations KCNQ1 channel. Patients were categorized into carriers of missense located cytoplasmic loops (C loops), membrane-spanning domain, C/N terminus, nonmissense mutations. There 27...
Calculation of approximate entropy (ApEn) requires a priori determination two unknown parameters, m and r. While the recommended values r, in range 0.1-0.2 times standard deviation signal, have been shown to be applicable for wide variety signals, certain cases, r within this prescribed can lead an incorrect assessment complexity given signal. To circumvent limitation, we recently advocated finding maximum ApEn value by assessing all from 0 1, found that does not always occur values. Our...
Abstract Recent global developments underscore the prominent role big data have in modern medical science. But privacy issues constitute a prevalent problem for collecting and sharing between researchers. However, synthetic generated to represent real carrying similar information distribution may alleviate issue. In this study, we present generative adversarial networks (GANs) capable of generating realistic DeepFake 10-s 12-lead electrocardiograms (ECGs). We developed compared two methods,...
Treatment with some types of antidepressants has been associated sudden cardiac death. It is unknown whether the increased risk due to a class effect or related specific within drug classes. All patients in Denmark an out-of-hospital arrest (OHCA) were identified (2001–2007). Association between treatment and OHCA was examined by conditional logistic regression case–time–control models. We 19,110 OHCA; 2,913 (15.2%) receiving antidepressant at time OHCA, citalopram being most frequently used...
Stringent variant interpretation guidelines can lead to high rates of variants uncertain significance (VUS) for genetically heterogeneous disease like long QT syndrome (LQTS) and Brugada (BrS). Quantitative disease-specific customization American College Medical Genetics Genomics/Association Molecular Pathology (ACMG/AMP) address this false negative rate.We compared rare frequencies from 1847 LQTS (KCNQ1/KCNH2/SCN5A) 3335 BrS (SCN5A) cases the International LQTS/BrS Consortia...
Abstract Deep learning-based tools may annotate and interpret medical data more quickly, consistently, accurately than doctors. However, as doctors are ultimately responsible for clinical decision-making, any deep prediction should be accompanied by an explanation that a human can understand. We present approach called electrocardiogram gradient class activation map (ECGradCAM), which is used to generate attention maps explain the reasoning behind decision-making in ECG analysis. Attention...
Machine learning (ML) methods for the analysis of electrocardiography (ECG) data are gaining importance, substantially supported by release large public datasets. However, these current datasets miss important derived descriptors such as ECG features that have been devised in past hundred years and still form basis most automatic algorithms critical cardiologists' decision processes. available from sophisticated commercial software but not accessible to general public. To alleviate this...
Nonlinear Dynamics in Heart Rate. Introduction: The term chaos is used to describe erratic or apparently random time‐dependent behavior deterministic systems. It has been suggested that the variability observed normal heart rate may be due chaos, hut this question not settled. Methods and Results: was assessed by recordings of consecutive RR intervals ten healthy subjects using ambulatory ECG. All were performed with at rest supine position. To test for presence nonlinearities und/or chaotic...
Patients with untreated heart failure (HF) exhibit a blunted hemodynamic and neuroendocrine response to high sodium intake, leading excessive water retention. However, it is not known whether this the case for patients compensated HF receiving angiotensin-converting enzyme inhibitors β-adrenoreceptor blockers. Therefore, we determined responses 1 wk of low-sodium diet (70 mmol/day) high-sodium (250 in 12 age-matched controls randomized, balanced fashion. During steady-state conditions,...
Patients with loss-of-function mutations in KCNQ1 have long QT syndrome (LQTS). encodes a voltage-gated K(+) channel located both cardiomyocytes and pancreatic β-cells. Inhibition of β-cells increases insulin secretion. Therefore LQTS patients may exhibit increased Fourteen patients, from six families, diagnosed were individually matched to two randomly chosen BMI-, age-, sex-matched control participants underwent an oral glucose tolerance test (OGTT), hypoglycemia questionnaire, continuous...
AimsWe studied whether variants previously associated with congenital long QT syndrome (cLQTS) have an effect on the QTc interval in a Danish population sample. Furthermore, we assessed carriers of cLQTS-associated genes are more prone to experience syncope compared non-carriers and increased mortality non-carriers.
Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into function. However, the variants identified fall predominantly in non-coding regions their underlying mechanisms remain unclear. Here, we identify putative functional coding variation changes interval duration by combining Illumina HumanExome BeadChip genotype data from 77,898 participants of European...
To investigate the effect of diabetes duration on glycaemic control, measured using mean glycated haemoglobin (HbA1c) level, and mortality risk within different age, sex clinically relevant, comorbidity-defined subgroups in an elderly population with type 2 (T2D).We studied older (≥65 years) primary care patients T2D, who had three successive annual measurements HbA1c taken between 2005 2013. The exposure was all measurements. Follow-up began date third measurement. Individual levels were...
We aimed to study whether visit-to-visit variability of glycated hemoglobin A1c (HbA1c) is associated with incident major adverse cardiovascular events (MACE), all-cause mortality, and type 2 diabetes in people without diabetes.We included primary care patients no history or disease three annual HbA1c measurements within normal range (<6.5% [48 mmol/mol]). For each individual, we measured the as SD residuals obtained from a linear regression on measurements. From regression, also estimated...