A5076776059- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Multiple and Secondary Primary Cancers
- Genetic factors in colorectal cancer
- Neuroendocrine Tumor Research Advances
- PI3K/AKT/mTOR signaling in cancer
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Colorectal and Anal Carcinomas
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Animal Disease Management and Epidemiology
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Lung Cancer Treatments and Mutations
- Ultrasound Imaging and Elastography
- Enzyme function and inhibition
- Cancer Mechanisms and Therapy
- Glutathione Transferases and Polymorphisms
Sir Run Run Shaw Hospital
2012-2025
Zhejiang University
2012-2025
Hubei Provincial Center for Disease Control and Prevention
2024
Second Affiliated Hospital of Zhejiang University
2024
Guangdong Provincial Center for Disease Control and Prevention
2012-2023
University of North Carolina at Chapel Hill
2021
Lung Institute
2021
University of Missouri Health System
2021
University of Missouri
2021
Peking University First Hospital
2021
Abstract Peritoneal metastasis (PM) is considered one of the most dreaded forms cancer metastases for both patients and physicians. Aggressive cytoreductive surgery (CRS) primary treatment peritoneal metastasis. Unfortunately, this intensive frequently causes clinical complications, such as postoperative recurrence, metastasis, adhesion formation. Emerging evidence suggests that neutrophil extracellular traps (NETs) released by inflammatory neutrophils contribute to these complications....
Abstract Pyogenic liver abscess (PLA) is a common intra-abdominal infection in adults. In this study, we aim to explore demographic and clinical characteristics of PLA focusing on Klebsiella pneumoniae (K. ) induced (KP-PLA) mainland China. A retrospective review medical records from all patients with KP-PLA admitted tertiary teaching hospital over 21-year period (1994–2015) was performed. Among 296 cases confirmed culture-positive data, K. revealed as the predominant pathogen ( n = 189,...
Marital status is viewed as an independent prognostic factor for survival in various cancer types. However, its role primary liver has yet to be thoroughly explored.To investigate the impact of marital on outcomes among patients.We finally identified 40,809 eligible patients between 2004 and 2012, including 21,939 (53.8%) were married at diagnosis 18,870 (46.2%) unmarried (including 5,871 divorced/separated, 4,338 widowed 8,660 single). Married enjoyed overall cause-specific compared with...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used but often cause small intestinal ulcers (SIUs), for which effective therapies lacking. Sishen Pill (SSP), a traditional Chinese medicine, shows therapeutic promise, yet its mechanisms remain unclear. This study integrates network pharmacology, molecular docking, and experimental validation to systematically investigate SSP's protective against NSAID-induced SIUs. Active SSP ingredients were screened using the Traditional Medicine...
AIM:To investigate the pattern of symptoms, predominant bowel habits and quality life (QOL) by Chinese version SF-36 in irritable syndrome (IBS) consulters Zhejiang province.METHODS: From January 2001 to 2002, 662 Roma II criteria-positive IBS patients were enrolled gastroenterologists 10 hospitals from Digestive Disease Center (DDCZ).Patients classified into constipation (IBS-C), diarrhea (IBS-D) alternating (IBS-A) according habits.All evaluated for demographic checklists, extra-colonic...
// Xing-Kang He 1, 2, * , Yue Ding and Lei-Min Sun 2 1 Department of Gastroenterology, Sir Run Shaw Hospital, Zhejiang University Medical School, Hangzhou 310016, China Institute University, These authors contributed equally to this work Correspondence to: Sun, email: sunleimin@yahoo.com Keywords: contrast-enhanced EUS, doppler harmonic pancreatic adenocarcinomas Received: July 10, 2016 Accepted: June 18, 2017 Published: 01, ABSTRACT Aim: We aim assess the diagnostic value endoscopic...
With an increasing trend of patients with young-onset colorectal cancer (CRC), risks second primary cancers (SPCs) among them become a concerning issue. We aimed to define the detailed risk and site-distributed patterns SPCs in young CRC individuals (age ≤50). A population-based cohort were identified from Surveillance, Epidemiology, End Results database between 1973 2013. Standardized incidence ratios (SIRs) absolute excess (AER) calculated assess for compared general population. total...
Though methods for the diagnosis of pancreatic masses are various, such as ultrasonography (US), computed tomography (CT), endoscopic (EUS), and contrast-enhanced (CE-CT), their sensitivity, specificity, accuracy not quite satisfying. Contrast-enhanced (CE-EUS), a new technique, has its own unique advantages in diagnosing disease. However, still controversial. To evaluate CE-EUS differential between benign malignant mass lesions. Eighteen relevant articles systemically searched from PubMed,...
During liver regeneration after partial hepatectomy, the function and metabolic pathways governing transient lipid droplet accumulation in hepatocytes remain obscure. Mammalian target of rapamycin 2 (mTORC2) facilitates de novo synthesis hepatic lipids. Under normal conditions tumorigenesis, decreased levels triglyceride (TG) fatty acids (FAs) are observed mTORC2-deficient liver. However, during regeneration, their increase absence mTORC2.Rictor liver-specific knockout control mice underwent...
Abstract Apoptosis is a dynamic process regulated by mitochondrion critical for cellular respiration and survival. Execution of apoptosis mediated multiple protein signaling events at mitochondria. Initiation progression require numerous apoptogenic factors that are either released from or sequestered in mitochondria, which may transform the biomolecular makeup organelle. In this communication, using Raman microspectroscopy, we demonstrate transformation composition be used as marker an...
Previous studies indicated cancer survivors had a higher risk of developing subsequent pancreatic ductal adenocarcinoma. However, the influence prior on survival outcomes current remains unclear.
Increased production of reactive oxygen species, which cause oxidative DNA damage, is considered to be related gastric carcinogenesis. The aim this research was detect the 8-OHdG and expression hOGG1and MnSOD, in human mucosa with chronic atrophic gastritis (CAG) carcinoma (GC) comparing normal controls (NC).The level biopsy specimens assessed immunohistochemistry. MnSOD tissues Western blot.The staining CAG GC stronger than control (p<0.01). hOGG1 expressed a lower degree when compared...
Objective: To analyze the clinical courses and outcomes of COVID-19 cases influencing factors in Guangdong province provide basis for formulation or adjustment medical care epidemic control strategy COVID-19. Methods: We collected demographic data, histories, 1 350 patients reported as 4 March 2020 via epidemiological investigation process tracking. Disease severity course characteristics severe illness were analyzed our study. Results: Among Guangdong, 72 (5.3%) 049 (77.7%) mild ordinary...
SUMMARY Contaminated water is one of the main sources norovirus (NoV) gastroenteritis outbreaks globally. Waterborne NoV are infrequently attributed to GII.4 NoV. In September 2009, a outbreak affected small school in Guangdong Province, China. Epidemiological investigations indicated that household use water, supplied by well, was probable source (relative risk 1·9). nucleic acid material concentrated well-water samples detected using real-time RT–PCR. Nucleotide sequences extracted from...
Background and Aim . Rectal indomethacin was reported to be effective for postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) prophylaxis. However, the preventive effect of average-risk patients remains unclear. Recently, some conflicting evidence addressed by recent articles. We aimed determine protective role in PEP based on latest available literature. Methods A systematic literature search conducted using PubMed, Embase, Web Science, Cochrane Library identify...
In terms of incidence and pathogenesis, right-sided colon cancer (RCC) left-sided (LCC) exhibit several differences. However, whether existing differences could reflect the different survival outcomes remains unclear. Therefore, we aimed to ascertain role location in prognosis. We identified cases from Surveillance, Epidemiology, End Results database between 1973 2012. Differences among subsites regarding clinical features metastatic patterns were compared. The Kaplan-Meier curves conducted...
The anticancer effect of MK-2206, an Akt inhibitor, has been explored in some types cancers, but its on gastric cancer is unclear. In this study, we aimed to investigate cells. Cell viability and colony formation assays showed that MK-2206 effectively inhibited the proliferation SGC-7901 MKN45 50% inhibitory concentration values after 24, 48, 72 hours' treatment were 22.92, 13.68, 8.55 μM cells 19.21, 13.10, 9.11 cells, respectively. Treatment with induced apoptosis as indicated by flow...
Alcohol, tobacco smoke and Barrett's oesophagus as a consequence of gastro-oesophageal reflux are the main risk factors in oesophageal carcinogenesis. All may induce oxidative stress. Manganese superoxide dismutase (MnSOD) is one important repair enzyme for reactive stress (ROS)-induced damage. MnSOD polymorphisms -9 position signal sequence protein lead to critical deficiency. The aim present study was investigate role patients with cancer [n = 170, 61 adenocarcinoma (AC), 109 squamous cell...