A5025964613- Chemical Synthesis and Reactions
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Oxidative Organic Chemistry Reactions
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Fluorine in Organic Chemistry
- Synthesis and Characterization of Pyrroles
- Radical Photochemical Reactions
- Catalytic Cross-Coupling Reactions
- Synthesis and biological activity
- Organic and Inorganic Chemical Reactions
- Porphyrin and Phthalocyanine Chemistry
- Catalysis for Biomass Conversion
- Multicomponent Synthesis of Heterocycles
- Click Chemistry and Applications
- Organic Chemistry Cycloaddition Reactions
- Carbon dioxide utilization in catalysis
- Synthesis of heterocyclic compounds
- Immune Response and Inflammation
- Pharmacological Effects of Natural Compounds
Zhejiang University of Technology
2016-2025
Zhejiang University
2020-2025
Institute of Pharmacology
2025
Hangzhou Xixi hospital
2019-2020
China Pharmaceutical University
2019
Hangzhou Academy of Agricultural Sciences
2018
Hengdian Group DMEGC Magnetics (China)
2010-2011
Wenzhou University
2006
Lanzhou University
2002
The aim of this research is to utilize a hybrid system liposomal doxorubicin (DOX-Lip) loaded thermogel (DOX-Lip-Gel) realize the steady sustained delivery (DOX), small hydrophilic drug, for treatment breast cancer locally. Herein, was prepared via traditional film dispersion method with particle size 75 nm and drug entrapment efficiency 86%. And, triblock copolymer poly (D, L-lactide-co-glycolide)-b-poly (ethylene glycol)-b-poly L-lactide -co-glycolide) (PLGA-PEG-PLGA) synthesized...
TP53-induced glycolysis and apoptosis regulator (TIGAR) alleviates oxidative stress protects against ischemic neuronal injury by shifting glucose metabolism into the pentose phosphate pathway (PPP). However, brain alters from PPP to during prolonged ischemia. It is still unknown whether how TIGAR exerts antioxidant activity neuroprotection in brains. Here, we determined significant upregulation of that was proportional duration failed upregulate NADPH level but alleviated cells with oxygen...
An efficient and highly regioselective C6-phosphorylation protocol for pyrrolo[2,3-d]pyrimidine (7-DAP) derivatives with various H-phosphine oxides induced by visible light at room temperature is described the first time. This has been successfully achieved combination of Na2-eosin Y as a photocatalyst LPO an oxidant under transition metal- additive-free conditions. The broad substrate scope, good functional group tolerance, excellent regioselectivity, air tolerant conditions make this...
Abstract A catalyst-free, three-component dearomatization of phenols with aryldiazonium tetrafluoroborates and DABCO·(SO2)2 has been developed for the synthesis 4-(arylsulfonyl)cyclohex-2,5-dien-1-one scaffolds. This method offers mild reaction conditions high step efficiency, providing a green efficient strategy phenols. Mechanistic studies indicated that this transformation relies on tandem radical sulfur dioxide insertion process.
Bortezomib (BTZ) serves as a first-line medication for multiple myeloma (MM) therapy. Unfortunately, despite its prominent efficacy in MM therapy, BTZ-induced peripheral neuropathy (BIPN) presents significant challenge patients lacks an established therapeutic solution. Previous research has demonstrated the involvement of lysosomal dysfunction Schwann cells key pathological process BIPN, suggesting that agents enhancing activity could hold promise treatment BIPN. Gallic acid (GA) is natural...
Cap-and-trade mechanism can efficiently reduce carbon emissions, which makes it widely used around the world. This paper builds a Stackelberg game model for manufacturer-led secondary supply chain and analyzes best pricing, reduction strategies, impacts of each variable on equilibrium results when using two emission methods, recycling & remanufacturing, technology upgrading under cap-and-trade mechanism. The relationship between variables was verified through case studies, economic...
Clean thiolysis reaction of various epoxides in ionic liquids (ILs) without the use any catalyst generates β-hydroxy sulfides excellent yields (83–98%) with high regioselectivity and chemoselectivity under mild conditions.
Here we report a site-selective synthesis of functionalized dibenzo[f,h]quinolines and their derivatives, which could be used as OLED materials. The key step is the double cross coupling reaction between 2-chloropyridinyl acids cyclic diaryliodonium salts, where carboxylic acid was unprecedentedly employed both traceless directing group functional handle in one-pot atom- step-economical process.
A mild and selective C6 arylation strategy for pyrrolo[2,3-d]pyrimidine derivatives with arylboronic acids at room temperature is described. This unified protocol has been achieved by the synergistic combination of Pd(II)/TEMPO catalysis CF3CO2H promotion under silver-, base-, additive-free conditions. The broad substrate scope, good functional group tolerance, excellent regioselectivity, air moisture tolerant conditions make this process attractive effective synthesis modification targeted...
A series of amidated and phosphoramidated pyrrolo[2,3- d ]pyrimidine derivatives were synthesized by Ru-catalysed direct C–H amidation using azides as amino sources in a mild, efficient highly site-selective manner.
A palladium-catalysed direct arene C-H fluoroalkoxylation of 4-aryl-pyrrolo[2,3-d]pyrimidine derivatives with fluorinated alcohols is described. Highly site-selective mono- or bis-fluoroalkoxylation can be achieved by tuning the reaction conditions, affording various fluoroalkoxylated pyrrolo[2,3-d]pyrimidine in moderate to good yields, which offer rational tailoring their biological activity for application field pharmaceutical chemistry.
The protocol features operational simplicity, mild reaction conditions, and the use of FeCl 3 as catalyst thiols/disulfides sulfur sources, which enables transformation diverse benzylic C–H bonds into C–S with a high efficiency.
Mukaiyama-type aldol coupling of typical silyl enolates 2-4 with aryl or vinyl aldehydes and acetals was realized in the presence 1-5 mol % MgI(2) etherate (1) a mild, efficient, highly chemoselective manner. Iodide counterion, weakly coordinating peripheral ethereal ligands (Et(2)O) Mg(II), noncoordinating reaction media (i.e. CH(2)Cl(2)) are among critical factors for unique reactivity this catalytic system. [reaction: see text]
Pd-Catalyzed one-pot direct <italic>ortho</italic> C–H arylation of pyrrolo[2,3-<italic>d</italic>]pyrimidine derivatives is reported. This protocol provides a variety biphenyl-containing pyrrolo[2,3-<italic>d</italic>]pyrimidines in good to excellent yields.
Transition-metal-free catalyzed direct C(sp<sup>2</sup>)–H acetoxylation of pyrrolo[2,3-<italic>d</italic>]pyrimidine derivatives is reported. This protocol provides a variety acetoxylated pyrrolo[2,3-<italic>d</italic>]pyrimidines in good to excellent yields.
We described a mild and efficient procedure for the synthesis of 3-aryloxazolidin-2-ones via cycloaddition isocyanates with epoxides in presence MgI2 etherate (MgI2 • (OEt2)n) good yields.