A5100365432- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Machine Learning in Bioinformatics
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Protein Structure and Dynamics
- Nutritional Studies and Diet
- Cancer Immunotherapy and Biomarkers
- RNA and protein synthesis mechanisms
- Chromosomal and Genetic Variations
- Bladder and Urothelial Cancer Treatments
- Inflammatory Bowel Disease
- Lipid metabolism and disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- Plant-based Medicinal Research
- Metabolism and Genetic Disorders
- IL-33, ST2, and ILC Pathways
Chongqing University
2023-2025
Zhejiang University
2014-2024
Zhejiang Lab
2023-2024
Qingdao Eighth People's Hospital
2024
Chinese PLA General Hospital
2014-2024
Anhui Medical University
2024
Fudan University
2024
Central South University
2021-2024
Ningxia University
2024
Children's Hospital of Zhejiang University
2020-2024
Activated T cells release bioactive Fas ligand (FasL) in exosomes, which subsequently induce self-apoptosis of cells. However, their potential effects on cell apoptosis tumors are still unknown. In this study, we purified exosomes expressing FasL from activated CD8(+) OT-I mice and found that had little effect proliferation tumor but promoted the invasion B16 3LL cancer vitro via Fas/FasL pathway. increased amount cellular FLICE inhibitory proteins ERK NF-κB pathways, MMP9 expression murine...
Organismal aging is driven by interconnected molecular changes encompassing internal and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets (gathering information from genomics, epigenomics, transcriptomics, proteomics, metabolomics pharmacogenomics), at either populational or single-cell levels, can provide a multi-dimensional, integrated profile the heterogeneous process with unprecedented throughput detail. These new strategies allow for exploration...
Abstract How the intestinal tract develops a tolerance to foreign antigens is still largely unknown. Here we report that extracellular vesicles (EVs) with TGF-β1-dependent immunosuppressive activity are produced by epithelial cells (IECs) under physiological conditions. Transfer of these EVs into inflammatory bowel disease (IBD) mice induced dextran sulfate sodium salt decreases IBD severity inducing regulatory T and dendritic cells. In contrast, decreased endogenous EV production promotes...
Abstract Foxp3 + regulatory T cells (Tregs) can inhibit immune responses and maintain tolerance by secreting immunosuppressive TGF-β1 IL-10. However, the efficiency of Tregs become major obstacle to their use for immunotherapy. In this study, we investigated relevance C-type lectin receptor CD69 suppressive function. Compared CD4 − (CD69 Tregs), Tregs) displayed stronger ability tolerance. expressed higher levels suppression-associated markers such as CTLA-4, ICOS, CD38 GITR, secreted IL-10...
Systemic inflammation caused by dysfunctional macrophages is a crucial pathogenetic event in preeclampsia (PE). Trophoblast-derived extracellular vesicles (T-EVs) are potent immune cell signaling modulators pregnancy. Herein, we aimed to investigate T-EVs' effect and mechanism on macrophage polarization its role PE pathogenesis, which remain unclear.Flow cytometry immunochemistry were used determine placental phenotypes. T-EVs immuno-isolated via alkaline phosphatase antibody identified...
The inflammasome-related protein NLRP1/NALP1 has been implicated in the onset and progression of some autoimmune diseases. This study was undertaken to determine whether a polymorphism NLRP1 gene is associated with susceptibility rheumatoid arthritis (RA) Han Chinese assess functional implications this association.RA patients (n = 190) matched healthy controls residing city Chengdu were genotyped for promoter polymorphisms rs6502867 rs878329. Genotyping rs878329 performed second set subjects...
We have previously demonstrated that exosomes from dendritic cells (DCs) secreting TGF‐β1 (sTGF‐β1‐EXOs) delay the development of murine inflammatory bowel disease (IBD). In this study, we isolated DCs expressing membrane‐associated (mTGF‐β1‐EXOs) and found mTGF‐β1‐EXOs had more potent immunosuppressive activity than sTGF‐β1‐EXOs in vitro. Treatment mice with inhibited progression myelin oligodendrocyte glycoprotein (MOG) peptide‐induced EAE even after onset. also impaired Ag‐specific Th1...
OBJECTIVES: Biologic therapies have been available for inflammatory bowel disease >20 years, but patient outcomes not changed appreciably over this time period. To better understand medication utilization disease, we evaluated a novel technique visualizing treatment pathways, including initial treatment, switching, and combination therapies. METHODS: This retrospective, observational study used administrative claims data from the Truven Health MarketScan Commercial Medicare Database....
Background Locoregional therapy combined with systemic can further improve the prognoses for HCC. However, efficacy of TACE ICIs and TKIs HCC whether this triple activate immune response are still unknown. Purpose To identify TACE+ICIs+TKIs unresectable hepatocellular carcinoma (uHCC) its effect on immunity. Materials Methods This single-center retrospective study was approved by Institutional Review Board. From August 1, 2019, to March 30, 2021, patients uHCC who received combination were...
Abstract Ulcerative colitis (UC) is a common inflammatory bowel disease driven by the dyshomeostasis of intestinal immune system and microbiota, but its treatment options are limited due to impaired epithelial barrier integrity function. Herein, multifunctional biomimetic hydrogel developed as artificial colonic mucosa, which can readily establish bioadhesive at ulcer site restore local microbial homeostasis exert potent anti‐inflammatory effect. The framework generated through...
Dynamic tracing of intracellular telomerase activity plays a crucial role in cancer cell recognition and correspondingly earlier diagnosis personalized precision therapy. However, due to the complexity required reaction system insufficient loading components into cells, achieving high-fidelity determination is still challenge. Herein, an Aptamer-Liposome mediated Telomerase activated poly-Molecular beacon Arborescent Nanoassembly(ALTMAN) approach was described for direct visualization...
Traumatic brain injury (TBI), also known as head or injury, refers to the caused by mechanical impact. It is necessary develop effective new therapies for TBI injury. Gastrodin (GAS) main bioactive ingredient from rhizome of Gastrodia elata and has significant therapeutic effect on nervous system diseases. However, protective effects GAS tissue related regulatory mechanism in traumatic remain elusive. Herein, we explored role its mechanism. We found reduced improved functional recovery nerve...
Stem cell transplantation has been proved a promising therapeutic instrument in intervertebral disc degeneration (IVDD). However, the elevation of oxidative stress degenerated region impairs efficiency mesenchymal stem cells (BMSCs) treatment via exaggeration mitochondrial ROS and promotion BMSCs apoptosis. Herein, we applied an emulsion-confined assembly method to encapsulate Coenzyme Q10 (Co-Q10), hydrophobic antioxidant which targets mitochondria ROS, into lecithin micelles, renders...
Abstract Background Combined oxidative phosphorylation deficiency (COXPD) is a severe disorder with early onset and autosomal recessive inheritance, has been divided into 51 types (COXPD1–COXPD51). COXPD14 caused by mutation in the FARS2 gene, which encodes mitochondrial phenylalanyl-tRNA synthetase (mt-PheRS), an enzyme that transfers phenylalanine to its cognate tRNA mitochondria. Since first case was reported 2012, increasing number of variations have subsequently identified, present...
Abstract The DEPTOR-mTORC1/2 axis has been shown to play an important, but a context dependent role in the regulation of proliferation and survival various cancer cells cell culture settings. vivo DEPTOR tumorigenesis remains elusive. Here we showed that levels both protein mRNA were substantially decreased human prostate tissues, which positively correlated with disease progression. depletion accelerated survival, migration, invasion cells. Mechanistically, not only activated mTORC1 mTORC2...
Background: Sanguisorba Officinalis L. (SO) is a well-known traditional Chinese medicine (TCM), commonly applied to treat complex diseases, such as anticancer, antibacterial, antiviral, anti-inflammatory, anti-oxidant and hemostatic effects. Especially, it has been reported exert anti-tumor effect in various human cancers. However, its pharmacological mechanism on hepatocellular carcinoma (HCC) remains unclear. Methods: In this study, network pharmacology approach was characterize the...
Alzheimer's disease (AD) is a typical neurodegenerative disease, which occurs in the elderly population.