A5071197560- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Biomedical Research and Pathophysiology
- Allergic Rhinitis and Sensitization
- Ocular Infections and Treatments
- Neonatal Health and Biochemistry
- Monoclonal and Polyclonal Antibodies Research
- Retinal Diseases and Treatments
- Amino Acid Enzymes and Metabolism
- Optical Coherence Tomography Applications
- Inflammatory mediators and NSAID effects
- Ocular Disorders and Treatments
- Retinal Development and Disorders
- Angiogenesis and VEGF in Cancer
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Dermatology and Skin Diseases
- Malaria Research and Control
- Cell Adhesion Molecules Research
- Immunotoxicology and immune responses
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Advanced Glycation End Products research
Guiyang Medical University
2023-2025
Monash University
2025
Fujian Provincial Cancer Hospital
2025
Fujian Medical University
2025
Institut de la Vision
2015-2024
Inserm
2015-2024
Sorbonne Université
2015-2024
Centre National de la Recherche Scientifique
2015-2024
Centre hospitalier national d'ophtalmologie des Quinze-Vingts
2015-2024
Kunming University of Science and Technology
2024
Cholera toxin (CTX) is a potent oral adjuvant for the induction of mucosal IgA Ab responses protein Ags. We examined and allergic sensitization several strains mice to Ags, administered orally with CTX. The made strong IgG1 serum responses, but little IgG2a Ags such as hen egg lysozyme (HEL) OVA. However, when given subsequent i.p. challenge Ag alone, same had immediate hypersensitivity reactions that included respiratory distress death. Within 10 min challenge, immunized high levels plasma...
We investigated in a rabbit model, the eye distribution of topically instilled benzalkonium_(BAK) chloride commonly used preservative drops using mass spectrometry imaging. Three groups three New Zealand rabbits each were used: control one without instillation, receiving 0.01%BAK twice day for 5 months and with 0.2%BAK drop 1 month. After sacrifice, eyes embedded frozen tragacanth gum. Serial cryosections alternately deposited on glass slides histological (hematoxylin-eosin staining)...
Aotus monkeys received 4 doses of Plasmodium falciparum EBA-175 region II vaccine as plasmid DNA (Dv-Dv) or recombinant protein in adjuvant (Pv-Pv) 3 and 1 dose (Dv-Pv). After doses, antibody titers were approximately 10(4) DNA-immunized 10(6) protein-immunized monkeys. A fourth did not significantly boost responses the Dv-Dv only Pv-Pv groups, but boosted to Dv-Pv group. Four weeks after last immunization, animals challenged with P. falciparum-parasitized erythrocytes. Peak levels...
Purpose: The aim of this study was to compare, in vivo on a rat model, two different preservatives— benzalkonium chloride (BAC) and polyquaternium-1 (PQ-1)—using new experimental approaches. Methods: Thirty (30) eyes 15 male Lewis rats were used study. Rats randomly divided into five groups instilled twice day for 11 days with eye drops containing concentrations preservatives, 0.1% BAC, 0.5% PQ-1, balanced salt solution (BSS) as control. ocular surface toxicity these preservatives...
purpose. To assess the usefulness of noninvasive combined technologies used to observe ocular surface changes in toxicology studies. methods. Benzalkonium chloride (BAC) at 0.01%, 0.1%, 0.25%, and 0.5% was applied rat corneas for 11 days. The eye evaluated macroscopically from day (D)0 D52. cornea examined with slit lamp, a fluorescein test performed, confocal microscope vivo calculate corneal thickness, score epithelial endothelial defects, quantify stromal inflammation neovascularization....
<h3>Aim:</h3> To compare the conjunctival and corneal reactions of commercially available solution latanoprost (Xalatan) preservative-free (PF) tafluprost in rabbits. <h3>Methods:</h3> The rabbits received 50 μl phosphate-buffered saline (PBS), PF-tafluprost 0.0015%, 0.005% or benzalkonium chloride (BAK) 0.02%; all solutions were applied at 5 min intervals for a total 15 times. ocular surface toxicity was investigated using slit-lamp biomicroscopy examination, flow cytometry (FCM) on...
<h3>Aims</h3> <i>Demodex</i> mites are implicated in several ocular surface diseases such as blepharitis, rosacea and dry eye syndrome. eyelid infestation is classically diagnosed by analysing depilated eyelashes under the light microscope. The use of <i>in vivo</i> confocal microscopy (IVCM) could be an easy way to improve its diagnosis. ability IVCM identify was evaluated compared with classic depilation method. <h3>Methods</h3> Eight healthy subjects, 22 patients syndrome without anterior...
Using an established three-dimensional (3D) toxicological model based on reconstituted human corneal epithelium (HCE), this study investigated the tolerability of four topical intraocular-pressure-lowering agents: commercial solutions benzalkonium chloride (BAC)-containing 0.005% latanoprost, 0.004% travoprost, 0.03% bimatoprost containing 0.02%, 0.015% and BAC, respectively, preservative-free (PF) tafluprost. Solutions 0.01% 0.02% BAC alone were also evaluated for comparison.The 3D-HCEs...
Nosocomial infections are a major threat to patients in the intensive care unit (ICU). Limited data exist on epidemiology of ICU-acquired China. This retrospective study was carried out determine current status nosocomial infection China.A review ICU tertiary hospital East China between 2003 and 2007 performed. were defined according definitions Centers for Disease Control Prevention. The overall patient rate, incidence density rate infections, excess length stay, distribution sites...
High-mobility group protein box-1 (HMGB1) is a proinflammatory involved in many inflammatory diseases. However, its roles intracerebral hemorrhage (ICH) remain unknown. The purpose of this study was to examine the correlation between changes serum levels HMGB1 following acute ICH and severity stroke as well underlying mechanism. Changes 60 consecutive patients with primary hemispheric within 12 hours onset symptoms were determined. disease severity, IL-6, TNF-<mml:math...
The study used a validated acute in vivo model to compare new formulation of travoprost 0.004% ophthalmic solution (travoprost PQ), preserved with polyquaternium-1 (PQ), commercially available formulations benzalkonium-chloride (BAK)-preserved BAK) and BAK-preserved latanoprost 0.005% (latanoprost BAK). Adult male New Zealand albino rabbits (n = 36) were randomly divided into 6 groups. Phosphate-buffered saline (PBS), 0.001% PQ, 0.015% BAK, BAK or applied onto rabbit eyes as 1 drop, for 15...
Dry eye symptoms are among the leading complaints in ophthalmology. disease (DED) is associated with significant pain affecting quality of life. Cellular and molecular mechanisms underlying ocular DED not fully understood. In this study, we investigated surface patients using vivo confocal microscopy (IVCM) to quantify corneal nerve density its relation inflammation. Gene expression proinflammatory markers HLA-DR, IL-6, CXCL12, CCL2 receptors CXCR4 CCR2, as well PENK (enkephalin precursor),...
Purpose. To evaluate the relationship between corneal and conjunctival epithelium thickness ocular surface clinical tests in dry eye disease (DED) patients. Patients Methods. Fifty-four patients with DED 32 control subjects were included. Each patient underwent an evaluation using index (OSDI), tear film break-up time (TBUT), staining, lipid layer analysis, Schirmer test. The central (CET), limbal (LET), bulbar (BET) acquired spectral-domain optical coherence tomography (SD-OCT). Results....
Purpose: The purpose of this study was to evaluate the efficacy new viscous cysteamine hydrochloride (CH) eye drops (vCH 0.55%) compared with standard CH 0.10% treatment. Methods: This an open-label, phase III, randomized, two-arm multicenter trial conducted at two centers in France. Cystinosis patients ≥2 years old were randomized 1:1 receive drops, four times per day for 90 days both eyes. We superiority reducing corneal cystine crystal density as assessed by vivo confocal microscopy...
In recent years, immune checkpoint inhibitors (ICI) have revolutionized the treatment landscape of renal cell carcinoma (RCC), significantly enhanced patient outcomes and expanded therapeutic options beyond traditional surgical targeted approaches. this review, we provide a comprehensive review current applications ICI in RCC therapy, elucidating their mechanisms action, clinical efficacy across both clear non-clear subtypes, safety profiles. We compare effectiveness monotherapy versus...
Further phytochemical investigation on the twigs of Trichilia connaroides led to isolation nine limonoids (1, 2, and 5-11), one 3,4-seco-homo-cycloartane (3), two steroids (4 12). The structures these obtained isolates were established by means detailed analyses their extensive spectroscopic information ECD calculations, four them elucidated as undescribed compounds (1-4). It is noted that an unprecedented 7-oxabicyclo[2.2.1]-heptane moiety in trichilitin M (1) was proposed linkage C-11 C-14...