A5039766174- Systemic Lupus Erythematosus Research
- Pharmacological Effects of Natural Compounds
- Wound Healing and Treatments
- interferon and immune responses
- Rheumatoid Arthritis Research and Therapies
- Tissue Engineering and Regenerative Medicine
- Sphingolipid Metabolism and Signaling
- Inflammasome and immune disorders
- Gut microbiota and health
- Muscle Physiology and Disorders
- Spondyloarthritis Studies and Treatments
- Immune Cell Function and Interaction
- Cellular Mechanics and Interactions
- Autoimmune and Inflammatory Disorders Research
- Gout, Hyperuricemia, Uric Acid
- Electrospun Nanofibers in Biomedical Applications
- Atherosclerosis and Cardiovascular Diseases
- Axon Guidance and Neuronal Signaling
- Ubiquitin and proteasome pathways
- Metabolomics and Mass Spectrometry Studies
- Nerve injury and regeneration
- Biomedical Research and Pathophysiology
- Acute Kidney Injury Research
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
Zhejiang Chinese Medical University
2015-2024
The Ohio State University
2015-2024
Hangzhou Medical College
2022-2024
Zhejiang Provincial People's Hospital
2022-2024
Lung Institute
2013-2022
Qingdao University of Science and Technology
2021-2022
Handan College
2022
The Ohio State University Wexner Medical Center
2014-2020
Sutter Davis Hospital
2019
Northeastern University
2019
The assessment and characterization of the gut microbiome has become a focus research in area human autoimmune diseases. Ankylosing spondylitis is an inflammatory disease evidence showed that ankylosing may be microbiome-driven disease. To investigate relationship between spondylitis, quantitative metagenomics study based on deep shotgun sequencing was performed, using microbial DNA from 211 Chinese individuals. A total 23,709 genes 12 metagenomic species were shown to differentially...
Systemic lupus erythematosus (SLE) in patients from Spain is associated with intestinal dysbiosis. This study explores whether the alteration of gut microbiome SLE China consistent dysbiosis Spain.The depletion Firmicutes and enrichment Bacteroidetes were Spain. Furthermore, we found that nine genera microbiota SLE-related microorganisms Chinese subjects. Genera Rhodococcus, Eggerthella, Klebsiella, Prevotella, Eubacterium, Flavonifractor Incertae sedis significantly enriched, while...
This study employed microbiome and metabolome analysis to explore the fecal signatures of gout patients. Fecal samples from 52 male individuals (26 healthy controls 26 patients) were analyzed by 1H NMR spectroscopy Illumina Miseq sequencing. The showed being up-regulation opportunistic pathogens, such as Bacteroides, Porphyromonadaceae Rhodococcus, Erysipelatoclostridium Anaerolineaceae. some altered metabolites which may involve uric acid excretion, purine metabolism, inflammatory...
In the developing vertebrate retina, progenitor cells initially proliferate but begin to produce postmitotic neurons when neuronal differentiation occurs. However, mechanism that determines whether retinal continue or exit from cell cycle and differentiate is largely unknown. Here, we report histone deacetylase 1 (Hdac1) required for switch proliferation in zebrafish retina. We isolated a mutant, ascending descending (add), which fail into glial instead proliferate. The cloning of add gene...
Biopolymeric hydrogels have drawn increasing research interest in biomaterials due to their tunable physical and chemical properties for both creating bioactive cellular microenvironment serving as sustainable therapeutic reagents. Inspired by a naturally occurring hydrogel secreted from the carnivorous Sundew plant trapping insects, here we developed bioinspired deliver mitsugumin 53 (MG53), an important protein cell membrane repair, chronic wound healing. Both compositions...
Oxygen deficiency after myocardial infarction (MI) leads to massive cardiac cell death. Protection of cells and promotion repair are key therapeutic goals. These goals may be achieved by re-introducing oxygen into the infarcted area. Yet current systemic delivery approaches cannot efficiently diffuse area that has extremely low blood flow. In this work, we developed a new system can delivered specifically tissue, continuously release protect cells. The was based on thermosensitive,...
Recombinant MG53 translocates to sites of injury in the proximal tubule kidney and protects mice from acute induced by ischemia or drugs.
Hyperuricaemia is an important risk factor for many diseases including gout, hypertension, and type II diabetes. The gut microbiota associated with hyperuricaemia has also been demonstrated to play significant roles in the effects of drug therapy. This study used Illumina MiSeq sequencing explore alterations microbiome allopurinol benzbromarone treatment male rat hyperuricaemia. After treatment, both caused increase genera Bifidobacterium Collinsella a decrease Adlercreutzia Anaerostipes. In...
Following myocardial infarction (MI), degradation of extracellular matrix (ECM) by upregulated metalloproteinases (MMPs) especially MMP-2 decreases tissue mechanical properties, leading to cardiac function deterioration. Attenuation ECM at the early stage MI has potential preserve resulting in increase. Yet strategy for efficiently preventing remains be established. Current preclinical approaches have shown limited efficacy because low drug dosage allocated heart tissue, dose-limiting side...
MG53 is a muscle-specific TRIM-family protein that presides over the cell membrane repair response. Here, we show present in blood circulation acts as myokine to facilitate tissue injury-repair and regeneration. Transgenic mice with sustained elevation of bloodstream (tPA-MG53) have healthier longer life-span when compared littermate wild type mice. The tPA-MG53 normal glucose handling insulin signaling skeletal muscle, does not deleterious impact on db/db More importantly, display...
Abstract TRIM family proteins play integral roles in the innate immune response to virus infection. MG53 (TRIM72) is essential for cell membrane repair and believed be a muscle-specific protein. Here we show human macrophages express MG53, protein expression reduced following Knockdown of leads increases type I interferon (IFN) upon knockout mice infected with influenza comparable titres wild mice, but display increased morbidity accompanied by more accumulation CD45+ cells elevation IFNβ...
Cancer cells develop resistance to chemotherapeutic intervention by excessive formation of stress granules (SGs), which are modulated an oncogenic protein G3BP2. Selective control G3BP2/SG signaling is a potential means treat non-small cell lung cancer (NSCLC).Co-immunoprecipitation was conducted identify the interaction MG53 and Immunohistochemistry live imaging were performed visualize subcellular expression or co-localization. We used shRNA knock-down G3BP2 test migration colony...
Abstract Background Growing evidences indicate that the alterations in gut microbiota are associated with efficacy of glucocorticoids (GCs) treatment systemic lupus erythematosus (SLE). However, there is no evidence to prove whether directly mediates effects GCs. Methods Using MRL/lpr mice, this study firstly addressed three doses prednisone on microbiota. Then, used fecal transplantation (FMT) transfer prednisone-treated mice into blank reveal regulated by had similar therapeutic efficiency...
Iron-chalcogenide-based materials are promising electrode candidates in electrochemical energy storage devices because of their high specific capacities, abundant resources, low cost and environmental friendliness.
Ischemic injury to neurons represents the underlying cause of stroke brain. Our previous studies identified MG53 as an essential component cell membrane repair machinery. Here we show that recombinant human (rh)MG53 protein facilitates ischemia-reperfusion (IR) rapidly moves acute sites on neuronal cells form a patch. IR-induced brain increases permeability blood-brain-barrier, providing access from blood circulation target injured tissues. Exogenous rhMG53 can protect cultured against...
As the first limiting amino acid, lysine (Lys) has been thought to promote muscle fiber hypertrophy by increasing protein synthesis. However, functions of Lys seem far more complex than that. Despite fact that satellite cells (SCs) play an important role in skeletal growth, communication between and SCs remains unclear. In this study, we investigated whether participate directly Lys-induced growth mammalian target rapamycin 1 (mTORC1) pathway was activated both vivo vitro mediate SC response...