A5102898228- Pluripotent Stem Cells Research
- Medicinal Plant Pharmacodynamics Research
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Hepatitis C virus research
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Drug-Induced Hepatotoxicity and Protection
- Natural product bioactivities and synthesis
- Cancer Cells and Metastasis
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Nephrotoxicity and Medicinal Plants
- Birth, Development, and Health
- Ginseng Biological Effects and Applications
- Per- and polyfluoroalkyl substances research
- Cancer, Hypoxia, and Metabolism
- Nitric Oxide and Endothelin Effects
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Prostate Cancer Treatment and Research
- Neurological Disease Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Parkinson's Disease Mechanisms and Treatments
- Toxin Mechanisms and Immunotoxins
Institute of Pharmacology
2008-2025
Zhejiang University
2016-2025
People's Hospital of Xinjiang Uygur Autonomous Region
2025
Wenzhou Medical University
2014-2024
The First Affiliated Hospital, Sun Yat-sen University
2018-2023
Sun Yat-sen University
2018-2023
Renji Hospital
2023
Nanjing Medical University
2013-2020
Shanghai Public Security Bureau
2020
Luoyang Central Hospital Affiliated to Zhengzhou University
2016-2018
We previously reported that treatment of icariin could significantly induce cardiomyocyte differentiation murine embryonic stem (ES) cells in vitro. In the present study, exact activity initiated by was further confirmed and underlying molecular mechanism investigated. found efficiently stimulated only if administrated between days 5 8 course, which indicated with elevated percentage embryoid bodies (EB) beating areas up- regulated expression alpha-actinin troponin T. Exposure triggered...
Abstract The significant promoting effects of some prenylflavonoids on cardiac differentiation mouse embryonic stem (ES) cells via reactive oxygen species (ROS) signaling pathway were investigated. most effective was facilitated by icariin (ICA), followed icaritin (ICT), while desmethylicaritin (DICT) displayed the weakest but still inducible effect. Contrarily, DICT demonstrated strongest anti‐oxidative activity ICA only little in vitro, which well matched with hydroxyl (OH) numbers and...
Etomidate is a rapid hypnotic intravenous anesthetic agent. The major side effect of etomidate the reduced plasma concentration corticosteroids, leading to abnormal reaction adrenals. Cortisol and testosterone biosynthesis has similar biosynthetic pathway, shares several common steroidogenic enzymes, such as P450 chain cleavage enzyme (CYP11A1) 3β-hydroxysteroid dehydrogenase 1 (HSD3B1). on Leydig cell steroidogenesis during maturation process not well established.Immature cells isolated...
It is unclear whether patients with Global Initiative for Chronic Obstructive Lung Disease stage 1 (mild) chronic obstructive pulmonary disease (COPD) have a higher risk of all-cause mortality than participants normal spirometry results. We used the data from National Health and Nutrition Examination Survey (NHANES) III 2007-2012, which included aged 20-79 years, to investigate mild COPD (whole population subgroups) spirometry. Mild was defined as prebronchodilator forced expiratory volume...
Bortezomib (BTZ) serves as a first-line medication for multiple myeloma (MM) therapy. Unfortunately, despite its prominent efficacy in MM therapy, BTZ-induced peripheral neuropathy (BIPN) presents significant challenge patients lacks an established therapeutic solution. Previous research has demonstrated the involvement of lysosomal dysfunction Schwann cells key pathological process BIPN, suggesting that agents enhancing activity could hold promise treatment BIPN. Gallic acid (GA) is natural...
Abstract Homocysteine (Hcy) is a sulfur‐containing amino acid that originated in methionine metabolism and the elevated level of Hcy plasma considered to be an independent risk factor for cardiovascular diseases (CVD). Endothelial dysfunction plays major role development CVD, while potential mechanism Hcy‐induced endothelial still unclear. Here, Hcy‐treated cells, we observed destruction mitochondrial morphology decline membrane potential. Meanwhile, ATP was reduced reactive oxygen species...
Aristolochic acid I (AAI) existing in plant drugs from Aristolochia species is an environmental human carcinogen associated with urothelial cancer. Although gene association network analysis demonstrated expression profile changes the liver of TP53 knock-in mice after acute AAI exposure, to date, whether causes hepatic tumorigenesis still not confirmed. Here, we show that premalignant alterations appeared canines a 10-day oral administration (3 mg/kg/day). We observed c-Myc oncoprotein and...
Rictor is a key component of the mammalian target rapamycin complex 2 (mTORC2) and required for Akt phosphorylation (Ser473). Our previous study shows that knockdown prevents cardiomyocyte differentiation from mouse embryonic stem (ES) cells induces abnormal electrophysiology ES cell-derived cardiomyocytes (ESC-CMs). Besides, causes down-expression connexin 43 (Cx43), predominant gap junction protein, located in both sarcolemma mitochondria cardiomyocytes. Mitochondrial Cx43 (mtCx43) plays...