A5100387768- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Mitochondrial Function and Pathology
- Infectious Diseases and Mycology
- Neuroinflammation and Neurodegeneration Mechanisms
- Studies on Chitinases and Chitosanases
- Ubiquitin and proteasome pathways
- Bone fractures and treatments
- Advanced Glycation End Products research
- Polyamine Metabolism and Applications
- Calcium signaling and nucleotide metabolism
- Cervical Cancer and HPV Research
- Toxoplasma gondii Research Studies
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Sphingolipid Metabolism and Signaling
- Lysosomal Storage Disorders Research
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Liver physiology and pathology
- Extracellular vesicles in disease
Harbin Medical University
2018-2025
Wannan Medical College
2025
First Affiliated Hospital of Harbin Medical University
2025
Beijing Anzhen Hospital
2024
Capital Medical University
2024
First Hospital of China Medical University
2022-2024
China Medical University
2022-2024
Macau University of Science and Technology
2024
Shaanxi University of Chinese Medicine
2024
Zhejiang University
2014-2023
A multilayer phase-shifting-surface-based flat plate is designed to offer a combination of lens and spiral phase (SPP) for orbital angular momentum (OAM) beam generation convergence at 60 GHz. The proposed design consists series phase-shift unit cells control the emergent form purpose focusing. results simulation experiment verify that OAM with small divergence angle can be achieved.
Mitophagy, the elimination of damaged mitochondria through autophagy, promotes neuronal survival in cerebral ischemia. Previous studies found deficient mitophagy ischemic neurons, but mechanisms are still largely unknown. We determined that BNIP3L/NIX, a receptor, was degraded by proteasomes, which led to deficiency both neurons and brains. BNIP3L exists as monomer homodimer mammalian cells, effects on unclear. Site-specific mutations transmembrane domain (S195A G203A) only formed failed...
Cervical cancer is one of the most common gynecological malignancies with poor prognosis due to constant chemoresistance and repeated relapse. Ciclopirox olamine (CPX), a synthetic antifungal agent, has recently been identified be promising anti-cancer candidate. However, detailed mechanisms related its effects remain unclear need further elucidated. In this study, we found that CPX could induce proliferation inhibition in cervical cells by targeting PARK7. Further results demonstrated...
Abstract Autophagy, a bidirectional degradative process extensively occurring in eukaryotes, has been revealed as potential therapeutic target for several cardiovascular diseases. However, its role atrial fibrillation (AF) remains largely unknown. This study aimed to determine the of autophagy electrical remodeling under AF condition. Here, we reported that autophagic flux was markedly activated atria persistent patients and rabbit model rapid pacing (RAP). We also observed key...
Abstract Efficient repair of injured epithelium by airway progenitor cells could prevent acute inflammation from progressing into chronic phase in lung. Here, we used small molecules, genetic loss-of-function, organoid cultures, and vivo lung-injury models to show that autophagy is essential for maintaining the pool stem-like vClub promoting their proliferation during ovalbumin-induced inflammation. Mechanistically, impaired disrupted glucose uptake cells, either reduced accessibility or...
Autophagy is a protective cellular mechanism in response to stress conditions. However, whether autophagy required for maintenance of the alveolar epithelium unknown. Here, we report that loss autophagy-related 5 (Atg5) AT2 cells worsened bleomycin-induced lung injury. Mechanistically, during bleomycin injury, downregulated lipid metabolism but upregulated glucose repair. Chemical blockade fatty acid synthesis promoted organoid growth and counteracted effects on genetic transporter 1,...
TP53-induced glycolysis and apoptosis regulator (TIGAR) alleviates oxidative stress protects against ischemic neuronal injury by shifting glucose metabolism into the pentose phosphate pathway (PPP). However, brain alters from PPP to during prolonged ischemia. It is still unknown whether how TIGAR exerts antioxidant activity neuroprotection in brains. Here, we determined significant upregulation of that was proportional duration failed upregulate NADPH level but alleviated cells with oxygen...
Atrial fibrillation (AF) is the most common cardiac arrhythmia, with energy metabolic disorder leading to severe clinical courses. Relaxin-2 (RLX), a peptide hormone, has been identified activate crucial enzymes involved in cellular metabolism. However, whether relaxin-2 can improve metabolism of atrial myocytes inhibit AF pathogenesis remains unknown. Male New Zealand rabbits were randomly separated into sham, right tachypacing (RAP), and RAP human recombinant treatment (0.5 mg/kg) group...
A key mediator of macroautophagy/autophagy induction is the class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1) consisting PIK3C3/VPS34, PIK3R4/VPS15, BECN1, and ATG14. Although several proteins are known to enhance or decrease PtdIns3K-C1 activity, our understanding molecular regulation still incomplete. Previously, we identified a Golgi-associated protein, GLIPR2, in screen for that interact with amino acids 267-284 region BECN1 sufficient induce autophagy when fused cell...
Hepatic fibrosis is an inflammatory response that leads to liver cirrhosis in the most advanced condition. Liver a leading cause of deaths associated with diseases; hence, understanding underlying mechanisms hepatic critical develop effective therapies. Tripartite motif (TRIM) family proteins have been shown be involved fibrosis; however, exact role several TRIM this process remained unexplored. In study, we investigated TRIM37 hepatitis B virus (HBV)-associated fibrosis. We analyzed...
Previous studies indicated cancer survivors had a higher risk of developing subsequent pancreatic ductal adenocarcinoma. However, the influence prior on survival outcomes current remains unclear.
Background: Talaromyces marneffei, also named Penicillium is an opportunistic pathogen that can cause systemic or limited infection in human beings. This especially common immunodeficiency virus (HIV)-infected hosts; however, it has been recently reported HIV-negative hosts. Here, we report a very rarely seen case of T. marneffei pulmonary non-HIV-infected patient with signal transducer and activator transcription 3 ( STAT3) mutation. Case presentation: A 34-year-old woman was admitted to...
Reticulophagy regulator 1 (RETEG1, also known as FAM134B) plays a crucial role in endoplasmic reticulum autophagy. We aimed to explore the effect of FAM134B-mediated autophagy sepsis myocardial injury mice. Sepsis mice were established via cecal ligation and puncture procedures. The expression FAM134B LC3-II/I was determined using immunohistochemistry. Myocardial tissue morphological changes apoptosis examined hematoxylin eosin (H&E) staining TUNEL analysis. effects knockdown or...
Objective Objective: Although serum C-peptide has increasingly received attention as a new and important risk factor for cardiovascular disease (CVD), the potential mechanisms remain unclear. This study aimed to investigate association between CVD high-density lipoprotein cholesterol (HDL-C) levels. Methods The present included 13,185 participants aged ≥20 years. Serum HDL-C levels were measured according standard protocol. Stratified analysis of covariance was used compare different...