A5064038244- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Organic Light-Emitting Diodes Research
- Luminescence and Fluorescent Materials
- Organic Electronics and Photovoltaics
- Nanoplatforms for cancer theranostics
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Crystallography and molecular interactions
- Cellular transport and secretion
- Advanced Polymer Synthesis and Characterization
- Monoclonal and Polyclonal Antibodies Research
- Fungal and yeast genetics research
- Dendrimers and Hyperbranched Polymers
- Porphyrin and Phthalocyanine Chemistry
- Lanthanide and Transition Metal Complexes
- Glycosylation and Glycoproteins Research
- Conducting polymers and applications
- Photochromic and Fluorescence Chemistry
- Microtubule and mitosis dynamics
- Molecular Sensors and Ion Detection
- Cytokine Signaling Pathways and Interactions
- Radical Photochemical Reactions
- Advanced Biosensing Techniques and Applications
- Sensorless Control of Electric Motors
Emory University
2025
Wenzhou Medical University
2019-2024
Jinan Central Hospital
2023-2024
Shandong University
2005-2024
Wuhan University of Technology
2024
Soochow University
2021-2024
Chaozhou Central Hospital
2024
First Hospital of Jilin University
2024
Jilin University
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2019-2024
White polymer light-emitting devices with a peak forward-viewing power efficiency close to 40 lm W−1, corresponding an external quantum of 28.8% and luminous 60 cd A−1, are demonstrated. The based on two newly synthesized yellow-emitting iridium complexes functionalized the sterically hindered diarylfluorene chromophores fabricated by simple solution-processing method.
Two-photon fluorescence microscopy (TPFM) provides key advantages over conventional imaging techniques, namely, increased penetration depth, lower tissue autofluorescence and self-absorption, reduced photodamage photobleaching therefore is particularly useful for deep tissues animals. Enzyme-detecting, small molecule probes provide powerful alternatives fluorescent protein (FP)-based methods in bioimaging, primarily due to their favorable photophysical properties, cell permeability, chemical...
Fluorescence imaging provides an indispensable way to locate and monitor biological targets within complex dynamic intracellular environments. Of the various agents currently available, small molecule-based probes provide a powerful tool for live cell imaging, primarily due their desirable properties, including permeability (as result of smaller sizes), chemical tractability (e.g., different molecular structures/designs can be installed), amenability wide variety events. With few exceptions,...
The therapeutic applications of exogenous nitric oxide are usually limited by its short half-life and vulnerability to many biological substances, thus straightforward precise spatiotemporal control NO delivery may be critical effects. Herein, the mitochondria-targeted photoresponsive NO-releasing nanosystem is demonstrated as a new approach for cancer treatment. fabricated covalently incorporating photo-donor mitochondria targeting ligand onto carbon-dots; accordingly, multi-functionalities...
The synthesis, isomerism, photophysics and electrophosphorescent characterization of some functional cyclometallated iridium(III) complexes containing 2-[2-(N-phenylcarbazolyl)]pyridine 2-[3-(N-phenylcarbazolyl)]pyridine molecular frameworks are described. A carbazole-based coplanar molecule (CmInF) obtained through the intramolecular ring closure aryl substitutions at C3 C6 positions exhibits a high triplet energy (ET = 2.77 eV), morphological stability (Tg 195 °C) hole mobility in range up...
Photosensitizer doped conjugated polymer nanoparticles have been prepared by incorporating polyoxyethylene nonylphenylether (CO-520) into the using a re-precipitation method. The polymer, poly[9,9-dibromohexylfluorene-2,7-ylenethylene-alt-1,4-(2,5-dimethoxy)phenylene] (PFEMO), was used as host matrix to disperse tetraphenylporphyrin (TPP) and an energy donor enhance two-photon excitation properties of TPP. These CO-520 incorporated, TPP-doped PFEMO are stable low cytotoxicity in dark. TPP...
The aim of this research is to utilize a hybrid system liposomal doxorubicin (DOX-Lip) loaded thermogel (DOX-Lip-Gel) realize the steady sustained delivery (DOX), small hydrophilic drug, for treatment breast cancer locally. Herein, was prepared via traditional film dispersion method with particle size 75 nm and drug entrapment efficiency 86%. And, triblock copolymer poly (D, L-lactide-co-glycolide)-b-poly (ethylene glycol)-b-poly L-lactide -co-glycolide) (PLGA-PEG-PLGA) synthesized...
Here we report a novel quadruple-stimuli-responsive block copolymer nanocarrier sensitive to pH, temperature, light, and reducing agent. The well-defined amphiphilic diblock poly(2-nitrobenzyl methacrylate)-SS-poly(dimethylaminoethyl methacrylate) (PNBM-SS-PDMAEMA) was synthesized via two steps of atom transfer radical polymerization (ATRP). In aqueous solution, the self-assembled into nanoparticles consisting light-responsive hydrophobic PNBM core, pH- temperature-responsive hydrophilic...
Photodynamic therapy (PDT) has been recognized as a valuable treatment option for localized cancers. Herein, we demonstrate cellular and subcellular targeted strategy to facilitate PDT efficacy. The system was fabricated by incorporating cationic porphyrin derivative (MitoTPP) onto the polyethylene glycol (PEG)-functionalized folic acid-modified nanographene oxide (NGO). For this system, NGO serves carrier MitoTPP well quencher MitoTPP's fluorescence singlet oxygen ((1)O2) generation....
Multiple resonance (MR) type thermally activated delayed fluorescence (TADF) emitters have attracted much recent attention due to their narrow emission spectra and high photoluminescence quantum yields (PLQYs). Spectral broadening concentration quenching at doping concentrations are two issues currently limiting the development of MR-TADF emitters. However, origins these not been fully clarified so far. In this work, by investigating with same MR cores but peripheral groups different steric...
Hindered by spectral broadening issues with redshifted emission, long-wavelength (e.g., maxima beyond 570 nm) multiple resonance (MR) emitters full width at half (FWHMs) below 20 nm remain absent. Herein, strategically embedding diverse boron (B)/nitrogen (N) atomic pairs into a polycyclic aromatic hydrocarbon (PAH) skeleton, we propose hybrid pattern for the construction of narrowband MR emitter. The proof-of-concept emitter B4N6-Me realized orange-red emission an extremely small FWHM 19...
Building blocks and heteroatom alignments are two determining factors in designing multiple resonance (MR)-type thermally activated delayed fluorescence (TADF) emitters. Carbazole-fused MR emitters, represented by CzBN derivatives, the of ν-DABNA star series MR-TADF emitters that show impressive performances from aspects building alignments, respectively. Herein, a novel analog, Π-CzBN, featuring alignment is developed via facile one-shot lithium-free borylation. Π-CzBN exhibits superior...
Abstract Multiple resonance (MR) type thermally activated delayed fluorescence (TADF) emitters are very promising in the high‐resolution and high‐efficiency displays, due to their narrow highly efficient optical emissions. Early MR‐TADF cores that show only short‐range charge‐transfer (CT) electronic excitations hardly afford ideal performances (e.g., low efficiencies) organic light‐emitting diodes (OLEDs). This work thus designs synthesizes two (TCzBN‐BP TCzBN‐FP), where same MR core TCzBN...
Abstract For multiple resonance (MR) type thermally activated delayed fluorescence (TADF) emitters, electron cloud distributions of their π‐conjugated planes are crucial for determining eventual performance. Currently, modulation attempts MR‐TADF emitters mainly inside the planes. Possible out‐of‐plane interactions may also significantly impact photophysical properties, but exploration is quite limited. Here, a novel concept using (e.g., π–π and lone pair‐π) to introduce spatial perturbation...
The Rho3 and Cdc42 members of the Rho GTPase family are important regulators exocytosis in yeast. However, precise mechanism by which they regulate this process is controversial. Here, we present evidence that Exo70 component exocyst complex a direct effector both Cdc42. We identify gain-of-function mutants EXO70 potently suppress RHO3 CDC42 defective for exocytic function. show has biochemical properties expected Surprisingly, find C-terminal prenylation these GTPases promotes interaction...
Novel multifunctional nanoparticles that combine two functionalities (a gold nanorod core and a porphyrin-doped mesoporous silica shell) into one entity were synthesized. Due to the encapsulation of silica, porphyrin can be well protected against external bioenvironment. In addition, generated singlet oxygen by molecules easily released from silica. We have demonstrated these generate with relatively higher yield compared free porphyrin. These nanocomposites are attractive candidates for...
The way to a 14-3-3 binder: A fragment-based combinatorial small-molecule microarray generates affinity-based fingerprints of the 14-3-3σ protein. One small molecule (see picture; in red box) that disrupts 14-3-3/protein interaction (green/blue) has been identified. compound is cell-permeable and possesses both vitro in-cell activities. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They...
A ratiometric two-photon probe with a large Stokes shift has been developed to practically achieve sensing β-galactosidase in cells and mice.
Rho GTPases are important regulators of polarity in eukaryotic cells. In yeast they involved regulating the docking and fusion secretory vesicles with cell surface. Our analysis a Rho3 mutant that is unable to interact Exo70 subunit exocyst reveals normal polarization complex as well other markers. We also find there no redundancy between Rho3–Exo70 Rho1–Sec3 pathways localization exocyst. This suggests Cdc42 act polarize exocytosis by activating exocytic machinery at membrane without need...