A5078194623- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Ion channel regulation and function
- ECG Monitoring and Analysis
- Neurological disorders and treatments
- Cardiovascular Effects of Exercise
- Receptor Mechanisms and Signaling
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Medical History and Research
- Cardiovascular Issues in Pregnancy
- Cardiac Imaging and Diagnostics
- Sympathectomy and Hyperhidrosis Treatments
- Polish Historical and Cultural Studies
- Cardiovascular Syncope and Autonomic Disorders
- Language and Culture
- Polish Legal and Social Issues
- Viral Infections and Immunology Research
- Health, Work, and Social Studies in Poland
University of Rochester
2015-2025
Cardiovascular Research Center
2021-2025
University of Rochester Medical Center
2015-2024
Cleveland Clinic
2022
University of Chicago Medical Center
2021
University of Calgary
2018
Sheba Medical Center
2016
Tel Aviv University
2016
Gentofte Hospital
2016
Amsterdam UMC Location University of Amsterdam
2016
The Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) showed that early intervention cardiac-resynchronization therapy a defibrillator (CRT-D) in patients an electrocardiographic pattern showing left bundle-branch block was associated significant reduction heart-failure events over median follow-up of 2.4 years, as compared alone.We evaluated the effect CRT-D on long-term survival MADIT-CRT population. Post-trial period 5.6 years...
AimsIt has been proposed that competitive sport increases the risk of ventricular tachyarrhythmias (VTA) and death in patients with arrhythmogenic right-ventricular cardiomyopathy (ARVC).However, it is unknown whether this only applies to or if recreational sports activity also VTA/death. Methods resultsProbands diagnosed ARVC according 2010 task force criteria for (n ¼ 108) were included current analysis.At time enrolment, study participants questioned about exercise level prior after...
Risk stratification in patients with type 3 long-QT syndrome (LQT3) by clinical and genetic characteristics effectiveness of β-blocker therapy has not been studied previously a large LQT3 population.The study population included 406 51 sodium channel mutations; 391 were known to be event free during the first year life focus our study. Clinical, electrocardiographic, parameters acquired for from 7 participating registries. Cox regression analysis was used evaluate independent contribution...
The benefit of prophylactic implantable cardioverter-defibrillator (ICD) is not uniform due to differences in the risk life-threatening ventricular tachycardia (VT)/ventricular fibrillation (VF) and non-arrhythmic mortality. We aimed develop an ICD prediction score that integrates competing risks.
Risk of Mortality for Ventricular Arrhythmia . Background: There are limited data regarding the incidence and prognostic significance ventricular arrhythmias (VA) in ambulatory continuous flow left assist device (LVAD) patients. Methods: Sixty‐one consecutive patients from November 1, 2006 through December 31, 2010 with an LVAD implantable cardioverter defibrillator that survived to discharge implantation admission were studied. Follow‐up began date both devices situ ended death, transplant,...
QRS fragmentation (fQRS) has been reported as a useful ECG parameter in predicting mortality high-risk postinfarction patients. Its prognostic value for sudden cardiac death (SCD) and ventricular arrhythmias ischemic cardiomyopathy (ICM) remains unknown.MADIT II enrollment 12-lead ECGs were analyzed fQRS defined RSR' patterns (≥1 R' or notching of S R wave) patients with normal duration >2 notches on the wave abnormal duration, present 2 contiguous leads. Exclusion criteria included paced...
Ventricular tachycardia (VT) and ventricular fibrillation (VF) remain a challenging problem in patients with implantable cardioverter-defibrillators (ICDs).This study aimed to determine whether ranolazine administration decreases the likelihood of VT, VF, or death an ICD.This was double-blind, placebo-controlled clinical trial which high-risk ICD ischemic nonischemic cardiomyopathy were randomized 1,000 mg twice day placebo. The primary endpoint VT VF requiring appropriate therapy death,...
The aim of the present study was to assess a possible association between myocardial substrate, implantable cardioverter defibrillator (ICD) shocks, and subsequent mortality. Within multicentre automatic implantation trial-cardiac resynchronization therapy (MADIT-CRT) population (n = 1790), we investigated ICD shocks mortality using multivariate Cox regression analyses landmark at 1-year follow-up. 4-year cumulative probability 13% for appropriate shock 6% inappropriate shock. Compared with...
Sex Differences in VT/VF or Death MADIT‐CRT Introduction Studies suggest that women with ischemic heart disease are less likely to experience appropriate ICD therapies for ventricular arrhythmias (VT/VF). We evaluated the influence of sex on arrhythmic events death subjects enrolled MADIT‐CRT. Methods and Results Arrhythmic event rates, defined as treated defibrillator therapy all‐cause death, were determined among 1,790 documented 3‐year follow‐up. Predictors VT/VF/death identified using...
Background: Long QT syndrome (LQTS) is caused by the abnormal function of ion channels, which may also affect atrial electrophysiology and be associated with risk fibrillation (AF). However, large-scale studies AF among patients LQTS its relation to manifestations are lacking. We aimed assess relationship genotype long-term prognosis in LQTS. Methods: Genotype-positive (784 LQT1, 746 LQT2, 233 LQT3) were compared 2043 genotype-negative family members. Information on occurrence was based...
Background Implantable cardioverter defibrillator (ICD)‐delivered shocks can cause substantial distress, warranting consideration of ICD deactivation at end life. This study was designed to describe the patterns end‐of‐life management in patients with ICDs. Methods There a retrospective chart review 98 who died arm multicenter automated implantation trial II (MADIT II). The pattern and frequency delivered before death were reviewed. Results We identified three groups: Group 1 consisting...
Background Previous studies have shown conflicting results regarding the benefit of cardiac resynchronization therapy ( CRT ) by sex and QRS duration. Methods Results In Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy MADIT ‐ ), we evaluated long‐term clinical outcome heart failure HF or death, alone duration (dichotomized at 150 ms) in left bundle‐branch block patients with defibrillator backup ‐D) versus implantable cardioverter‐defibrillator...
Sex differences in clinical presentation and outcomes of hereditary arrhythmias are commonly reported. We aimed to compare men women with arrhythmogenic right ventricular cardiomyopathy (ARVC) enrolled the North American ARVC Registry.A total 125 probands (55 females, mean age 38 ± 12; 70 males, 41 15) diagnosed, as either "affected" or "borderline" were included. Baseline characteristics time-dependent including syncope, tachycardia (VT), fast VT (>240 bpm), fibrillation (VF), death...
Current data on efficacy, safety and impact clinical outcome of single- versus dual-coil implantable cardioverter-defibrillator (ICD) leads are limited contradictory.Defibrillation threshold (DFT) at implantation first shock efficacy were compared in patients implanted with ICD MADIT-CRT. The risk for atrial tachyarrhythmias all-cause mortality evaluated. Short- (< 30 days after the implantation) long-term (throughout entire study duration) complications assessed.Patients had significantly...
Background A comprehensive report on the clinical course of three major genotypes long QT syndrome ( LQTS ) in a large U.S. patient cohort is lacking. Methods Our study consisted 1,923 subjects from Rochester‐based Registry with genotype‐positive LQT 1 n = 879), 2 807), and 3 237). We evaluated risk first cardiac event (syncope, aborted arrest, or sudden death, whichever occurred first) birth through age 50 years. Cox proportional hazards regression models incorporating covariates were used...
As questions remain about the risk–benefit of left ventricular assist device (LVAD) therapy, we evaluated association between LVAD versus medical therapy for competing risk all-cause mortality and readmission. Among consecutive patients advanced heart failure (HF) 260 were referred implantation 292 continued in this retrospective, observational database study. At 2 years, was significantly higher among medically managed recipients (37% vs. 25%, p = 0.014). Separation event rates appeared...