A5100345907- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Autophagy in Disease and Therapy
- Medical Imaging and Pathology Studies
- Epigenetics and DNA Methylation
- Stroke Rehabilitation and Recovery
- Asthma and respiratory diseases
- Virtual Reality Applications and Impacts
- Advanced Fiber Optic Sensors
- Pleural and Pulmonary Diseases
- IL-33, ST2, and ILC Pathways
- Vascular Anomalies and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Influenza Virus Research Studies
- Optical Systems and Laser Technology
- Lung Cancer Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Spectroscopy and Chemometric Analyses
- Cardiac tumors and thrombi
- Magnetic Bearings and Levitation Dynamics
- Inflammation biomarkers and pathways
- Liver Disease Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Quantum optics and atomic interactions
Tianjin haihe hospital
2018-2024
Tianjin University
1986-2024
Tianjin Infectious Diseases Hospital
2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Tianjin Medical University
2017-2024
Ministry of Education of the People's Republic of China
2023
Southwest University
2023
Columbia University Irving Medical Center
2018-2021
Xuzhou Central Hospital
2020
Abstract Efficient repair of injured epithelium by airway progenitor cells could prevent acute inflammation from progressing into chronic phase in lung. Here, we used small molecules, genetic loss-of-function, organoid cultures, and vivo lung-injury models to show that autophagy is essential for maintaining the pool stem-like vClub promoting their proliferation during ovalbumin-induced inflammation. Mechanistically, impaired disrupted glucose uptake cells, either reduced accessibility or...
Autophagy is a protective cellular mechanism in response to stress conditions. However, whether autophagy required for maintenance of the alveolar epithelium unknown. Here, we report that loss autophagy-related 5 (Atg5) AT2 cells worsened bleomycin-induced lung injury. Mechanistically, during bleomycin injury, downregulated lipid metabolism but upregulated glucose repair. Chemical blockade fatty acid synthesis promoted organoid growth and counteracted effects on genetic transporter 1,...
BackgroundHuman infections with the H7N9 virus could lead to lung damage and even multiple organ failure, which is closely associated a high mortality rate. However, metabolic basis of such systemic alterations remains unknown.MethodsThis study included hospitalized patients (n = 4) laboratory-confirmed infection, healthy controls 9), two disease control groups comprising pneumonia 9) who received steroid treatment 10). One H7N9-infected patient underwent biopsy for histopathological...
(1) Background: Abnormal repair after alveolar epithelial injury drives the progression of idiopathic pulmonary fibrosis (IPF). The maintenance integrity is based on self-renewal and differentiation type 2 (AT2) cells, which require sufficient energy. However, role glutamine metabolism in epithelium remains unclear. In this study, we investigated AT2 cells patients with IPF mice bleomycin-induced fibrosis. (2) Methods: Single-cell RNA sequencing (scRNA-seq), transcriptome, metabolomics...
Basal progenitor cells are crucial for the establishment and maintenance of tracheal epithelium. However, it remains unclear how these specified during foregut development. Here, we found that ablation Wnt chaperone protein Gpr177 (also known as Wntless) in mouse epithelium causes a significant reduction number basal accompanied by cartilage loss Shh-Cre;Gpr177loxp/loxp mutants. Consistent with association between cell development, Nkx2.1+p63+ co-present nodules Shh-Cre;Ctnnb1DM/loxp...
Bronchial asthma is an intractable pulmonary disease that affects millions of individuals worldwide, with the overproduction mucus contributing to high morbidity and mortality. Gamma‑aminobutyric acid (GABA) associated goblet cell hyperplasia in lungs primate models Club cells serve as airway epithelial progenitor may differentiate into ciliated cells. In present study, it was investigated whether GABAA receptor pi (Gabrp) essential for proliferation differentiation mice. Validation...
Hypersecretion of airway mucus caused by goblet cell metaplasia is a characteristic chronic pulmonary inflammatory diseases including asthma, cystic fibrosis (CF), and obstructive disease (COPD). Goblet cells originate from progenitor club cells. However, the molecular mechanisms features in lung are poorly understood. Herein, public single-cell RNA sequencing datasets human lungs were reanalyzed to explore transitional phase as differentiate into CF, COPD. We found that changes during...
Chronic inflammation is associated with an increased number of leukocytes in the spleen, which are then redirected to site inflammation. However, it remains unknown how leukocyte recruitment regulated. Herein, chronic was induced by intraperitoneal injection pristane into mice. Leukocytes spleen or peritoneal cavity were quantified flow cytometry. We found that loss IL-6 decreased macrophage and during pristane-induced The TNF α delayed neutrophils macrophages inhibited neutrophils,...
Lung homeostasis and regeneration depend on lung epithelial progenitor cells. Lkb1 (Liver Kinase B1) has known roles in the differentiation of airway cells during embryonic development. However, effects adult cell its mechanisms action have not been determined. In this study, we investigated mechanism by which regulates regeneration. Organoid culture showed that loss significantly reduced proliferation club alveolar type 2 (AT2) vitro. absence Lkb1, there is a slower recovery rate damaged...
Excessive nitric oxide (NO) is often observed in the airways of patients with severe asthma. Here, we show that NO donor diethylamine NONOate impairs proliferative capacity mouse club cells and induces cell apoptosis, cycle arrest, alterations lipid metabolism. Our data suggest inhibits proliferation via upregulation Gdpd2 (glycerophosphodiester phosphodiesterase domain containing 2). During ovalbumin (OVA) challenge, apoptotic are observed, but surviving continue to proliferate. OVA...
A novel artistic virtual reality (VR) environment was developed and tested for use as a rehabilitation protocol post-stroke hand therapy. The system by an interdisciplinary team of engineers, art therapists, occupational VR artists to improve patients' motivation engagement. Specific exercises were explicitly promote the practice therapeutic tasks requiring arm coordination upper extremity rehabilitation. Here we describe design, development, user testing efficiency, subject's satisfaction...
Our virtual environment represents the pre-clinical phase of an ongoing research project using a pneumatically actuated glove, head/arm tracking, and head mounted display to facilitate hand rehabilitation in stroke survivors. This is collaborative, interdisciplinary at Rehabilitation Institute Chicago involving team engineers, researchers, occupational therapists, art therapists reality artists.
A numerical method for analyzing a folded or ring cavity is presented. Astigmatic compensated parameters, stability regions, and beam parameters inside the within gain medium can be obtained numerically as long intracavity propagation expressed by round-trip matrices, no matter how complicated is. This easy to follow, results are accurate.
This study was designed to explore the safety, feasibility, and clinical efficacy of preoperative computed tomography (CT)-guided coil localization sub-fissural lung nodules (LNs). A total 105 LN patients underwent CT-guided followed by video-assisted thoracoscopic surgery (VATS)-guided wedge resection at our hospital from January 2016 December 2019. Of these patients, 4 had LNs were therefore subjected trans-fissural procedures. We analyzed data pertaining VATS procedures in patients. coils...
Objective To evaluate differences between the prism bar and synoptophore methods in measurement of fusional convergence divergence normal children. Methods This was a prospective research study. Children aged 8 to 15 years who had no ocular disease were recruited tested with their prescribed refractions. The break recovery points measured by respectively. Each test repeated 3 times. An independent samples t-test used compare difference 2 methods. Correlation two analyzed Spearman rank...
PM2.5 is known to induce lung injury, but the toxicity effect on regenerative machinery and underlying mechanisms remain unknown. In this study, primary mouse alveolar type 2 cells, considered as stem cells in gas-exchanging barrier, were sorted by fluorescence activated cell sorting for organoid cultures. By developing microfluidic technology with constricted microchannels, we observed that both passage time impedance opacities of AT2 reduced after stimulations, indicating induces a more...