A5101604300- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Mast cells and histamine
- CAR-T cell therapy research
- PI3K/AKT/mTOR signaling in cancer
- Histone Deacetylase Inhibitors Research
- Ion channel regulation and function
- Protein Degradation and Inhibitors
- Cellular transport and secretion
- Seaweed-derived Bioactive Compounds
- Respiratory and Cough-Related Research
- TGF-β signaling in diseases
- Enzyme function and inhibition
- Wnt/β-catenin signaling in development and cancer
- Venomous Animal Envenomation and Studies
- Barrier Structure and Function Studies
- Pediatric health and respiratory diseases
- Biochemical and Structural Characterization
- Plant-derived Lignans Synthesis and Bioactivity
- Plant-based Medicinal Research
- Biochemical Acid Research Studies
Soochow University
2014-2023
First Affiliated Hospital of Soochow University
2018-2023
Shanghai Institute of Pharmaceutical Industry
2020
Shanghai University of Engineering Science
2020
Beijing Radiation Center
2016-2018
The First Hospital of Kunming
2017
Kunming General Hospital of Chengdu Military Command
2007-2015
Second Affiliated Hospital of Kunming Medical College
2000-2007
Kunming Medical University
2000-2007
TGFβR1 plays an important role in TGF-β signaling transduction and serves as a tumor suppressor. Our previous studies show that reduced expression of is common non-small cell lung cancer (NSCLC) variants confer risk NSCLC. However, the epigenetic mechanisms underlying NSCLC carcinogenesis are still elusive. We investigated function regulation signaling-based miRNAs Computational algorithms predicted 3′-untranslated region (3′-UTR) target miR-142-3p. Here luciferase reporter assay confirmed...
The toxic side effects of doxorubicin (DOX) have limited its use in chemotherapy. Neither liposomal DOX nor pegylated are able to completely resolve this issue. This is a proof-of-concept study testing aptamer-drug conjugate (ApDC) targeted delivery systems for chemotherapeutic drugs.Aptamer library targeting human epidermal growth factor receptor 3 (HER3) was screened and affinity determined by enzyme-linked immunosorbent assay. Specificity tested MCF-7HER3-high, BT474HER3-high,...
Abstract Background Epithelial-mesenchymal transition (EMT) has been associated with wound healing, tumorigenesis, and metastasis. Circular RNAs (circRNAs) are functional non-coding involved in multiple human cancers. However, whether how circRNAs contribute to the EMT hepatocellular carcinomas (HCC) remains be deciphered. In this study, we investigated regulation function of hsa_circ_0003288 on programmed death-1 ligand 1 (PD-L1) during HCC invasiveness. Methods Hsa_circ_0003288 expression...
Background Locoregional therapy combined with systemic can further improve the prognoses for HCC. However, efficacy of TACE ICIs and TKIs HCC whether this triple activate immune response are still unknown. Purpose To identify TACE+ICIs+TKIs unresectable hepatocellular carcinoma (uHCC) its effect on immunity. Materials Methods This single-center retrospective study was approved by Institutional Review Board. From August 1, 2019, to March 30, 2021, patients uHCC who received combination were...
The epithelial-to-mesenchymal transition (EMT) status is associated with programmed death-1 ligand 1 (PD-L1) expression in various cancers. However, the role and molecular mechanism of PD-L1 EMT sorafenib-resistant hepatocellular carcinoma (HCC) cells remain elusive. In this study, we aimed to investigate regulation on HCC cells. Initially, cell lines HepG2 SR Huh7 were established. Western-blot assays used detect PD-L1, E-cadherin, N-cadherin. intervention overexpression explore Cell...
Tumour immunosuppressive microenvironments inhibit antigen-specific cellular responses and interfere with CpG-mediated immunotherapy. Overcoming tumour microenvironment (TME) immunosuppression is an important strategy for effective therapy. This study investigated the ability of a tumour-targeting IL-4Rα aptamer-liposome-CpG ODN delivery system to introduce CpG into tumours overcome TME. The IL-4Rα-liposome-CpG was prepared. FAM-CpG visualisation used demonstrate targeting in vitro vivo....
In the current study, nano-hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) ceramics scaffolds loaded with cationic liposomal ceftazidime (CLCs) prepared by modified reverse phase evaporation method, investigations of their release characteristics were performed dissolution tests, in vitro anti-biofilm activity was studied determination bacterial susceptibility ELISA. The mean particle size, zeta potential, pH and entrapment efficiency CLCs 161.5 ± 5.37 nm, 60.60 5.24 mV, 6.90 0.07 16.57...
Staphylococcus aureus is one of the most frequently occurring hospital- and community-associated pathogenic bacteria featuring high morbidity mortality. The occurrence methicillin-resistant S. (MRSA) has increased persistently over years. Therefore, developing novel anti-MRSA drugs to circumvent drug resistance highly important. Roemerine, an aporphine alkaloid, previously been reported exhibit antibacterial activity. present study aimed investigate whether roemerine can maintain these...
Pancreatic cancer (PaC) is an aggressive malignancy, which associated with high levels of metastasis. Circulating tumor cells (CTCs), may be considered a functional biomarker and promising treatment strategy for metastasis, are the prognosis progression various metastatic cancers, including PaC. Receptor tyrosine kinase‑like orphan receptor 1 (ROR1) expression contributes to cell metastasis poor clinical outcomes in malignant tumors. The present study aimed explore function ROR1 PaC CTCs....
The claudin 18.2(CLDN18.2) antigen is highly expressed in gastric mucosa epithelial cells and frequently malignant tumors. Positive clinical outcomes have popularized 18.2 as a novel cellular antibody therapeutic. Here, we designed bispecific antibody-ZWB67 using the XFab® platform, aimed at redirecting CD3+ effector T to CLDN18.2+ target or tissues. Physicochemical characterization, binding properties, cell stimulatory activity, cell-dependent cytotoxicity of ZWB67 were evaluated dosage...
Circular RNAs (circRNAs) may be involved in tumorigenesis. Recently, the role of circRNAs hepatocellular carcinoma (HCC) has drawn wide attention. Herein, we aimed to explore regulation and function hsa_circ_0005239 malignant biological behavior angiogenesis HCC, as well link between programmed cell death ligand 1 (PD-L1) HCC. Quantitative real-time polymerase chain reaction (qRT-PCR) assays revealed that was upregulated HCC tumor samples lines. Furthermore, a series vitro vivo explored...
In this study, a new LC-ESI-MS/MS-based method was validated for the quantitation of hemslecin A in rhesus monkey plasma using otophylloside as internal standard (IS). Hemslecin and IS were extracted from liquid-liquid extraction sample clean-up procedure, subjected to chromatography on Phenomenex Luna CN column (150 × 2.0 mm, 3.0 µm) with mobile phase consisting methanol 0.02 mol/mL ammonium acetate (55:45, v/v) at flow rate 0.2 mL/min. Detection performed an Agilent G6410B tandem mass...
Abstract A series of c-Met/histone deacetylase (HDAC) bifunctional inhibitors was designed and synthesized by merging pharmacophores c-Met HDAC inhibitors. Among them, the most potent compound, 2o, inhibited kinase HDACs, with IC50 values 9.0 31.6 nM, respectively, showed efficient antiproliferative activities against both A549 HCT-116 cancer cell lines greater potency than an equimolar mixture respective two enzymes: crizotinib vorinostat (SAHA). Our study provided strategy for discovery...
Bio-macromolecules have potential applications in cancer treatment due to their high selectivity and efficiency hitting therapeutic targets. However, poor cell membrane permeability has limited broad-spectrum application treatment. The current study developed highly internalizable anti-c-MET antibody Fab fusion proteins with intracellular epitope peptide chimera achieve the dual intervention from extracellular targets tumor therapy. In vitro experiments demonstrated that could interfere...
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