A5049428629- Systemic Lupus Erythematosus Research
- Pharmacological Effects of Natural Compounds
- Gout, Hyperuricemia, Uric Acid
- Traditional Chinese Medicine Studies
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Ginseng Biological Effects and Applications
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Traditional Chinese Medicine Analysis
- Immune Response and Inflammation
- Drug-Induced Hepatotoxicity and Protection
- Natural Compounds in Disease Treatment
- Clinical practice guidelines implementation
- Gut microbiota and health
- Hepatitis C virus research
- Urban Transport and Accessibility
- COVID-19 Clinical Research Studies
Zhejiang Chinese Medical University
2016-2025
Sichuan University
2024-2025
West China Hospital of Sichuan University
2024-2025
Southwest Medical University
2024-2025
University of Louisville
2024
Jiangmen Central Hospital
2024
Ningbo University
2023
China Academy of Chinese Medical Sciences
2022
Boston University
1997-2018
Framingham Heart Study
2018
Systemic lupus erythematosus (SLE) in patients from Spain is associated with intestinal dysbiosis. This study explores whether the alteration of gut microbiome SLE China consistent dysbiosis Spain.The depletion Firmicutes and enrichment Bacteroidetes were Spain. Furthermore, we found that nine genera microbiota SLE-related microorganisms Chinese subjects. Genera Rhodococcus, Eggerthella, Klebsiella, Prevotella, Eubacterium, Flavonifractor Incertae sedis significantly enriched, while...
This study employed microbiome and metabolome analysis to explore the fecal signatures of gout patients. Fecal samples from 52 male individuals (26 healthy controls 26 patients) were analyzed by 1H NMR spectroscopy Illumina Miseq sequencing. The showed being up-regulation opportunistic pathogens, such as Bacteroides, Porphyromonadaceae Rhodococcus, Erysipelatoclostridium Anaerolineaceae. some altered metabolites which may involve uric acid excretion, purine metabolism, inflammatory...
Abstract Systemic lupus erythematosus (SLE), a severe autoimmune disorder, is characterized by systemic inflammatory response, autoantibody accumulation and damage to organs. The dysregulation of double-negative (DN) T cells considered as crucial commander during SLE. Neddylation, significant type protein post-translational modification (PTM), has been well-proved regulate cell-mediated immune response. However, the function neddylation in SLE still unknown. Here, we reported that...
Tripterygium wilfordii Hook.f and hypoglaucum (H.Lév.) Hutch is effective herbs to prevent aggravation of Rheumatoid arthritis (RA). However, both them show severe side effects in the reproductive system other systems. Kunxian Capsule (KX), a Traditional Chinese Medicine (TCM) patent prescription, comprised 4 herbs, including H.Lév. Hutch, reported be an available prescription treating RA with fewer as compares tablets. To reveal pharmacological mechanism KX treatment effect alleviation, we...
Qu-zhuo-tong-bi decoction (QZTBD) is a traditional Chinese medicine prescription used to treat hyperuricemia and gout with no obvious adverse effects. However, the mechanism by which QZTBD treats has not been fully explored. Here, we investigated effects of on gouty arthritis its therapeutic from perspective gut microbiome. Our results demonstrated that was effective for reducing serum uric acid level attenuating paw edema mechanical allodynia. promoted abundance butyrate-producing bacteria...
Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into function. However, the variants identified fall predominantly in non-coding regions their underlying mechanisms remain unclear. Here, we identify putative functional coding variation changes interval duration by combining Illumina HumanExome BeadChip genotype data from 77,898 participants of European...
Abstract Atrial fibrillation (AF) is the most common cardiac arrhythmia, but little known about molecular mechanisms associated with AF arrhythmogenesis. DNA methylation an important epigenetic mechanism that regulates gene expression and downstream biological processes. We hypothesize might play role in susceptibility to develop AF. A total of 2,639 participants from Offspring Cohort Framingham Heart Study were enrolled current study. These included 183 prevalent 220 incident during up 9...
Lupus nephritis (LN) is an inflammatory renal disease of patients with systemic lupus erythematosus lots immune complexes deposited in kidneys. Accumulated studies have demonstrated the close relationships among dyslipidaemia, inflammation, and autoimmune response, oxidative stress patients. Lipids play numerous important roles biological process cellular functions. Herein, shotgun lipidomics was employed to quantitatively analyze lipidomes tissue MRL/lpr mice progression LN (including...
Abstract Objective This meta-analysis aims to explore the potential link between vaccines and systemic lupus erythematosus (SLE). Methods We systematically searched PubMed, Cochrane Library, Embase for observational studies from inception September 3, 2023, using medical subject headings (MeSH) keywords. Study quality was assessed NOS scale. Statistical analyses were conducted STATA software (version 14.0). Publication bias evaluated funnel plots Egger’s regression. Results The incorporated...
Resting heart rate is a heritable trait, and an increase in associated with increased mortality risk. Genome-wide association study analyses have found loci resting rate, at the time of our these explained 0.9% variation. This aims to discover new genetic from Exome Chip meta-analyses.Heart was measured either elecrtrocardiograms or pulse recordings. We meta-analysed results 104 452 European-ancestry individuals 30 cohorts, genotyped using Chip. Twenty-four variants were selected for...
Contents Synaptonemal complex protein 3 (SYCP3) is a DNA‐binding located on the lateral elements of synaptonemal complex. This plays an important role in homologous chromosome pairing and necessary for male meiosis spermatogenesis. To further understand SYCP3 gene function its relationship to cattle‐yak sterility, we investigated characteristics bovine ( bSYCP3 ) as well transcription level epigenetic modification status. The encodes 225‐amino acid with Cor1 motif two coiled‐coil‐forming...
Adipose tissue plays an important role in energy metabolism and related diseases.The content of intramuscular fat significantly influences the pork quality.In this study, whole gene expression dorsal subcutaneous (s.c.) adipose (i.m.) isolated from longissimus dorsi muscle were compared using Affymetrix Gene-Chip microarray technology.The result revealed that 1228 genes more highly expressed s.c.adipose tissue, whereas 965 higher i.m. tissue.We found had a stronger capacity lipid fatty acid...