A5061120541- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dialysis and Renal Disease Management
- Anesthesia and Neurotoxicity Research
- Pain Mechanisms and Treatments
- Neurological Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Intestinal and Peritoneal Adhesions
- Abdominal Surgery and Complications
- Central Venous Catheters and Hemodialysis
- Plant Micronutrient Interactions and Effects
- Nicotinic Acetylcholine Receptors Study
- Transplantation: Methods and Outcomes
- Pain Management and Opioid Use
- Peptidase Inhibition and Analysis
- Ion channel regulation and function
- Cancer, Lipids, and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Biochemical effects in animals
- Neuropeptides and Animal Physiology
- Protein Kinase Regulation and GTPase Signaling
- Histone Deacetylase Inhibitors Research
Jiaxing University
2023-2025
China Three Gorges University
2013-2025
Huazhong University of Science and Technology
2007-2025
University of Illinois Urbana-Champaign
2024
Zhejiang University
2009-2024
Bridge University
2023
Zhongnan Hospital of Wuhan University
2023
Wuhan University
2023
Michigan Medicine
2019
Luohe Medical College
2019
Abstract Purpose: Convective transport of macromolecules from the peritoneal cavity into tumor is determined by its hydraulic permeability and pressure gradient. Previous studies showed that establishing a gradient failed to result in significant penetration. This study addresses hypothesis extracellular matrix major resistance penetration an i.p. injected antibody. Experimental Design: Human ovarian tumors (SKOV-3 OVCAR-3) were established abdominal wall athymic rats. After anesthesia,...
Limited information is available on the role of brassinosteroids (BRs) in response plants to nutrient deficiency. To understand functions BRs iron deficiency, we investigated effect 24-epibrassinolide (EBR) activities ferric-chelate reductase (FCR), H+-ATPase, Ca2+-ATPase, nitrate (NR), antioxidant enzymes, Fe and other minerals content distribution, chlorophylls, soluble protein, free proline, reactive oxygen species, malondialdehyde peanut (Arachis hypogea L.) subjected deficiency (10-5 M...
Most current animal models that are used to study effects of long-term peritoneal exposure dialysis solutions use an indwelling catheter for daily injections. It was hypothesized the presence a foreign body in cavity (PC) might alter inflammatory response and would depend on duration. For addressing these, injections were carried out 2 8 wk 90 Sprague-Dawley rats: 40 via subcutaneous port connected silicone tunneled PC, direct needle injection, 10 noninjected, age-control rats. Daily volumes...
ABSTRACT To elucidate physiological mechanisms of zinc (Zn) efficiency in rice (Oryza sativa L.), comparative studies on root morphology, ultrastructure, and oxidative enzyme activities were investigated using Zn-efficient genotype ('IR8192') Zn-inefficient ('Erjiufeng'). The results showed that moderate Zn-deficient conditions increased length, surface, tips both genotypes, but a greater extent occurred 'IR8192'. Under Zn deficient conditions, many swollen mitochondria observed the tip...
Metastasis-associated protein 1 (MTA1), a negative epigenetic modifier, plays critical role in prostate cancer (PCa) progression. We hypothesized that MTA1 overexpression primary tumor tissues can predict PCa aggressiveness and metastasis. Immunohistochemical staining of was done on archival specimens from University Mississippi Medical Center Iowa. found nuclear positively correlated with the severity disease progression reaching its highest levels metastatic PCa. Nuclear significantly...
Restorative/protective therapies to restore dopamine neurons in the substantia nigra pars compacta (SNpc) are greatly needed effectively change debilitating course of Parkinson's disease. In this study, we tested therapeutic potential a neurogenic neurosteroid, allopregnanolone, restoration components nigrostriatal pathway MPTP-lesioned mice by measuring striatal levels, total and tyrosine hydroxylase immunoreactive neuron numbers BrdU-positive cells SNpc. An acute treatment (once/week for...
Acute alveolar hemorrhage in systemic lupus erythematosus usually occurs as a pulmonary-renal syndrome. In most cases, the lungs show "bland" with little or no inflammation. Whether this injury is similar to better-defined noninflammatory renal vasculopathy unresolved.To investigate relationships and mechanisms of small vascular lung kidney 2 patients who died diffuse AH.We investigated relationship AH immune complex deposition 6 correlated findings glomerular disease kidney. Lung were...
Abstract Context.—Acute alveolar hemorrhage in systemic lupus erythematosus usually occurs as a pulmonary-renal syndrome. In most cases, the lungs show “bland” with little or no inflammation. Whether this injury is similar to better-defined noninflammatory renal vasculopathy unresolved. Objectives.—To investigate relationships and mechanisms of small vascular lung kidney 2 patients who died diffuse AH. Methods.—We investigated relationship AH immune complex deposition 6 correlated findings...
Bortezomib (BTZ) serves as a first-line medication for multiple myeloma (MM) therapy. Unfortunately, despite its prominent efficacy in MM therapy, BTZ-induced peripheral neuropathy (BIPN) presents significant challenge patients lacks an established therapeutic solution. Previous research has demonstrated the involvement of lysosomal dysfunction Schwann cells key pathological process BIPN, suggesting that agents enhancing activity could hold promise treatment BIPN. Gallic acid (GA) is natural...
Wet-chemical method for extracting phosphorus (P) from sludge incineration ash suffers great P loss in the and P-leaching stages due to multidirectional migration of diversified species. Existing single-process optimizations are difficult meet diverse often conflicting needs two upstream downstream processes recover different Herein, we developed a system-oriented strategy, HyperPhosⓅ, synergistically address multiprocess requirements. It employs specially designed one-pot pretreatment...
To study the effect of inhibition hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) on spatial memory with cerebral ischemia-reperfusion (IR) in rats, middle artery occlusion was performed to induce IR injury. ZD7288 (5 µg/µl) and MK-801 (100 were administrated by lateral ventricular injection. Except for sham group, all other groups subjected ischemia 2 h followed reperfusion 4 weeks. The neurological impairment evaluated using deficit score, Morris water maze...
♦ Background We hypothesized that both sterile solutions and foreign body reaction to the peritoneal dialysis catheter are associated with inflammatory changes in rats exposed hypertonic solution. Methods Four (30 – 40 mL) were injected daily via needle syringe over 20 weeks 4 groups of rats: 4.25% standard clinical solution (LAC), LAC plus pyridoxamine (PYR), ethyl pyruvate (EP), a biocompatible 4% dextrose (BIC). Two received catheters: non-injected 4-week group (C4) for BIC (CI). Control...